Aims. There is little information regarding the risk of a patient developing
Objectives. We used the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man (NJR) to investigate the risk of revision due to
Objectives.
Objectives.
Aims.
Aims. Fungal
Aims. The aim of this study was to evaluate the performance of metagenomic next-generation sequencing (mNGS) in detecting pathogens from synovial fluid of
Aims. Positive cultures are not uncommon in cases of revision total
knee and hip arthroplasty (TKA and THA) for presumed aseptic causes.
The purpose of this study was to assess the incidence of positive
intra-operative cultures in presumed aseptic revision of TKA and
THA, and to determine whether the presence of intra-operative positive cultures
results in inferior survival in such cases. Patients and Methods. A retrospective cohort study was assembled with 679 patients
undergoing revision knee (340 cases) or hip arthroplasty (339 cases)
for presumed aseptic causes. For all patients three or more separate
intra-operative cultures were obtained. Patients were diagnosed
with a previously unsuspected
Aims. In 2013, we introduced a specialized, centralized, and interdisciplinary team in our institution that applied a standardized diagnostic and treatment algorithm for the management of
Aims.
Aims. This pilot study tested the performance of a rapid assay for diagnosing
Aims. The increasing infection burden after total hip arthroplasty (THA) has seen a rise in the use of two-stage exchange arthroplasty and the use of increasingly powerful antibiotics at the time of this procedure. As a result, there has been an increase in the number of failed two-stage revisions during the past decade. The aim of this study was to clarify the outcome of repeat two-stage revision THA following a failed two-stage exchange due to recurrent
Objectives. The optimal protocol for antibiotic loading in the articulating cement spacers for the treatment of
Objectives. The optimal protocol for antibiotic loading in the articulating cement spacers for the treatment of
Aims. Biopsy of the periprosthetic tissue is an important diagnostic tool for
Aims. In the absence of an identified organism, single-stage revision is contraindicated in
Aims. This study aimed to explore whether serum combined with synovial interleukin-6 (IL-6) measurement can improve the accuracy of
Aims. The aim of this study was to evaluate the diagnostic accuracy of the synovial alpha-defensin enzyme-linked immunosorbent assay (ELISA) for the diagnosis of
Aims. Failure of irrigation and debridement (I&D) for
Aims. Preoperative diagnosis is important for revision surgery after
Aims. The aim of this study was to establish the diagnostic accuracy
of culture of joint aspirate with and without saline injection-reaspiration. Patients and Methods. This is a retrospective analysis of 580 hip and knee aspirations
in patients who were deemed to have a moderate to high risk of infection,
and who subsequently proceeded to revision arthroplasty over a period
of 12 years. It was carried out at a large quaternary referral centre
where preoperative aspiration is routine. Results. Fluid was aspirated primarily in 313 (54%) cases and after saline
injection-reaspiration of a ‘dry tap’ in 267 (46%) cases. Overall
sensitivity and specificity of the diagnostic aspirate were 84%
(78% to 89%) and 85% (81% to 88%), respectively. Sensitivity and
specificity of saline injection-reaspiration after ‘dry tap’ were
87% (79% to 92%) and 79% (72% to 84%) compared with 81% (71% to
88%) and 90% (85% to 93%) for direct aspiration. Conclusion. Preoperative joint aspiration and culture is a sensitive and
specific test for the confirmation of diagnosis in patients at a
moderate to high risk of
Aims. The aim of this study was to determine the prevalence and characteristics of C-reactive protein (CRP)-negative
Aims. Two-stage exchange arthroplasty is the most common definitive treatment for
Aims. This study aimed to evaluate calprotectin in synovial fluid for diagnosing chronic
Aims. To investigate the experience and emotional impact of
Aims.
Aims. Current treatments of
Aims. The aim of this study was to compare the results of 16S/28S rRNA sequencing with the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, and synovial fluid analysis in the diagnosis of
Aims. The aim of this study was to determine if the local delivery of vancomycin and tobramycin in primary total knee arthroplasty (TKA) can achieve intra-articular concentrations exceeding the minimum inhibitory concentration thresholds for bacteria causing acute
Aims. We studied the impact of direct anterior (DA) versus non-anterior (NA) surgical approaches on
Cut-off values with highest sensitivity and specificity
for the synovial fluid white cell and differential count will facilitate
the accurate diagnosis of infection in total knee (TKR) and total
hip replacement (THR). All patients undergoing revision TKR or THR
for suspected
Aims. The aims of this study were to characterize antibiotic choices for perioperative total knee arthroplasty (TKA) and total hip arthroplasty (THA) prophylaxis, assess antibiotic allergy testing efficacy, and determine rates of
Aims. Methicillin-resistant Staphylococcus aureus (MRSA) can cause wound infections via a ‘Trojan Horse’ mechanism, in which neutrophils engulf intestinal MRSA and travel to the wound, releasing MRSA after apoptosis. The possible role of intestinal MRSA in
Aims. Preoperative nasal Staphylococcus aureus screening and eradication reduces surgical site infections (SSIs) but its impact on reducing early
Aims. To establish the utility of adding the laboratory-based synovial alpha-defensin immunoassay to the traditional diagnostic work-up of a
Aims. The aim of this study was to determine if a three-month course of microorganism-directed oral antibiotics reduces the rate of failure due to further infection following two-stage revision for chronic
We propose a state-of-the-art temporary spacer, consisting of a cobalt-chrome (CoCr) femoral component and a gentamicin-eluting ultra-high molecular weight polyethylene (UHMWPE) tibial insert, which can provide therapeutic delivery of gentamicin, while retaining excellent mechanical properties. The proposed implant is designed to replace conventional spacers made from bone cement. Gentamicin-loaded UHMWPE was prepared using phase-separated compression moulding, and its drug elution kinetics, antibacterial, mechanical, and wear properties were compared with those of conventional gentamicin-loaded bone cement.Aims
Methods
Aims. The aim of this study was to assess the effects of transferring patients to a specialized arthroplasty centre between the first and second stages (interstage) of
Aims. The aims of this study were to report the efficacy of revision surgery for patients with co-infective bacterial and fungal
Aims.
Cite this article:
Aims. Leucocyte esterase (LE) has been shown to be an accurate marker of
The aim of this review was to evaluate the available literature
and to calculate the pooled sensitivity and specificity for the
different alpha-defensin test systems that may be used to diagnose
prosthetic joint infection (PJI). Studies using alpha-defensin or Synovasure (Zimmer Biomet, Warsaw,
Indiana) to diagnose PJI were identified from systematic searches
of electronic databases. The quality of the studies was evaluated
using the Quality Assessment of Studies of Diagnostic Accuracy (QUADAS)
tool. Meta-analysis was completed using a bivariate model.Aims
Materials and Methods
Aims. Recurrent infection following two-stage revision total hip arthroplasty
(THA) for
Aims. The purpose of this current multicentre study is to analyse the
presence of alpha-defensin proteins in synovial fluid using the
Synovasure lateral flow device and to determine its diagnostic reliability
and accuracy compared with the