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Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 91 - 91
1 Jul 2014
Dowling R Pendegrass C Thomas B Blunn G
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Summary

Osseointegrated Amputation Prostheses can be functionalised by both biological augmentation and structural augmentation. These augmentation techniques may aid the formation of a stable skin-implant interface.

Introduction

Current clinical options are limited in restoring function to amputees, and are associated with contact dermatitis and infection at the stump-socket interface. Osseointegrated Amputation Prosthesis attempts to solve issues at the stump-socket interface by directly transferring axial load to the prosthesis, via a skin-penetrating abutment. However, development is needed to achieve a seal at the skin-implant interface to limit infection. Fibronectin, an Extracellular Matrix protein, binds to integrins during wound healing, with the RGD tripeptide being part of the recognition sequence for its integrin binding domain. In vitro work has found silanization of RGD to polished titanium discs up regulates fibroblast attachment compared to polished control. Electron Beam Melting can produce porous titanium alloy implants, which may encourage tissue attachment. This study aims to test whether a combination of biological RGD coatings and porous metal manufacturing techniques can encourage the formation of a seal at the skin-implant interface.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_4 | Pages 33 - 33
1 Jan 2013
Annetts S Coales P Colville R Mistry D Moles K Thomas B van Deursen R
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Background

Office seating includes a variety of chair styles. There is limited research investigating their effects on spinal angles.

Purpose of Study

Investigate effects of active (Swopper and Vari-Kneeler), and static (Saddle and a Standard Office) chairs on lumbo-pelvic and cervical regions.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVIII | Pages 20 - 20
1 Sep 2012
Vasarhelyi EM Thomas B Grant H Deluzio KJ Rudan JF
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Purpose

Prospective randomized intervention trial to determine whether patients undergoing rotating platform total knee arthroplasty have better clinical outcomes at two years when compared to patients receiving fixed bearing total knee arthroplasty as measured by the WOMAC, SF-36 and Knee Society (KSS) scores.

Method

67 consecutive patients (33 males and 34 females; average age 66 years) were randomized into either receiving a DePuy Sigma rotating platform (RP) total knee arthroplasty (29 patients) or a DePuy Sigma fixed bearing (FB) total knee arthroplasty (38 patients). Inclusion criteria included patients between the ages of 45–75 undergoing single-sided total knee arthoplasty for clinically significant osteoarthritic degeneration.

Pain, disability and well-being were assessed using the WOMAC, KSS, and SF-36 preoperatively and at 6 months, 1 year and 2 years post-operatively. In addition, intraoperative measures were collected. Pre-operative radiographs were analyzed using the Kellgren and Lawrence Score, modified Scotts Scoring and mechanical axis. Post-operative radiographs were collected at 1 and 2 years and analyzed to identify evidence of prosthetic loosening, implant positioning and limb alignment.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 15 - 15
1 Mar 2009
Joshy S Deshmukh S Thomas B
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Aim: Osteoarthritis of the wrist is a well recognised cause of secondary carpal tunnel syndrome. The aim of the study is to compare the outcome following carpal tunnel decompression with regard to patient satisfaction. We compared the outcome of carpal tunnel decompression between patients with and with out osteoarthritis of the wrist.

Patients and Methods: The study was done retrospectively. Clinical notes of all the patients who underwent carpal tunnel decompression over a period of 8 years were verified. Twenty four patients who underwent surgical decompression for carpal tunnel syndrome secondary to osteoarthritis were identified by reviewing the notes and the radiographs. Control group consisted of 24 patients who under went carpal tunnel decompression but without osteoarthritis of the wrist. The control group was matched for age, sex, side, and neuro-physiological severity of the nerve compression. Clinical notes were verified to find whether the patients were satisfied with the symptom relief at the first post-operative follow up visit.

Results: There were 24 patients in the group with osteoarthritis of the wrist. The mean age of the patients was 71 years (range 33–89 years). There were 19 females and five males. The right hand was involved in 17 patients and the left was involved in 7 patients. The control group with out osteoarthritis also had similar distribution regarding age sex side, and neuro-physiological severity of nerve conduction. In the group with osteoarthritis of the wrist 17(71%) patients reported the their symptom relief as satisfactory and the rest seven(29%) reported the results as unsatisfactory. In the control group 23(96%) patients reported their symptom relief as satisfactory and one (4%) reported their results as unsatisfactory (P= 0.0325).

Conclusions: Patient satisfaction following surgical decompression in patients with secondary carpal tunnel syndrome due to osteoarthritis is significantly lower compared to patients with out osteoarthritis of the wrist. Patients with osteoarthritis of the wrist should be warned about the higher incidence of poor outcome prior to decompression.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 332 - 332
1 Jul 2008
Joshy S Thomas B Gogi N Modi A Singh BK
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Infection following total knee arthroplasty is a serious complication. Recently there has been increasing incidence of isolation of multi-drug resistant bacteria from peri-prosthetic infections. The aim of our study is to identify the organisms causing delayed deep infections following primary total knee arthroplasty in the current situation. We also compared the differences in outcome based on the infecting organism. We undertook a retrospective study of all the patients who presented with delayed deep infection following primary total knee replacement during a six year period between April 1998 and March 2004. Organisms were isolated in 27 of the 31 patients who presented with delayed deep infection. Forty-four % of the organisms isolated were multi-drug resistant with increasing incidence of Methicillin resistant Staphylococcus aureus and multi-drug resistant Staphylococcus epidermidis infections. Successful outcome following an infected total knee arthroplasty was lower compared to the previous studies where there were fewer multi-drug resistant organisms. The average number of surgical procedures carried out was significantly higher when the organism isolated was multi-drug resistant. The number of patients with satisfactory outcome is significantly lower when the organism isolated is multi-drug resistant.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 329 - 329
1 Jul 2008
Joshy S Thomas B Gogi N Mahale A Singh BK
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The aim of our study is to identify the organisms causing delayed deep infections following primary total knee arthroplasty in the current situation. We also compared the differences in outcome based on the infecting organism.

We undertook a retrospective study of all the patients who presented with delayed deep infection following primary total knee replacement during a six year period between April 1998 and March 2004. We analysed the infecting organism, sensitivity of the organism to antibiotics, number of surgical procedure carried out and the outcome of the infected arthroplasty based on the infecting organism. Statistical analysis was done using Fisher’s Exact test for categorical data and Mann-Whitney U test for the non-parametric numeric data.

The mean age at the time of primary arthroplasty was 69.9 years (range 46 to 92 years, SD=10.8). The mean follow-up (time since the initial knee replacement) was 77.3 months (range 27–170 months,). The mean follow-up since the last surgical procedure to treat infection was 31 months (range 14–47 months). Organisms were isolated in 27 of the 31 patients who presented with delayed deep infection. Forty-four % of the organisms isolated were multi-drug resistant with increasing incidence of Methicillin resistant Staphylococcus aureus and multi-drug resistant Staphylococcus epidermidis infections. Successful outcome following an infected total knee arthroplasty was lower compared to the previous studies where there were fewer multi-drug resistant organisms. The number of patients with satisfactory outcome is significantly lower when the organism isolated is multi-drug resistant. Patients infected by multi-drug resistant organisms undergo higher number of surgical procedures compared to patients where the organism is not multi-drug resistant. We conclude that deep infection with MRSA and Methicillin resistant Staphylococcus epidermidis are on the rise. Outcome is significantly better when the organism isolated is non resistant Staphylococcus aureus.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 338 - 338
1 Jul 2008
Gogi N Joshy S Thomas B Mahale A Deshmukh SC
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Purpose of Study: To assess the efficacy of two-stage correction (skeletal traction followed by Partial Fasciec-tomy) in treating severe Dupuytren’s contractures.

Material, Methods and Results: We retrospectively reviewed sixteen fingers in fifteen patients with severe Dupuytren’s contracture (Tubiana Grade III/IV), operated between April 2000 and July 2005. The mean age was 58 years (27 – 82 years).

All patients underwent an initial application of Orthofix external fixator with pins in the proximal and middle phalanx. The patients were advised to gradually distract the device 3-4 times a day, for two weeks. They were then brought back for removal of fixator and partial fasciectomy with closure of skin by V-Y plasty.

The results were assessed in thirteen patients, as two were lost to follow-up. The mean follow-up period was 30 months (6 – 64 months). The total mean preopera-tive extension deficit improved from 130 degrees to 38 degrees postop.; PIP joint deformity improved from a mean of 77 degrees to 33 degrees postop. and the mean TRAM (Total range of active movements) improved from 108 degrees to 165 degrees.

Functional assessment was done using Michigan Hand Outcome Questionnaire. Overall improvement in hand function was from a preoperative 34% to a postoperative 89%.; aesthetic improvement from a preop. of 46% to a postop of 81% and pain improvement from a preop of 66% to a postop of 96%.

One patient had recurrence, one had features of RSD (Reflex Sympathetic Dystrophy) and one had to undergo amputation due to poor tolerance and persistent infection.

Conclusion: Severe Dupuytren’s contracture is a challenging deformity to deal. The two-stage correction may be considered as an alternative method of treatment in cooperative patients. Our study has shown promising results with good patient satisfaction


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 398 - 398
1 Sep 2005
Hillier T Thomas B Dale N
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Introduction Sacroiliac joint pain is resistant to diagnosis by clinical methods. CT guided diagnostic blocks are the gold standard in diagnosing SI joint pathology (Maigne J.Y. et al, Spine 1996). The current blocks have various pit falls. We have devised a new functional diagnostic block which is a modification of the currently available blocks for diagnosing sacroiliac joint pain.

Methods The patient suspected of having sacroiliac joint pain undergoes a CT-guided sacroiliac joint catheterisation. The patient is subsequently admitted to the hospital for two full days. On admission patient is charted for an injection of either a local anaesthetic or normal saline (placebo) through the catheter into the joint 2–3mls every 3–4 hourly. Only one drug is administered on any given day. On day one, the nurse in charge of the patient by the flip of a coin will decide to give one of the drugs for the day, the patient or the treating doctor not aware of the drug injected. The first injection starts at 0600hrs and the last injection at 2200 hrs. The injection details and pain score are documented on a standardised form. The patient is then taken through a range of physical activity which usually provokes the sacroiliac joint pain. The next day, the patient receives the alternate drug and undergoes the same protocol. On the third morning the patient is discharged with an appropriate follow-up. The injection given, average pain score and the level of comfort with physical activity are summarised into a form.

Discussion Our modified block has the following advantages, it is a double blinded assessment, the effect of a placebo can be tested, and it is also a functional assessment which is recorded over two days and not just a one-off response. The conclusion of the block is determined by the patient’s response and not examiner depended.


The Journal of Bone & Joint Surgery British Volume
Vol. 86-B, Issue 3 | Pages 406 - 412
1 Apr 2004
Deshmukh SC Kumar D Mathur K Thomas B

We reviewed 13 patients with a complex fracture-dislocation of the proximal interphalangeal joint of a finger and one patient with a complex fracture-dislocation of the interphalangeal joint of thumb. We had treated these injuries using a pins and rubbers traction system which had been modified to avoid friction of the pins against the bone during mobilisation of the joint in order to minimise the risk of osteolysis. A Michigan hand outcome questionnaire was used for subjective assessment. The active range of movement (AROM) of the proximal and distal interphalangeal joints and the grip strength were used for objective assessment.

The mean follow-up was 34 months (12 to 49). The mean normalised Michigan hand outcome score was 84. The mean AROM of the proximal interphalangeal joint was 85° and that of the distal interphalangeal joint 48°. The mean grip strength was 92% of the uninvolved hand.

Twelve patients have returned to their original occupations. There has been no radiological osteolysis or clinical osteomyelitis. This modified traction system has given acceptable results with a low rate of complications. It is light, cheap, effective and easy to apply.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_II | Pages 108 - 108
1 Feb 2003
Kumar D Deshmukh SC Thomas B Mathur K Breakwell L
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Ten patients, who underwent treatment for complex fracture-dislocation of the proximal interphalangeal joint of finger and one patient for that of the interphalangeal joint of thumb with a modified pins and rubbers traction system, were reviewed to evaluate the clinical and functional results. Two patients had open fracture-dislocation, 5 had pilon fractures and 4 had fracture-dislocations. The system was modified to avoid rotation of the pins in the bone during joint mobilization, thus minimizing the risk of osteolysis due to friction of pins over the bone.

Michigan hand scoring system was used for subjective assessment and range of motion at proximal and distal interphalangeal joints and grip strength for objective assessment. Average follow-up was 18 months (range 3 months to 28 months). The average normalised Michigan hand score was 86. Based on Michigan scores, overall hand function was rated excellent in 8 patients, good in 2 and poor in 1. Eight patients have returned to their original jobs. The average arc of flexion in the proximal interphalangeal joint was 85 degrees and in the distal interphalangeal joint it was 47 degrees. The average grip strength was 95 percent of the uninvolved side. Two patients developed minor pin site infection, which did not necessitate pin removal or any alteration in the treatment regime. There have been no cases of osteolysis, osteitis or osteomyelitis. This modification of pins and rubbers traction system has given very acceptable results with a low complication rate. It is light, cheap, effective and easy to apply.