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Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 256 - 256
1 Jul 2014
Bulgakov V Gavryushenko N Shal'nev A
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Summary

Understanding of the role of the radical-generating ability of wear particles of the existing and new implant materials as well as application of efficient antioxidants is one of the necessary conditions for improvement of the results of joint replacements.

Introduction

Functioning of joint prostheses is accompanied by a continuous formation of wear particles and their accumulation in surrounding tissues. The impact of microroughnesses of joint prosthesis friction units may bring about chemical bond breakage and free-radical generation on a newly-formed wear surface. Wear particles of orthopedic alloys are capable to produce free radicals, and Co-Cr-Mo alloy particles are especially active. Free radicals generated by wear particles can cause oxidation and reduced wear resistance of polyethylene. Oxidised polyethylene particles stimulate the activity and release of bone-resorbing cytokines by human monocytes/macrophages. The ability of free radicals to cause damage to surrounding tissues and implant components makes it necessary to estimate comprehensively the radical-generating activity of wear particles of different orthopedic materials and develop the ways of its inhibition.