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The Journal of Bone & Joint Surgery British Volume
Vol. 75-B, Issue 1 | Pages 32 - 35
1 Jan 1993
Richardson J Roberts A Robertson J John P Sweeney G

Cephamandole levels in serum and drain fluid were measured in 32 knee replacement operations to determine the benefit of an intravenous dose of antibiotic at the time of tourniquet deflation. Concentrations of cephamandole in drain fluid were directly proportional to the serum concentration at the time of tourniquet release. A 'tourniquet-release' dose of antibiotic increased drain fluid concentration threefold.