The incidence of acute and chronic conditions
of the tendo Achillis appear to be increasing. Causation is multifactorial
but the role of inherited genetic elements and the influence of
environmental factors altering gene expression are increasingly
being recognised. Certain individuals’ tendons carry specific variations
of genetic sequence that may make them more susceptible to injury.
Alterations in the structure or relative amounts of the components
of tendon and fine control of activity within the extracellular
matrix affect the response of the tendon to loading with failure
in certain cases. This review summarises present knowledge of the influence of
genetic patterns on the pathology of the tendo Achillis, with a
focus on the possible biological mechanisms by which genetic factors
are involved in the aetiology of tendon pathology. Finally, we assess
potential future developments with both the opportunities and risks
that they may carry. Cite this article:
Multicentre clinical trials in trauma care are gaining prominence as a means of generating good-quality evidence to inform and influence clinical practice. We believe multicentre trials have an important role to play in supporting evidence-based practice, and further investment in such trials is justified.
The most common injury in rugby resulting in
spinal cord injury (SCI) is cervical facet dislocation. We report
on the outcome of a series of 57 patients with acute SCI and facet
dislocation sustained when playing rugby and treated by reduction
between 1988 and 2000 in Conradie Hospital, Cape Town. A total of
32 patients were completely paralysed at the time of reduction.
Of these 32, eight were reduced within four hours of injury and
five of them made a full recovery. Of the remaining 24 who were
reduced after four hours of injury, none made a full recovery and only
one made a partial recovery that was useful. Our results suggest
that low-velocity trauma causing SCI, such as might occur in a rugby
accident, presents an opportunity for secondary prevention of permanent
SCI. In these cases the permanent damage appears to result from
secondary injury, rather than primary mechanical spinal cord damage.
In common with other central nervous system injuries where ischaemia
determines the outcome, the time from injury to reduction, and hence
reperfusion, is probably important. In order to prevent permanent neurological damage after rugby
injuries, cervical facet dislocations should probably be reduced
within four hours of injury.
