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Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 44 - 44
1 Jul 2014
Ding Y Qin C Huang D Shen H
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Summary

RNAi targeting TNF-alpha inhibits particle-induced inflammation and osteolysis.

Introduction

Over 1000,000 joint prostheses are implanted every year in the world. Aseptic joint loosening is a key factor that reduces the longevity of joint prosthesis. Prosthetic wear particles are thought to play a central role in the initiation and development of periprosthetic osteolysis, leading to aseptic loosening of prostheses. This study aims to investigate the effect of RNA interference (RNAi) targeting tumor necrosis factor-alpha (TNF-α) gene on particle-induced inflammation and osteolysis in macrophages in vitro and in vivo.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 291 - 291
1 Jul 2014
Ding Y Huang J Huang D Shen H
Full Access

Summary

RNAi targeting p110β reduces TNF-alpha production and osteolysis in response to wear particles.

Introduction

Aseptic joint loosening is a key factor that reduces the life span of joint prosthesis. Prosthetic wear particles are thought to play a central role in the initiation and development of periprosthetic osteolysis, leading to aseptic loosening of prostheses. This study aims to explore the effect of p110β-targeted small interfering RNA (siRNA) and lentivirus on particle-induced inflammatory cytokine expression in murine macrophage.