The aims of this study were to report the efficacy of revision surgery for patients with co-infective bacterial and fungal prosthetic joint infections (PJIs) presenting to a single institution, and to identify prognostic factors that would guide management. A total of 1189 patients with a PJI were managed in our bone infection service between 2006 and 2015; 22 (1.85%) with co-infective bacterial and fungal PJI were included in the study. There were nine women and 13 men, with a mean age at the time of diagnosis of 64.5 years (47 to 83). Their mean BMI was 30.9 kg/m2 (24 to 42). We retrospectively reviewed the outcomes of these PJIs, after eight total hip arthroplasties and 14 total knee arthroplasties. The mean clinical follow-up was 4.1 years (1.4 to 8.8).Aims
Patients and Methods
We studied the sensitivity and specificity of magnetic resonance arthrography (MRa) for the diagnosis of lesions of the acetabular labrum in 20 cadaver hips. The MRa results were compared with macroscopic and
Three members of a family with a symmetrical distribution of multiple metaphysial lesions presented during childhood with pathological fractures and showed a tendency to spontaneous resolution after maturity. The
1 . A case of plantar Dupuytren's disease in a woman aged twenty-three is described. 2. A review of the literature has shown that the
1 . The bone changes in von Recklinghausen's disease of the nervous system are reviewed and the gross deformities that are sometimes encountered in the cervical region are illustrated. 2. A case is described in which, at necropsy,
Failure of healing is a well-known problem after repair of the rotator cuff. This study aimed to investigate if early repair of trauma-related full-thickness rotator cuff tears (FTRCTs) could prevent this failure. In this prospective trial, 62 consecutive patients (14 women (23%), 48 men (77%); median age 61 years (interquartile range (IQR) 54 to 65)) with trauma-related FTRCT underwent arthroscopic single-row repair within six weeks of trauma. Tendon integrity was assessed one year after surgery using the Sugaya score on MR images. Patients were followed up with Western Ontario Rotator Cuff (WORC) index, EuroQol visual analogue scale (EQ VAS), and the Constant–Murley score (CS) two years after repair.Aims
Patients and Methods
1. A case of glomus tumour of the subcutaneous tissues of the knee which presented with extreme pain is described. Successful removal of the tumour led to complete relief of pain and return to normal function. 2. The
An unusual bone tumour complicating Paget's disease of the mandible is described. At the time of local excision the
1. Five cases of pseudomalignant osseous tumour of soft tissue are reported. 2. Clinical and
1. Three cases are described in which ischaemic necrosis of certain leg muscles followed exercise. 2. Previous reports of this condition are analysed, and the
Large bone defects remain a tremendous clinical challenge. There is growing evidence in support of treatment strategies that direct defect repair through an endochondral route, involving a cartilage intermediate. While culture-expanded stem/progenitor cells are being evaluated for this purpose, these cells would compete with endogenous repair cells for limited oxygen and nutrients within ischaemic defects. Alternatively, it may be possible to employ extracellular vesicles (EVs) secreted by culture-expanded cells for overcoming key bottlenecks to endochondral repair, such as defect vascularization, chondrogenesis, and osseous remodelling. While mesenchymal stromal/stem cells are a promising source of therapeutic EVs, other donor cells should also be considered. The efficacy of an EV-based therapeutic will likely depend on the design of companion scaffolds for controlled delivery to specific target cells. Ultimately, the knowledge gained from studies of EVs could one day inform the long-term development of synthetic, engineered nanovesicles. In the meantime, EVs harnessed from
Two cases of coccydynia are presented. Their definitive treatment was excision of the coccyx and the pericoccygeal tissues. The
We perfused 16 human femora with a 50% barium sulphate suspension and studied the intra-osseous vessels by microfocal radiography and
The aim of this study was to investigate the effect of hyperglycaemia on oxidative stress markers and inflammatory and matrix gene expression within tendons of normal and diabetic rats and to give insights into the processes involved in tendinopathy. Using tenocytes from normal Sprague-Dawley rats, cultured both in control and high glucose conditions, reactive oxygen species (ROS) production, cell proliferation, messenger RNA (mRNA) expression of NADPH oxidase (NOX) 1 and 4, interleukin-6 (IL-6), matrix metalloproteinase (MMP)-2, tissue inhibitors of matrix metalloproteinase (TIMP)-1 and -2 and type I and III collagens were determined after 48 and 72 hours Objectives
Methods
A case of Dupuytren's contracture is described, in which, both clinically and
A case of eosinophilic granuloma of bone in a man of thirty-three, involving the tenth and eleventh thoracic vertebrae, is described. The presenting symptom was pain and he had spinal compression with spastic paraparesis. Improvement followed operation. The operative findings and the
1. A case of polyarteritis nodosa is reported, the presenting manifestation of which was subperiosteal new bone formation in both legs. 2. The effect of cortisone on the symptoms is recorded. 3. The
Aims
Patients and Methods
1. Exostosis bursata in a patient with hereditary multiple exostoses is described. 2. Fracture of the tip of the exostosis had occurred causing acute pain and haemorrhage into the bursa. 3. Although it appeared that it might be a pseudo-joint cavity the
In addition to its orthopaedic interest, this case illustrates the special behaviour of fine particles of a synthetic material when implanted in the human body. These results may interest those engaged in the control of dusts in the plastics industry, for the inhalation of such dusts may well result in "implantation" of the material in the lung, with consequent
