1 . Criticisms are expressed of previous reports on the use of intra-articular injections in the treatment of osteoarthritis of the knee.

2. A series of 181 patients with primary osteoarthritis of the knee treated by certain intra-articular injections is reported. Three solutions in common use were studied; normal saline and mock injections served as controls.

3. Irrespective of the injection used, including the controls, no significant difference in the effects was demonstrated in the results.

4. The place of intra-articular injection therapy in osteoarthritis is discussed. Attention is drawn to the psychological implications.