1. A twenty-five-year-old man who developed neuropathic arthritis because of indifference to pain is described. He presented at the age of thirteen with degenerative changes in the light knee with analgesia only in the right leg below the knee.

2. A painless fracture of the ulna developed non-union and was associated with a neuropathic arthritis of the elbow joint.

3. Later the other knee and the lumbo-sacral spine became affected. The analgesia became generalised with all other senses staying intact. Apart from tonic pupillary reactions and diminished corneal sensibility no other neurological signs could be found.

4. A deceased sister may also have suffered from the same condition.