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Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 179 - 179
1 Jul 2014
Carriero A Vogt M Shefelbine S
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Summary

Canals are the preferential sites for failure in cortical bone and their architecture is able to dictate the mechanical behaviour of the bone: smaller and branched canals generate a high volume of bone failure even at low apparent tissue strain.

Introduction

Osteogenesis imperfecta (OI), or brittle bone disease, is caused by mutations in the collagen genes and results in skeletal fragility. We recently showed that a mouse model of osteogenesis imperfecta (oim) has smaller and denser intracortical canals with a branched architecture compared to healthy wild type (WT) bones with similar cortical porosity [1]. We hypothesise this abnormal intracortical structure contributes to the increased fracture risk of the oim bones.