Aims

Osteoarthritis (OA) is a common degenerative joint disease worldwide, which is characterized by articular cartilage lesions. With more understanding of the disease, OA is considered to be a disorder of the whole joint. However, molecular communication within and between tissues during the disease process is still unclear. In this study, we used transcriptome data to reveal crosstalk between different tissues in OA.

Objectives: Post-operative deep vein thrombosis (DVT) is considered uncommon in Japanese. Numerous reports of pulmonary embolism (PE) have been reported in the last few decades, and although thrombo-embolic diseases appear to be increasing, the incidence of DVT and PE in Japan have not been investigated thoroughly. We studied the incidence of proximal DVT and PE in Japanese patients who had total hip arthroplasty (THA) and total knee arthroplasty (TKA).

Patients and Methods: Between October 1996 and November 2000, we performed THA on 99 patients and TKA on 75 patients at Mie University Hospital. All were included in this study. They were routinely examined for proximal DVT by ultrasonography before and after their operation. Those patients who had ultrasonographic findings of DVT were also investigated for PE by ventilation-perfusion lung scan.

Results and Discussion: No patient had a DVT before surgery. Fourteen patients had post-operative DVT, detected by ultrasonography, and confirmed by venography. 12 cases were females and 2 cases were males. There were 5 cases of PE among the fourteen cases of DVT, The symptomayic PE were 2 cases, and non-incidence of PE were 3 cases. The incidence of DVT was 5.2% on the left side and 4.0% on the right side.The incidence of DVT was 11.2% in THA, and 4.0% in TKA, while that of PE was 5.0% in THA and 0% in TKA. These results suggest that DVT and PE in Japan are lower than those of white races.

Introduction: The purpose of this study was to speculate the process of degenerative changes in the lumbar spine.

Methods: The subjects were 80 (45 men and 35 women) patients aged 39–92 years (mean, 67.2 years) with degenerative change of the facet joints who had undergone surgery. These patients were divided between two groups using Gibson’s classification in T2-weighted MR images at L4-5 or L5-S1. The patients with 3 or 4 grade were regarded as D(+); otherwise as D(−). The number of patients, age, gender and the presence or absence of painful arthrosis in the limbs in each group were examined.

Results: There were 47 (20 men, 27 women) patients with a mean age of 67.5 years in the D(+) group, 33 patients (25 men, 8 women; mean age, 66.6) in the D(−) group. Painful arthrosis in the limbs was more often observed in the D(−) group than in the D(+) groups.

Conclusion: In the process of degenerative change of facet joints, some patients did not have severe disc degeneration. Most patients in the D(−) group were men and had painful arthrosis in the limbs.