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The Journal of Bone & Joint Surgery British Volume
Vol. 41-B, Issue 2 | Pages 384 - 387
1 May 1959
Lack CH

Plasmin, a proteolytic enzyme derived from the blood, may be activated in synovial fluid both by trauma to synovial tissue and cartilage, and by kinases produced by streptococci and staphylococci. Plasmin normally removes fibrin, but, when in excess, attacks the protein of cartilage matrix. Conversely, excess inhibitor favours the persistence of fibrin and subsequent fibrosis. The relationship of excess protease to the chondrolysis of suppurative arthritis and of excess inhibitor to pannus formation and fibrous ankylosis in tuberculous and rheumatoid arthritis are discussed.



The Journal of Bone & Joint Surgery British Volume
Vol. 37-B, Issue 1 | Pages 135 - 138
1 Feb 1955
Lack CH Shelswell JH