In total hip arthroplasty, press-fit anchorage is one of the most common fixation methods for acetabular cups and mostly ensures sufficient primary stability. Nevertheless, implants may fail due to aseptic loosening over time, especially when the surrounding bone is affected by stress-shielding. The use of acetabular cups made of isoelastic materials might help to avoid stress-shielding and osteolysis. The aim of the present numerical study was to determine whether a modular acetabular cup with a shell made of polyetheretherketone (PEEK) may be an alternative to conventional titanium shells (Ti6Al4V). For this purpose, a 3D finite element analysis was performed, in which the implantation of modular acetabular cups into an artificial bone stock using shells made of either PEEK or Ti6Al4V, was simulated with respect to stresses and deformations within the implants. The implantation of a modular cup, consisting of a shell made of PEEK or Ti6Al4V and an insert made of either ceramic or polyethylene (PE), into a bone cavity made of polyurethane foam (20 pcf), was analysed by 3D finite element simulation. A two-point clamping cavity was chosen to represent a worst-case situation in terms of shell deformation. Five materials were considered; with Ti6Al4V and ceramic being defined as linear elastic and PE and PEEK as plastic materials. The artificial bone stock was simulated as a crushable foam. Contacts were generated between the cavity and shell (μ = 0.5) and between the shell and insert (μ = 0.16). In total, the FE models consisted of 45,282 linear hexahedron elements and the implantation process was simulated in four steps: 1. Displacement driven insertion of the cup; 2. Relief of the cup; 3. Displacement driven placement of the insert; 4. Load driven insertion of the insert (maximum push-in force of 500 N). The FE model was evaluated with respect to the radial deformations of the shell and insert as well as the principal stresses in case of the ceramic inserts. The model was experimentally validated via comparison of nominal strains of the titanium shells.Introduction
Methods
Modern acetabular cups require a convenient bone stock for sufficient cup fixation. Thereby, fixation stability is influenced by the chosen interference fit of the acetabular cup, the cup surface structure, circularity of the reamed acetabulum and by the acetabular bone quality. The ideal implantation situation of the cup is commonly compromised by joint dysplasia and acetabular bone defects. The aim of the present experimental study was to characterise implant fixation of primary acetabular cups in case of definite acetabular cavity defects. For the experimental determination bone substitute blocks (100 × 100 × 50 mm) made of polymethacrylimide (PMI) foam with a density of 7 pcf were used. The created acetabular defect situations were derived from the defect classification according to Paprosky. The defect geometries in the PMI foam blocks were realised by a CNC drilling machine. Thereby the defects are described in the dorso-ventral direction by the angle α and in medio-lateral direction by the angle β (given as angle combination α/β) related to the centre of rotation of the reamed cavity. For the lever-out tests the defect types IIb and IIIa (each with different α and β angles) were considered and compared to the intact fixation situation. Therefore, a macrostructured titanium cup (Allofit, Zimmer GmbH, Wintherthur, Switzerland) with an outer diameter of 56 mm were displacement-controlled (v = 20 mm/min) pushed into the 2 mm diametric under reamed PMI-foam cavities. Three cups were inserted until the cup overhang pursuant to surgical technique was reached. Subsequently the cups were displacement-controlled (v = 20 mm/min) levered out via a rod which was screwed into the implant pole by perpendicular displacement (Uaxial) of the rod in direction of the defect aperture. The lever-out moments were calculated by multiplying the first occurring force maximum (Fmax) with the effective lever arm length (llever), whereby moments caused by the deadweight of the rod were considered. Primary stability was defined by the first maximum lever-out moment.Introduction
Materials and Methods
Nowadays, biomaterials can be used to maintain or replace several functions of the human body being constricted or lost due to tumors, fractures, injuries as well as chronic diseases, infections or simply aging. Titanium and its alloys, i.e. Ti6Al4V are the most common materials (70 to 80%) used for structural orthopedic implants due to their unique combination of good mechanical properties, corrosion resistance and biocompatibility. Addition of β-stabilizers, e. g. niobium (Nb), can improve the mechanical properties of such titanium alloys further, simultaneously offering excellent biocompatibility. Previous studies concerning biocompatibility analyses with niobium and especially Ti-42Nb specimens are rarely described; none for niobium and Ti-42Nb powders examining human cell viability, collagen and interleukin synthesis. In this
Enhanced micromotions between the implant and surrounding bone can impair osseointegration, resulting in fibrous encapsulation and aseptic loosening of the implant. Since the effect of micromotions on human bone cells is sparsely investigated, an Micromotions ranging from 25 µm to 100 µm were applied as sine or triangle signal with 1 Hz frequency to human osteoblasts seeded on collagen scaffolds. Micromotions were applied for six hours per day over three days. During the micromotions, a static pressure of 527 Pa was exerted on the cells by Ti6Al4V cylinders. Osteoblasts loaded with Ti6Al4V cylinders and unloaded osteoblasts without micromotions served as controls. Subsequently, cell viability, expression of the osteogenic markers collagen type I, alkaline phosphatase, and osteocalcin, as well as gene expression of osteoprotegerin, receptor activator of NF-κB ligand, matrix metalloproteinase-1, and tissue inhibitor of metalloproteinase-1, were investigated.Objectives
Methods
The influence of the bone mineral density (BMD) on the mechanical behavior of bones can be examined using computer tomography (CT) data and finite element (FE) simulations, because the BMD correlates with the Hounsfield scale (HU) of the CT data. Therefor the material mapping strategy, which is required to assign the HU values to the FE mesh, is of crucial importance. In this study a nodal mapping strategy was analyzed concerning its sensitivity towards FE mesh parameters and an averaging of HU values from the area around the respective nodes. The FE simulation is based on CT data of a human proximal femur. Once the bone shape was reconstructed, the resulting model was meshed with quadratic tetrahedral elements in ABAQUS/CAE and all nodes were assigned an HU value from the CT data by using the respective node coordinates. In this process, the mesh density, the threshold, which could be used to exclude connective tissue and fat from the material mapping process, the considered volume around the nodes and the method of averaging were varied. The material assignment was realized by an HU value dependent, linear elastic material definition. The femur model was clamped at the level of the isthmus and a displacement of 0.5 mm was applied at the femoral head. The evaluation was based on the resulting reaction forces.Introduction
Method
Many pateints showed an extented survival despite disseminated disease with a high and quality of life. Radical resection as tried in a few patients did not proof to be beneficial regarding the prognsotic effect.
