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Bone & Joint Research
Vol. 10, Issue 9 | Pages 619 - 628
27 Sep 2021
Maestro-Paramio L García-Rey E Bensiamar F Saldaña L

Aims

To investigate whether idiopathic osteonecrosis of the femoral head (ONFH) is related to impaired osteoblast activities.

Methods

We cultured osteoblasts isolated from trabecular bone explants taken from the femoral head and the intertrochanteric region of patients with idiopathic ONFH, or from the intertrochanteric region of patients with osteoarthritis (OA), and compared their viability, mineralization capacity, and secretion of paracrine factors.


The Bone & Joint Journal
Vol. 103-B, Issue 4 | Pages 769 - 774
1 Apr 2021
Hoogervorst LA Hart MJ Simpson PM Kimmel LA Oppy A Edwards ER Gabbe BJ

Aims

Complex fractures of the femur and tibia with associated severe soft tissue injury are often devastating for the individual. The aim of this study was to describe the two-year patient-reported outcomes of patients in a civilian population who sustained a complex fracture of the femur or tibia with a Mangled Extremity Severity Score (MESS) of ≥ 7, whereby the score ranges from 2 (lowest severity) to 11 (highest severity).

Methods

Patients aged ≥ 16 years with a fractured femur or tibia and a MESS of ≥ 7 were extracted from the Victorian Orthopaedic Trauma Outcomes Registry (January 2007 to December 2018). Cases were grouped into surgical amputation or limb salvage. Descriptive analysis were used to examine return to work rates, three-level EuroQol five-dimension questionnaire (EQ-5D-3L), and Glasgow Outcome Scale-Extended (GOS-E) outcomes at 12 and 24 months post-injury.


Bone & Joint Research
Vol. 10, Issue 8 | Pages 467 - 473
2 Aug 2021
Rodríguez-Collell JR Mifsut D Ruiz-Sauri A Rodríguez-Pino L González-Soler EM Valverde-Navarro AA

Aims

The main objective of this study is to analyze the penetration of bone cement in four different full cementation techniques of the tibial tray.

Methods

In order to determine the best tibial tray cementation technique, we applied cement to 40 cryopreserved donor tibiae by four different techniques: 1) double-layer cementation of the tibial component and tibial bone with bone restrictor; 2) metallic cementation of the tibial component without bone restrictor; 3) bone cementation of the tibia with bone restrictor; and 4) superficial bone cementation of the tibia and metallic keel cementation of the tibial component without bone restrictor. We performed CT exams of all 40 subjects, and measured cement layer thickness at both levels of the resected surface of the epiphysis and the endomedular metaphyseal level.


The Journal of Bone & Joint Surgery British Volume
Vol. 50-B, Issue 3 | Pages 588 - 594
1 Aug 1968
Bentley G Jeffreys TE

1. Three cases of traumatic anuria following muscle ischaemia ("crush syndrome") are reported. 2. The pathogenesis and treatment of the condition are discussed. 3. A scheme of management directed to the prevention of renal failure is proposed


The Journal of Bone & Joint Surgery British Volume
Vol. 38-B, Issue 2 | Pages 528 - 531
1 May 1956
Henson GF

1. Two cases of arterial damage complicating shoulder injuries are reported. 2. The treatment is described and the importance of early diagnosis is stressed. 3. Operation was indicated in both cases by developing ischaemia in spite of conservative measures


The Journal of Bone & Joint Surgery British Volume
Vol. 71-B, Issue 4 | Pages 597 - 598
1 Aug 1989
Au K

Forty-five Chinese patients had below-knee amputation by a sagittal flap technique; 84% for ischaemia. Satisfactory healing was obtained in over 90%, but complications and failure were more common in patients with diabetes mellitus. A modified sagittal flap is recommended


The Journal of Bone & Joint Surgery British Volume
Vol. 47-B, Issue 2 | Pages 280 - 282
1 May 1965
Botting TDJ Scrase WH

1. Three cases of premature epiphysial closure at the knee complicating prolonged immobilisation for congenital dislocation of the hip are described. 2. The etiology of this complication is briefly discussed, and it is suggested that relative ischaemia of the epiphysial plates is the most likely cause


The Journal of Bone & Joint Surgery British Volume
Vol. 38-B, Issue 2 | Pages 513 - 517
1 May 1956
Mayor GE

1. A case of persistent exercise ischaemia affecting the anterior tibial group of muscles is described. 2. Pathogenesis and treatment are discussed. Decompression of the anterior tibial compartment is required if the patient is unwilling to give up whatever activity causes the exercise pain


The Journal of Bone & Joint Surgery British Volume
Vol. 40-B, Issue 2 | Pages 274 - 281
1 May 1958
Girgis FG Pritchard JJ

Cartilage formation was provoked in the skull vault of the young rat by making multiple incisions, and scraping the periosteum to reduce the blood supply to the injured area. The hypothesis that ischaemia induces osteogenic cells to produce cartilage in the course of fracture repair thus receives experimental support


The Journal of Bone & Joint Surgery British Volume
Vol. 67-B, Issue 4 | Pages 564 - 566
1 Aug 1985
Howie C Smith G Christie J Gregg P

Torsion and subsequent ischaemia is a well-recognised cause of symptoms and morbidity in general surgery. We present three cases of solitary pigmented villonodular tumours of the knee which were found to have undergone torsion. We believe these to be the first intra-articular tumours in which torsion has been reported


The Journal of Bone & Joint Surgery British Volume
Vol. 45-B, Issue 2 | Pages 346 - 350
1 May 1963
Maudsley RH Hopkinson WI Williams KG

1. A small mobile oxygen chamber is described which overcomes some of the disadvantages of using high pressure oxygen therapy in cases of general or local anoxia. 2. A case of limb ischaemia following an open fracture of the tibia and fibula is described in which such a method of treatment was used


The Journal of Bone & Joint Surgery British Volume
Vol. 74-B, Issue 2 | Pages 272 - 274
1 Mar 1992
Churchill M Brookes M Spencer J

We perfused 16 human femora with a 50% barium sulphate suspension and studied the intra-osseous vessels by microfocal radiography and histology. There were few anastomoses between the vessels of the greater trochanter and those of the adjacent cancellous bone of the shaft. Ischaemia of the trochanter may contribute to nonunion after trochanteric osteotomy


The Journal of Bone & Joint Surgery British Volume
Vol. 34-B, Issue 2 | Pages 245 - 247
1 May 1952
Nisbet NW

1. A case of Volkmann's ischaemic contracture, in which function was greatly improved by a muscle slide operation, is described. 2. The possibility of regeneration of muscle after ischaemia is reviewed in the light of recent research. 3. Injection experiments suggest that the forearm flexors, like the gastroenemius,are supplied by end arteries


The Bone & Joint Journal
Vol. 103-B, Issue 8 | Pages 1392 - 1399
2 Aug 2021
Kang TW Park SY Oh H Lee SH Park JH Suh SW

Aims

Open discectomy (OD) is the standard operation for lumbar disc herniation (LDH). Percutaneous endoscopic lumbar discectomy (PELD), however, has shown similar outcomes to OD and there is increasing interest in this procedure. However despite improved surgical techniques and instrumentation, reoperation and infection rates continue and are reported to be between 6% and 24% and 0.7% and 16%, respectively. The objective of this study was to compare the rate of reoperation and infection within six months of patients being treated for LDH either by OD or PELD.

Methods

In this retrospective, nationwide cohort study, the Korean National Health Insurance database from 1 January 2007 to 31 December 2018 was reviewed. Data were extracted for patients who underwent OD or PELD for LDH without a history of having undergone either procedure during the preceding year. Individual patients were followed for six months through their encrypted unique resident registration number. The primary endpoints were rates of reoperation and infection during the follow-up period. Other risk factors for reoperation and infection were also evalulated.


The Journal of Bone & Joint Surgery British Volume
Vol. 56-B, Issue 4 | Pages 712 - 715
1 Nov 1974
Puranen J

1. Exercise ischaemia in athletes with chronic pain over the postero-medial border of the tibia is described. 2. Fasciotomy of the compartment of the deep flexor muscles as a treatment of "shin splints" is recommended. 3. In eleven patients the symptoms were completely relieved and the athletes were able to start effective training within four weeks


Bone & Joint Research
Vol. 9, Issue 6 | Pages 268 - 271
1 Jun 2020
Buchalter DB Kirby DJ Egol KA Leucht P Konda SR


Bone & Joint Research
Vol. 10, Issue 7 | Pages 401 - 410
13 Jul 2021
Liu Z Wang H Wang S Gao J Niu L

Aims

Poly (ADP-ribose) polymerase (PARP) inhibitor has been reported to attenuate inflammatory response in rat models of inflammation. This study was designed to investigate the effect of PARP signalling in osteoarthritis (OA) cartilage inflammatory response in an OA rat model.

Methods

The OA model was established by anterior cruciate ligament transection with medial meniscectomy in Wistar rats. The poly (ADP-ribose) polymerase 1 (PARP-1) shRNA (short hairpin (sh)-PARP-1) and negative control shRNA (sh-NC) were delivered using a lentiviral vector and were intra-articularly injected into rats after surgery. The weight-bearing distribution of the hind limbs and the knee joint width were measured every two weeks. The expression levels of PARP-1, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) in cartilage were determined using real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) and Western blot. The serum concentrations of inflammatory cytokines were detected using enzyme-linked immunosorbent assay (ELISA).


The Journal of Bone & Joint Surgery British Volume
Vol. 81-B, Issue 4 | Pages 617 - 620
1 Jul 1999
Robinson KP

Disarticulation has been carried out in ten ankles in nine patients in whom it was not possible to use a heel flap. Four patients were able to walk with a prosthesis which gave satisfactory function. In five who were bedridden, healing was achieved and was of sufficient quality to allow transfers. There was no operative morbidity or mortality. This technique can be used instead of a transtibial amputation if necrosis or ischaemia of the heel is a contraindication to conventional Syme’s amputation


The Bone & Joint Journal
Vol. 103-B, Issue 7 | Pages 1309 - 1316
1 Jul 2021
Garg B Bansal T Mehta N

Aims

To describe the clinical, radiological, and functional outcomes in patients with isolated congenital thoracolumbar kyphosis who were treated with three-column osteotomy by posterior-only approach.

Methods

Hospital records of 27 patients with isolated congenital thoracolumbar kyphosis undergoing surgery at a single centre were retrospectively analyzed. All patients underwent deformity correction which involved a three-column osteotomy by single-stage posterior-only approach. Radiological parameters (local kyphosis angle (KA), thoracic kyphosis (TK), lumbar lordosis (LL), pelvic tilt (PT), sacral slope (SS), C7 sagittal vertical axis (C7 SVA), T1 slope, and pelvic incidence minus lumbar lordosis (PI-LL)), functional scores, and clinical details of complications were recorded.


The Journal of Bone & Joint Surgery British Volume
Vol. 72-B, Issue 1 | Pages 116 - 120
1 Jan 1990
Howard P Makin G

We report the management and outcome of 35 lower limb fractures with associated severe vascular injuries treated over a 15-year period. Limb survival was related to the period of ischaemia. Management of the fractures by immediate open reduction and internal fixation was associated with a higher amputation rate than either external fixation or simple splintage, particularly for upper tibial injuries. External fixation is recommended as the method of choice for the stabilisation of the skeletal injury. A selective policy is advised for fasciotomy