Aims

Obtaining solid implant fixation is crucial in revision total knee arthroplasty (rTKA) to avoid aseptic loosening, a major reason for re-revision. This study aims to validate a novel grading system that quantifies implant fixation across three anatomical zones (epiphysis, metaphysis, diaphysis).

Aims

Therapeutic agents that prevent chondrocyte loss, extracellular matrix (ECM) degradation, and osteoarthritis (OA) progression are required. The expression level of epidermal growth factor (EGF)-like repeats and discoidin I-like domains-containing protein 3 (EDIL3) in damaged human cartilage is significantly higher than in undamaged cartilage. However, the effect of EDIL3 on cartilage is still unknown.

Aims. The Patient-Reported Outcomes Measurement Information System (PROMIS) has demonstrated faster administration, lower burden of data capture and reduced floor and ceiling effects compared to traditional Patient Reported Outcomes Measurements (PROMs). We investigated the suitability of PROMIS Mobility score in assessing physical function in the sequelae of childhood hip disease. Methods. In all, 266 adolscents (aged ≥ 12 years) and adults were identified with a prior diagnosis of childhood hip disease (either Perthes’ disease (n = 232 (87.2%)) or Slipped Capital Femoral Epiphysis (n = 34 (12.8%)) with a mean age of 27.73 years (SD 12.24). Participants completed the PROMIS Mobility Computer Adaptive Test, the Non-Arthritic Hip Score (NAHS), EuroQol five-dimension five-level questionnaire, and the Numeric Pain Rating Scale. We investigated the correlation between the PROMIS Mobility and other tools to assess use in this population and any clustering of outcome scores. Results. There was a strong correlation between the PROMIS Mobility and other established PROMs; NAHS (rs = 0.79; p < 0.001). There was notable clustering in PROMIS at the upper end of the distribution score (42.5%), with less seen in the NAHS (20.3%). However, the clustering was broadly similar between PROMIS Mobility and the comparable domains of the NAHS; function (53.6%), and activity (35.0%). Conclusion. PROMIS Mobility strongly correlated with other tools demonstrating convergent construct validity. There was clustering of physical function scores at the upper end of the distributions, which may reflect truncation of the data caused by participants having excellent outcomes. There were elements of disease not captured within PROMIS Mobility alone, and difficulties in differentiating those with the highest levels of function. Cite this article: Bone Jt Open 2021;2(12):1089–1095

Aims

Osteonecrosis (ON) can cause considerable morbidity in young people who undergo treatment for acute lymphoblastic leukaemia (ALL). The aims of this study were to determine the operations undertaken for ON in this population in the UK, along with the timing of these operations and any sequential procedures that are used in different joints. We also explored the outcomes of those patients treated by core decompression (CD), and compared this with conservative management, in both the pre- or post-collapse stages of ON.

Aims

For paediatric and adolescent patients with growth potential, preservation of the physiological joint by transepiphyseal resection (TER) of the femur confers definite advantages over arthroplasty procedures. We hypothesized that the extent of the tumour and changes in its extent after neoadjuvant chemotherapy are essential factors in the selection of this procedure, and can be assessed with MRI. The oncological and functional outcomes of the procedure were reviewed to confirm its safety and efficacy.

Aims

High-quality clinical research in children’s orthopaedic surgery has lagged behind other surgical subspecialties. This study used a consensus-based approach to identify research priorities for clinical trials in children’s orthopaedics.

Aims

Resection of the proximal humerus for the primary malignant bone tumour sometimes requires en bloc resection of the deltoid. However, there is no information in the literature which helps a surgeon decide whether to preserve the deltoid or not. The aim of this study was to determine whether retaining the deltoid at the time of resection would increase the rate of local recurrence. We also sought to identify the variables that persuade expert surgeons to choose a deltoid sparing rather than deltoid resecting procedure.

Aims

This study analysed the clinical and radiological outcome of anatomical reduction of a moderate or severe stable slipped capital femoral epiphysis (SCFE) treated by subcapital osteotomy (a modified Dunn osteotomy) through the surgical approach described by Ganz.

We undertook a retrospective comparative study of all patients with an unstable slipped capital femoral epiphysis presenting to a single centre between 1998 and 2011. There were 45 patients (46 hips; mean age 12.6 years; 9 to 14); 16 hips underwent intracapsular cuneiform osteotomy and 30 underwent pinning in situ, with varying degrees of serendipitous reduction. No patient in the osteotomy group was lost to follow-up, which was undertaken at a mean of 28 months (11 to 48); four patients in the pinning in situ group were lost to follow-up, which occurred at a mean of 30 months (10 to 50). Avascular necrosis (AVN) occurred in four hips (25%) following osteotomy and in 11 (42%) following pinning in situ. AVN was not seen in five hips for which osteotomy was undertaken > 13 days after presentation. AVN occurred in four of ten (40%) hips undergoing emergency pinning in situ, compared with four of 15 (47%) undergoing non-emergency pinning. The rate of AVN was 67% (four of six) in those undergoing pinning on the second or third day after presentation.

Pinning in situ following complete reduction led to AVN in four out of five cases (80%). In comparison, pinning in situ following incomplete reduction led to AVN in 7 of 21 cases (33%). The rate of development of AVN was significantly higher following pinning in situ with complete reduction than following intracapsular osteotomy (p = 0.048). Complete reduction was more frequent in those treated by emergency pinning and was strongly associated with AVN (p = 0.005).

Non-emergency intracapsular osteotomy may have a protective effect on the epiphyseal vasculature and should be undertaken with a delay of at least two weeks. The place of emergency pinning in situ in these patients needs to be re-evaluated, possibly in favour of an emergency open procedure or delayed intracapsular osteotomy. Non-emergency pinning in situ should be undertaken after a delay of at least five days, with the greatest risk at two and three days after presentation. Intracapsular osteotomy should be undertaken after a delay of at least 14 days. In our experience, closed epiphyseal reduction is harmful.

Cite this article: Bone Joint J 2015;97-B:412–19.

A fracture of the neck of the radius when the head is not ossified can be difficult to assess and treat. In a four-year-old child we suspected from the radiographs that there was an O’Brien type-III injury after trauma. Partial manual reduction of the non-ossified radial head was completed using the Métaizeau technique of intramedullary Kirschner (K-) wiring aided by intraoperative arthrography. The child had a full range of movement at the elbow and wrist when reviewed 11 weeks after the injury, three weeks after removal of the K-wire. We suggest that intraoperative arthrography is a useful complement to the Métaizeau technique for successful reduction of fractures of the radial neck in the presence of a non-ossified radial head.

We reviewed the long-term results of the treatment of slipped upper femoral epiphysis (SUFE) using realignment procedures in 36 patients (37 hips) at an average follow-up of 33.8 years (26 to 42). There were serious short-term complications in seven of the 22 hips treated by subcapital osteotomy, three of the 11 hips treated by intertrochanteric osteotomy and three of the four hips treated by manipulative reduction.

At re-examination, the clinical and radiological results were excellent or good in 41% of the hips treated by subcapital osteotomy, in 36% treated by intertrochanteric osteotomy and in none treated by manipulative reduction. In all, seven hips (19%) had had arthrodesis or total hip replacement.

The natural history of SUFE was probably not improved by any of the treatments used in our study. We therefore discourage the use of subcapital and intertrochanteric osteotomy as well as manipulative reduction in the primary treatment of chronic SUFE.

Several authors have reported complications from screw removal after treatment of slipped upper femoral epiphysis by single screw fixation, and have attributed these to poor screw design. We have developed a simple and reliable method of screw removal which uses a cannulated 8.0 mm end-threaded cancellous screw (Smith & Nephew Richards Medical, Memphis, Tennessee) and a specially designed cannulated trephine.

The method has been successful, with minimal complications, and a limited surgical exposure.

1. A case is reported of a girl aged fifteen with growth hormone deficiency who developed a slip of the left femoral capital epiphysis at the age of seventeen during human growth hormone therapy.

2. The epiphysiolysis is regarded as iatrogenic.

1. Attention is drawn to the danger of avascular necrosis developing in the capital femoral epiphysis as a complication of osteomyelitis in the intertrochanteric region.

2. This necrosis is commonly aseptic. It is believed to be caused by compression or thrombosis of the epiphysial vessels.

3. The situation will be aggravated if infection spreads to involve the joint.

4. We believe that prompt decompression of both the joint and the bone is indicated in order to reduce the incidence and severity of these complications.

1. The results of thirty-five acutely slipped upper femoral epiphyses, treated from 1950 to 1969, are presented. Avascular necrosis of the femoral head occurred in five cases.

2. Skin traction with medial rotation, followed in three to four days by internal fixation, without further manipulation, is recommended so that this iatrogenic complication may be avoided.

1. Six cases of necrosis of articular cartilage complicating slipping of the upper femoral epiphysis are reviewed: histological examination in one case showed death of the superficial two-thirds of the articular cartilage, with survival of a layer of basal chondrocytes. In all six cases, after severe initial reduction of joint space as seen radiographically, there was gradual return of joint space, suggesting some regeneration of articular cartilage. The prognosis after cartilage necrosis is therefore not always so bad as has been supposed.

2. Various hypotheses concerning the cause of cartilage necrosis complicating slipped epiphysis are reviewed. The precise cause remains unknown, but there is substantial evidence against its being a consequence of ischaemia of the femoral head.

This series, albeit consecutive and unselected, is very small; conclusions must therefore be tentative. The results do however suggest that the dangers of late manipulative reduction properly performed may have been exaggerated. Attempted without undue force it proved a harmless procedure, often successful even in cases of long duration. When it succeeds, the results in slips of unacceptable degree are at least as good as those following the more major surgical procedures, which can thus be avoided. Even when the displacement is minor its correction should on theoretical grounds at least decrease the prospects of later osteoarthritis. The only absolute contra-indication is a fused epiphysial plate. The degree of slip and above all the duration of symptoms should not preclude an attempt at manipulative reduction.

1. Thirteen cases of traumatic separation of the upper femoral epiphysis have been studied. Four were previously reported and nine new cases are analysed.

2. This is a rare injury occurring in young children and is due to severe violence.

3. Separation occurred at the epiphysial plate, and severe posterior displacement was frequent. The fracture line does not penetrate the epiphysis.

4. Premature fusion, avascular necrosis or non-union (individually or together) occurred in eleven of the thirteen patients.

5. Separation of the upper femoral epiphysis is a serious injury which is likely to lead to permanent deformity.

1. During the past twenty-five years there have been admitted to this orthopaedic service twelve children or adolescents having a close relative who previously or subsequently developed slipped upper femoral epiphysis. This represents an incidence of approximately 7 per cent.

2. There is some evidence that the incidence is considerably higher.

3. In addition to those with close relations also with slipped epiphysis, two patients had parents with osteoarthritis of the hip.

4. I believe, therefore, that in slipped upper femoral epiphysis there is evidence of a genetic defect. This is probably due to a recessive gene of low penetrance. The frequency in this region is high because the north-east of Scotland has very definite geographical boundaries and the rural, agricultural population, from which the majority of these cases were drawn, has formed until recently a stable community likely to show a greater than average incidence.

1 . This case of post-traumatic osteochondritis of the lower tibial epiphysis is important because the condition is rare.

2. The similarity to osteochondritis in other sites dating from a single injury is noted.

3. The ankle joint bears more body weight per surface area of articular cartilage than other weight-bearing joint surfaces. It is of interest that regeneration took place in spite of the fact that the child continued to bear weight and that the joint was immobilised for only two months, beginning four months after the original injury.

1. Five cases of greenstick fracture of the upper end of the ulna with dislocation of the radio-humeral joint are described.

2. Although the direction of angulation of the fracture and the corresponding displacement of the upper end of the radius may be lateral, medial or anterior, it is suggested that all five cases form a group in which the mechanism of injury is essentially the same. This mechanism is considered to be a fall on the outstretched hand with the forearm held in supination.

3. The complications of the injury are described.

1. Seventeen children with fracture-separations of the capitular epiphysis are reviewed.

2. Soft-tissue suture was used in eleven and metallic fixation in six children.

3. There was one bad result because of faulty technique but all the other children obtained good results.

4. Soft-tissue suture was found to be a simple procedure with none of the complications of wire fixation.

1. Avascular necrosis of the bony epiphysis or necrosis of the articular cartilage of the hip joint–without bony necrosis–can occur after a slipped upper femoral epiphysis.

2. In avascular necrosis of the bony epiphysis the prognosis depends upon the degree of revascularisation that occurs and upon survival of the articular cartilage. The articular cartilage can survive and a good functioning hip result especially if aided by mobilisation without weight bearing.

3. The prognosis after necrosis of the articular cartilage is poor. This complication occurs more often when conservative treatment is used.

4. A certain number of hips will show poor results no matter what treatment is used.

5. Nutrition of the articular cartilage is probably by the synovial fluid.

6. Strong traction may damage the soft-tissue structure of the hip joint.

7. It is not advisable to perform an osteotomy soon after a slip of the epiphysis. It is better to wait until good function is assured in the joint.

Calcified matrix that is being absorbed has a characteristic appearance. At the junction of the epiphysis and metaphysis in the rat tibia this appearance can be seen near capillary endothelium as well as under osteoclasts. It is concluded that absorption can take place under the walls of capillaries without the presence of osteoclasts.

1. The case history of a seven and a half-year-old boy who developed increased radiographic density of the femoral capital epiphysis after traumatic dislocation of the hip is presented.

2. The authors have been able to examine the case reports of thirteen similar cases presented in the literature.

3. The case presented is felt to be of interest because avascular necrosis was diagnosed early, and the radiographic appearance of the hip became normal five months after the injury.

Simple pinning to fix the epiphysis in those patients in whom the position is acceptable is a valuable surgical procedure. It is safe and gives good results. It eliminates the danger of further displacement, promotes fusion of the epiphysial plate and allows the patient to return to full activity within one month, thus avoiding joint stiffness, muscle atrophy, osteoporosis and interference with growth at other sites.

Fixation by small pins is preferable to the use of the trifin nail, the latter giving excessive trauma and predisposing to subtrochanteric fracture. Gentle replacement of the epiphysis, when loose, into an acceptable position is a valuable method of treatment. It is essential that replacement is not undertaken by force.

The problem of major displacement of the epiphysis which cannot be so replaced is unsolved. Conservative treatment in this group is useless and harmful. Intra-articular osteotomy can give good results in most cases but is risky and may cause stiffening of the hip. Subtrochanteric osteotomy does not give a good anatomical result but in most cases the function of the hip is satisfactory.

Slipping of the upper femoral epiphysis, however slight, should be regarded as a surgical emergency.

1. Epiphysial tilt commonly precedes slipping.

2. This tilt is due to a diminished or arrested growth from compression of the back of the epiphysial plate.

3. The stresses on the upper end of the femur are such that the upper femoral epiphysial plate is peculiarly liable to compression.

4. A primary abnormality of the cartilage of the epiphysial plate renders it susceptible to the effect of compression.

5. Because this abnormality is diffuse, deformities due to a similar pathology may be found elsewhere, notably in the spine.

1. A series of eighty-one hips with slipped upper femoral epiphysis in sixty-three patients is reviewed.

2. The importance of early diagnosis is emphasised.

3. Conservative treatment is condemned.

4. In attempting reduction violent manipulation and strong traction must be avoided.

5. In cases of slight displacement pinning in the position of displacement gives the best results.

6. Three or four small pins are recommended for fixation.

7. When the amount of slip is 50 per cent or more of the diameter of the head gentle manipulation should be tried and, if successful, followed by fixation with three or four pins.

8. The hip with an irreducible slip of 50 per cent or more should be treated by pertrochanteric or subtrochanteric osteotomy.

1. Two new cases of obstetrical separation of the upper femoral epiphysis are described.

2. Diagnosis in the first instance must be largely clinical, because radiological confirmation of the injury may be delayed.

3. The simple method of longitudinal traction is the treatment recommended.

4. It is notable that in our first case the ossification centre of the femoral head appeared at the exceptionally early age of fifteen days.

1. Thirteen cases of non-union of the epiphysis of the lateral condyle of the humerus were studied. Ten followed minor lateral luxations of the epiphysis; three were sequelae of open reduction and soft-tissue suture of major displacements.

2. In three cases in which non-union developed while the patient was under observation, union was secured after bone grafting by a technique described.

1. By questionnaire, an attempt has been made to ascertain the characteristics of a hundred cases of slipping of the upper femoral epiphysis.

2. The principal object has been to see whether an etiological classification would be possible pending an assessment of the results of treatment.

3. Proper statistical analysis has proved impossible because of the incompleteness of the data.

4. As usual, boys predominated and were usually affected as much as three years older than the girls.

5. It was exceptional to find epiphysial slipping in a girl once she had begun to menstruate.

6. Nearly a quarter of the cases were bilateral, or became so after six to twenty-four months or more.

7. Little information came from an enquiry about dietary fads, the estimation of urinary ketosteroid excretion in twenty-three of the patients, or some minor pathological investigations.

8. No convincing evidence was found of skeletal retardation or of general thickening of epiphysial discs, such as might perhaps be expected in a hormonal disturbance characterised by defective epiphysial maturation.

9. From each child with the necessary data, indices of height, weight and build were ascertained, which would indicate his expectation of finding a place among a hundred physically normal children of his own sex and age, and, if so, where that place would be. From these studies four groups of children seemed to emerge: I) what may be called abnormally heavy children who would not find a place among a hundred, or somestimes a thousand, physically "normal" children of their own age and sex; 2) unusually heavy children who would find a place in the heaviest minority of the normal hundred; 3) a very small group of abnormally small people, among whom might be expected the subjects of pituitary infantilism; and 4) a large group of children of average physique for their sex and age.

10. From this information and from clinical evidence in the case returns, it appeared that a quarter of the assessable boys and nearly two-thirds of the assessable girls showed evidence of endocrine defect, quite apart from those who were merely unusually fat.

11. By distinguishing these two groups of children from a third group of constitutionally "normal," an attempt has been made to see whether there is any correlation between evident endocrine defect and such characteristics as bilateral affection, delayed epiphysial maturation, a history of relevant injury and its nature, and sudden or gradual epiphysial slipping.

12. No relationship was established between any of these characteristics and endocrine type: bilateral affection was no commoner in the endocrine group; delayed maturation was not demonstrated in either; a history of relevant injury was equally common, and its nature identical, in both; slipping might be sudden or gradual in either indiscriminately.

13. There was a history of seemingly relevant injury in half the patients, and it was much commoner with sudden slipping than with gradual slipping. Sudden slipping was often preceded by symptoms of gradual slipping, or sudden slipping of one epiphysis was sometimes followed by gradual slipping of the other.

14. In gradual slipping the cardinal symptoms were pain and limp, usually starting synchronously and gradually; the pain was usually intermittent and referred much more often to the hip than the knee; the limp was usually continuous.

15. Of signs, demonstrable wasting seemed to be absent as often as present, but shortening was usual. Lateral rotation deformity was usually present, adduction often, and flexion sometimes. In more than a third of the cases limitation of movement was slight enough to be easily missed.

16. The radiographic observations confirmed the seeming widening at the affected epiphysial disc, the greater displacement revealed by the lateral view, and the difficulty of identifying avascular necrosis before collapse.

17. Treatment was delayed in thirty-four cases—a third of the whole; the reasons have been analysed; diagnostic failure was the cause in nineteen.

18. A few cases outside the series have been mentioned briefly because of special points of interest: slipping in gross pituitary disease—in pituitary giantism, and(at the age of thirty-three) in pituitary hypogonadism; slipping with defect of the opposite lower limb—infantile paralysis of the leg, and Legg-Calvé-Perthes disease of the hip; familial affection—slipping in two brothers.

19. The results of treatment in the present cases, supplemented by others, have been studied by Dr John Hall and related to some of the clinical features. His paper appears separately.

1. The mechanism of production of injury to the lateral condyle epiphysis is discussed.

2. A technique of closed reduction of rotational displacements of the epiphysis is described. Nine cases in which the method was successful are noted.

3. It is suggested that the injury should be classified with dislocation of the elbow.

Five cases of fracture-separation of the proximal epiphysis of the humerus are recorded. A method of reduction and immobilisation is described, and the literature is reviewed.

1. An apparatus was designed to determine the shearing strength of the upper tibial epiphysis in the rat. Observations were made with this instrumenton normal animals, on animals receiving growth-hormone, and on animals receiving oestrogen.

2. When the epiphysis separates from the diaphysis, the plane of cleavage is constant, passing through the third layer of the epiphysial plate.

3. Growth-hormone decreases and sex-hormone increases the shearing strength of the epiphysial plate. These changes are due to alterations produced by these two hormones in the thickness of the third layer of the epiphysial plate.

4. It is suggested that these findings may be of significance in providing an anatomical basis for slipping of the upper femoral epiphysis in man, especially when it is associated with the adiposo-genital syndrome or with rapid adolescent growth.