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Bone & Joint Research
Vol. 6, Issue 6 | Pages 366 - 375
1 Jun 2017
In vivo and clinical application of strontium-enriched biomaterials for bone regeneration
Neves N Linhares D Costa G Ribeiro CC Barbosa MA
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Objectives

This systematic review aimed to assess the in vivo and clinical effect of strontium (Sr)-enriched biomaterials in bone formation and/or remodelling.

Methods

A systematic search was performed in Pubmed, followed by a two-step selection process. We included in vivo original studies on Sr-containing biomaterials used for bone support or regeneration, comparing at least two groups that only differ in Sr addition in the experimental group.

Bone & Joint Research
Vol. 1, Issue 7 | Pages 145 - 151
1 Jul 2012
Osteoinduction by combining bone morphogenetic protein (BMP)-2 with a bioactive novel nanocomposite
Sharma A Meyer F Hyvonen M Best SM Cameron RE Rushton N
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Objectives

There is increasing application of bone morphogenetic proteins (BMPs) owing to their role in promoting fracture healing and bone fusion. However, an optimal delivery system has yet to be identified. The aims of this study were to synthesise bioactive BMP-2, combine it with a novel α-tricalcium phosphate/poly(D,L-lactide-co-glycolide) (α-TCP/PLGA) nanocomposite and study its release from the composite.

Methods

BMP-2 was synthesised using an Escherichia coli expression system and purified. In vitro bioactivity was confirmed using C2C12 cells and an alkaline phosphatase assay. The modified solution-evaporation method was used to fabricate α-TCP/PLGA nanocomposite and this was characterised using X-ray diffraction and scanning electron microscopy. Functionalisation of α-TCP/PLGA nanocomposite by adsorption of BMP-2 was performed and release of BMP-2 was characterised using an enzyme-linked immunosorbent assay (ELISA).

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