Aims

The aim of this study was to evaluate the efficacy of the surgical dislocation approach and modified trapdoor procedure for the treatment of chondroblastoma of the femoral head.

Aims

Osteoarthritis (OA) is a disabling joint disorder and mechanical loading is an important pathogenesis. This study aims to investigate the benefits of less mechanical loading created by intermittent tail suspension for knee OA.

Aims

The treatment of tibial aplasia is controversial. Amputation represents the gold standard with good functional results, but is frequently refused by the families. In these patients, treatment with reconstructive limb salvage can be considered. Due to the complexity of the deformity, this remains challenging and should be staged. The present study evaluated the role of femoro-pedal distraction using a circular external fixator in reconstructive treatment of tibial aplasia. The purpose of femoro-pedal distraction is to realign the limb and achieve soft tissue lengthening to allow subsequent reconstructive surgery.

Aims

Parathyroid hormone (PTH) (1-34) exhibits potential in preventing degeneration in both cartilage and subchondral bone in osteoarthritis (OA) development. We assessed the effects of PTH (1-34) at different concentrations on bone and cartilage metabolism in a collagenase-induced mouse model of OA and examined whether PTH (1-34) affects the JAK2/STAT3 signalling pathway in this process.

1. Autografts, isografts and homografts of fibrocartilaginous callus were observed in the anterior chamber of the eye in rats. Proliferation of cartilage ceased, endochondral ossification followed, and the end-product was a new and complete ossicle with a cortex and a marrow cavity. The size and shape of the ossicle was determined by the size and shape of the sample of callus. Thus the callus in the eye performed the function of a cartilage model like that of the developing epiphysis or a healing fracture of a long bone. 2. Fibrocartilaginous callus, heavily labelled with . 3. H-thymidine, was transplanted to the eye twenty-four hours after the last injection, when there was little if any radioactive thymidine circulating in the blood. A few small chondrocytes with labelled nuclei persisted in the cores of new bone trabeculae, but the largest part of the labelled callus was resorbed and replaced by unlabelled new bone. 3. Homografts of labelled callus produced the same results as autografts at twenty-five days, but between twenty-five and forty-five days the donor cells were destroyed by the immune response of the host. 4. Isogenous transplants in host rats treated with . 3. H-thymidine between nine and thirteen days, when the callus was invaded by new blood vessels, produced many osteogenetic cells with labelled nuclei and made it possible to trace the origin of the new bone. The label appeared in the progenitor cells within twenty-four hours. While remaining thereafter in progenitor cells, it appeared also in osteoclasts (or chondroclasts) and osteoblasts in forty-eight to seventy-two hours, and in osteocytes in ninety-six to 120 hours. Chondrocytes did not proliferate and were not labelled in the eye. 5. Homogenous transplants in host rats treated with . 3. H-thymidine between five and one days before the operation also produced new bone, but contained no labelled osteoprogenitor or bone cells after twenty-five days in the eye. At forty-five days the donor tissue had been destroyed by the immune response of the host. 6. Devitalised callus was encapsulated in inflammatory connective tissue and scar. When the dead callus was absorbed by the capillaries of the host new bone formation by induction produced a scanty deposit as a delayed event in a few instances. 7. Irrespective of whether it originated in the donor or the host, a connective-tissue cell type that proliferated rapidly and became labelled with . 3. H-thymidine was identified as a progenitor cell. Differentiation and specialisation as osteoprogenitor cells occurred after the growth of blood vessels into the interior of the callus, and developed inside of excavation chambers in cartilage. Except that the interaction of the donor tissue and host cells leading to new bone formation by induction takes place in the interior of the excavation chamber, the biophysico-chemical mechanism is unknown

Aims

Though the pathogenesis of Legg-Calve-Perthes disease (LCPD) is unknown, repetitive microtrauma resulting in deformity has been postulated. The purpose of this study is to trial a novel upright MRI scanner, to determine whether any deformation occurs in femoral heads affected by LCPD with weightbearing.

Aims

We aimed to evaluate the health-related quality of life (HRQoL) in children with supracondylar humeral fractures (SCHFs), who were treated following the recommendations of the Paediatric Comprehensive AO Classification, and to assess if HRQoL was associated with AO fracture classification, or fixation with a lateral external fixator compared with closed reduction and percutaneous pinning (CRPP).

Aims

The aim of this study was to clarify the factors that predict the development of avascular necrosis (AVN) of the femoral head in children with a fracture of the femoral neck.

Aims

Preserving growth following limb-salvage surgery of the upper limb in children remains a challenge. Vascularized autografts may provide rapid biological incorporation with the potential for growth and longevity. In this study, we aimed to describe the outcomes following proximal humeral reconstruction with a vascularized fibular epiphyseal transfer in children with a primary sarcoma of bone. We also aimed to quantify the hypertrophy of the graft and the annual growth, and to determine the functional outcomes of the neoglenofibular joint.

Aims

The purpose of this study was to report the long-term results of extendable endoprostheses of the humerus in children after the resection of a bone sarcoma.

1. By questionnaire, an attempt has been made to ascertain the characteristics of a hundred cases of slipping of the upper femoral epiphysis. 2. The principal object has been to see whether an etiological classification would be possible pending an assessment of the results of treatment. 3. Proper statistical analysis has proved impossible because of the incompleteness of the data. 4. As usual, boys predominated and were usually affected as much as three years older than the girls. 5. It was exceptional to find epiphysial slipping in a girl once she had begun to menstruate. 6. Nearly a quarter of the cases were bilateral, or became so after six to twenty-four months or more. 7. Little information came from an enquiry about dietary fads, the estimation of urinary ketosteroid excretion in twenty-three of the patients, or some minor pathological investigations. 8. No convincing evidence was found of skeletal retardation or of general thickening of epiphysial discs, such as might perhaps be expected in a hormonal disturbance characterised by defective epiphysial maturation. 9. From each child with the necessary data, indices of height, weight and build were ascertained, which would indicate his expectation of finding a place among a hundred physically normal children of his own sex and age, and, if so, where that place would be. From these studies four groups of children seemed to emerge: I) what may be called abnormally heavy children who would not find a place among a hundred, or somestimes a thousand, physically "normal" children of their own age and sex; 2) unusually heavy children who would find a place in the heaviest minority of the normal hundred; 3) a very small group of abnormally small people, among whom might be expected the subjects of pituitary infantilism; and 4) a large group of children of average physique for their sex and age. 10. From this information and from clinical evidence in the case returns, it appeared that a quarter of the assessable boys and nearly two-thirds of the assessable girls showed evidence of endocrine defect, quite apart from those who were merely unusually fat. 11. By distinguishing these two groups of children from a third group of constitutionally "normal," an attempt has been made to see whether there is any correlation between evident endocrine defect and such characteristics as bilateral affection, delayed epiphysial maturation, a history of relevant injury and its nature, and sudden or gradual epiphysial slipping. 12. No relationship was established between any of these characteristics and endocrine type: bilateral affection was no commoner in the endocrine group; delayed maturation was not demonstrated in either; a history of relevant injury was equally common, and its nature identical, in both; slipping might be sudden or gradual in either indiscriminately. 13. There was a history of seemingly relevant injury in half the patients, and it was much commoner with sudden slipping than with gradual slipping. Sudden slipping was often preceded by symptoms of gradual slipping, or sudden slipping of one epiphysis was sometimes followed by gradual slipping of the other. 14. In gradual slipping the cardinal symptoms were pain and limp, usually starting synchronously and gradually; the pain was usually intermittent and referred much more often to the hip than the knee; the limp was usually continuous. 15. Of signs, demonstrable wasting seemed to be absent as often as present, but shortening was usual. Lateral rotation deformity was usually present, adduction often, and flexion sometimes. In more than a third of the cases limitation of movement was slight enough to be easily missed. 16. The radiographic observations confirmed the seeming widening at the affected epiphysial disc, the greater displacement revealed by the lateral view, and the difficulty of identifying avascular necrosis before collapse. 17. Treatment was delayed in thirty-four cases—a third of the whole; the reasons have been analysed; diagnostic failure was the cause in nineteen. 18. A few cases outside the series have been mentioned briefly because of special points of interest: slipping in gross pituitary disease—in pituitary giantism, and(at the age of thirty-three) in pituitary hypogonadism; slipping with defect of the opposite lower limb—infantile paralysis of the leg, and Legg-Calvé-Perthes disease of the hip; familial affection—slipping in two brothers. 19. The results of treatment in the present cases, supplemented by others, have been studied by Dr John Hall and related to some of the clinical features. His paper appears separately

Aims

The aims of this study were to evaluate the abductor function in moderate and severe slipped capital femoral epiphysis (SCFE), comparing the results of a corrective osteotomy at the base of the femoral neck and osteoplasty with 1) in situ epiphysiodesis for mild SCFE, 2) contralateral unaffected hips, and 3) hips from healthy individuals.

Aims

Several studies have reported the safety and efficacy of subcapital re-alignment for patients with slipped capital femoral epiphysis (SCFE) using surgical dislocation of the hip and an extended retinacular flap. Instability of the hip and dislocation as a consequence of this surgery has only recently gained attention. We discuss this problem with some illustrative cases.

Aims

Using 90% of final height as a benchmark, we sought to develop a quick, quantitative and reproducible method of estimating skeletal maturity based on topographical changes in the distal femoral physis.