Last decade intramedullary nailing is the choice method for the treatment of lower extremity’s long bone fractures. This method matches much better the biomechanics of bones and therefore it leads to faster and better fracture porosis. The aim of our study is to record our experience of using intramedullary nailing and other methods of osteosynthesis for femur and tibia fractures and pseudarthrosis. During the last 6 years we treated 264 with long bone fractures. One hundred ninety two of them are available at least for 2 years postoperatively. Patients with major health problems or tumors were excluded. From this group of patients 116 were men and 76 women with mean age 42 years (16 up to 75). They had 107 tibial fractures, 81 femoral fractures, 12 tibial pseudarthrosis and 3 femoral pseudarthrosis. We used reamed or undreamed intramedullary nails for 64 tibial and 52 femoral fractures and we used other methods (internal fixation with plates, external fixation) for 43 tibial and 29 femoral fractures. All the cases of pseudarthrosis were after surgical treatment and they were treated only with intramedullary nails. All the nails were dynamized depending on fracture type and the healing procedure. The follow up of our patients included clinical examination (pain, length, torsion etc) and x-rays at 1st, 3rd and 6th month postoperatively and after that every year. Our data (clinical examination and x-rays) were enriched with objective estimation of patients physical condition at specific time intervals from the operation. We recorded also their one opinion about their health standard. The analysis of our results shows that intramedullary nailing, and especially after reaming, provides more rigid and secure stabilization. It also leads to faster porosis. This method allows immediate mobilization of nearby joints and better rehabilitation. It has fewer complications and we found completely valuable for the pseudrathrosis cases. Regarding only patients general health condition and return in preinjury functional level and professional activities, intramedullary nailing becomes a statistically more useful method for treatment of long bone fractures of lower extremity.