Introduction

A significant burden of disease exists with respect to critical sized bone defects; outcomes are unpredictable and often poor. There is no absolute agreement on what constitutes a “critically-sized” bone defect however it is widely considered as one that would not heal spontaneously despite surgical stabilisation, thus requiring re-operation. The aetiology of such defects is varied. High-energy trauma with soft tissue loss and periosteal stripping, bone infection and tumour resection all require extensive debridement and the critical-sized defects generated require careful consideration and strategic management. Current management practice of these defects lacks consensus. Existing literature tells us that tibial defects 25mm or great have a poor natural history; however, there is no universally agreed management strategy and there remains a significant evidence gap. Drawing its origins from musculoskeletal oncology, the Capanna technique describes a hybrid mode of reconstruction. Mass allograft is combined with a vascularised fibula autograft, allowing the patient to benefit from the favourable characteristics of two popular reconstruction techniques. Allograft confers initial mechanical stability with autograft contributing osteogenic, inductive and conductive capacity to encourage union. Secondarily its inherent vascularity affords the construct the ability to withstand deleterious effects of stressors such as infection that may threaten union. The strengths of this hybrid construct we believe can be used within the context of critical-sized bone defects within tibial trauma to the same success as seen within tumour reconstruction.

MOXIMED KineSpring® Knee Implant System is an Orthopaedic device designed for younger or highly active patients with osteoarthritis. The device is placed under the skin, is attached to the tibia and femur, and contains springs which help limit some of the forces that are transmitted through the knee during activities such as walking or running and thereby relieve pain that may be experienced by patients with early arthritis of the knee. The aim of this study is to determine the long term safety and efficacy of the KineSpring knee implant system.

This is a prospective case series involving two centres in Glasgow. 29 patients (mean age of 45.1 years and range 18-65 years) were recruited into the study between 2011 and 2016. The Primary outcome measure was Oxford knee score (OKS) at 2, 5 and 10 years post-operatively. Secondary outcome measures include device related complications and survival, patient reported functional outcome measures, patient satisfaction, pain levels and change in radiographic classification of osteoarthritis

At 2-year follow-up, 7 implants were removed (74.1% survival). Complications include deep infection, requiring removal in 1 patient, 2 implant failures requiring removal and one spring breakage. In comparison to pre-operative measures there was an improvement in the pain (3.58 vs. 5.20, p=0.02), stiffness (4.16 vs. 4.47, p=0.6) and OKS (32.4 vs. 36.9, p=0.03).

The KineSpring improves overall pain, stiffness and functional outcome at 2 years following surgery, however there was a high rate of removal and further long-term follow up analysis is required regarding its effectiveness.

Tranexamic acid (TXA) is an anti-fibrinolytic medication commonly used to reduce peri-operative bleeding. Increasingly, topical administration as an intra-articular injection or peri-operative wash is being administered at concentrations between 10–100mg/ml. This study investigated effects of TXA on human periarticular tissues and primary cell cultures using clinically relevant concentrations.

Tendon, synovium and cartilage obtained from routine orthopaedic surgeries were used ex vivo or cultured for in vitro studies using various concentrations of TXA. They were stained with 5-chloromethylfluorescein diacetate and propidium iodide and imaged using confocal microscopy to identify the proportion of live and dead cells. The in vitro effect of TXA on primary cultured tenocytes, synovial like fibroblast (FLS) cells and chondrocytes was investigated using cell viability assays (MTT), fluorescent microscopy and multi-protein apoptotic arrays for cell death.

There was significant (p<0.01) increase in cell death in all tissue treated with 100mg/ml TXA, ex vivo. MTT assays revealed significant (p<0.05) decrease in cell viability following treatment with 50 or 100mg/ml of TXA within 4 hours of all cell types cultured in vitro. Additionally, there was significant (p<0.05) increase in cell apoptosis detected by fluorescent microscopy within 1 hour of exposure to TXA. Furthermore, multi-protein apoptotic arrays detected increased apoptotic proteins within 1 hour of TXA treatment in tenocytes and FLS cells.

Our study provides evidence of TXA cytotoxicity to human peri-articular tissues ex vivo and in vitro at concentrations and durations of treatment routinely used in clinical environments. Clinicians should therefore show caution when considering use of topical TXA administration.

The Medial Patellofemoral Ligament (MPFL) is the main restraining force against lateral patellar displacement. It is often disrupted following patellar subluxation or dislocation. MPFL reconstruction is frequently performed when conservative management fails and the patient experiences recurrent patellar dislocation. Various MPFL reconstruction procedures have been described in the literature and reported outcomes are encouraging. This study analyses the radiographic outcomes following MPFL reconstruction.

From January 2006 to January 2011, 76 consecutive patients (80 knees) with patellar recurrent dislocation underwent medial patellofemoral ligament reconstruction in three large teaching hospitals. Mean follow-up was 31.8 months (range, 13–72). Semitendinosus and gracilis autografts were used for the reconstruction and all procedures were carried out by the senior authors (WL, BR, CW, MB).

Plain radiographs (Anteroposterior (AP), Lateral and Skyline) performed preoperatively and postoperatively were used to compare the sulcus angle, congruence angle, lateral patellofemoral angle, trochlear dysplasia (Dejour classification), trochlear boss height and patellar height (Caton-Deschamps ratio). Plain radiographs (Lateral) performed postoperatively were used to evaluate the femoral tunnel placement used for MPFL reconstruction.

The sulcus angle improved from 143.2° (122.9–157.7) to 139.3° (115.7–154.6) and the congruence angle improved from 26.7° (−17.5–82.6) to 0.26° (−35.3–7.8). The lateral patellofemoral angle was 7.99° (3.2–19.2) preoperatively and 9.02° (3.2–18.2) postoperatively. The Caton-Deschamps ratio was 1.2 (1.0–1.5) preoperatively and 1.0 (0.8–1.1) postoperatively. Using the Dejour classification of trochlear dysplasia, all preoperative radiographs were considered to be grade C or D and all postoperative radiographs were considered to be grade A or B. Trochlear boss height was 5.9mm (1.8–11.6) preoperatively and 4.7mm (1.6–6.9) postoperatively. 59% of the femoral tunnels were considered to be in a good position on postoperative radiographs.

This study displayed a significant improvement in postoperative radiographic parameters, demonstrating the importance of anatomic restoration when performing MPFL reconstruction.

We report the short term follow up of nineteen consecutive PFC sigma unicompartmental knee replacements carried out in our institution with minimum one year follow up. The PFC Sigma medial unicompartmental knee replacement is a fixed bearing, cemented unicompartmenal knee replacement. There are currently no published reports of follow up for the PFC Sigma medial unicompartmental knee replacement.

Nineteen patients (nineteen knees) underwent PFC sigma medial unicompartmental knee arthroplasty. The pre-operative diagnosis was osteoarthritis in eighteen patients and osteonecrosis in one patient. There were ten males and nine females with a mean age of sixty four years. All patients had clinical and radiological review at one year. All operations were carried out by the two senior authors (BPR and BL).

The mean length of admission was 2.7 days (Range 2–5). There have been no infective or thromboembolic complications to date. The mean oxford scores improved from 41 (Range 26–52) pre-operatively to 18 (15–27) at one year follow-up. The mean range of motion improved from 115 degrees of flexion preoperatively to 125 degrees. All radiographs were satisfactory at one year follow up with no evidence of loosening.

We report the promising early results of a new medial unicompartmental knee replacement with at least one year follow up. No early complications or infections were identified in our cohort of patients.

Aim

We aim to compare post-operative length of stay and cardiopulmonary morbidity in patients randomised to either navigated or conventional total knee arthroplasty (TKA).

Aim

We aim to compare revision rates and functional outcome scores in between two contemporary total knee arthoplasty systems.

Aim

This study looks for correlation between pre-operative MRI and intra-operative surgical findings regarding the site of medial patellofemoral ligament (MPFL) rupture in first time patella dislocaters with the aim of confirming the reliability of this modality of imaging.

The objective was to seek evidence of hypoxia in early human tendinopathy and thereafter, to explore mechanisms whereby tissue hypoxia may regulate apoptosis, inflammatory mediators and matrix regulation in human tenocytes.

Fifteen torn supraspinatus tendon (established pathology) and matched intact subscapularis tendon (representing ‘early pathology’) biopsies were collected from patients undergoing arthroscopic shoulder surgery. Control samples of subscapularis tendon were collected from 10 patients undergoing arthroscopic stabilisation surgery. Markers of hypoxia were quantified by immunohistochemical methods. Human tendon-derived primary cells were derived from hamstring tendon tissue obtained during hamstring tendon ACL reconstruction. The impact of hypoxia upon tenocyte biology ex vivo was measured using quantitative RT-PCR, multiplex cytokine assays, apoptotic proteomic profiling, immunohistochemistry and annexin V FACS staining.

Increased expression of HIF 1a, Bcl-2 and clusterin (hypoxic and apoptotic markers) was detected in subscapularis tendon samples compared to both matched torn samples and non matched control samples (p<0.01). Hypoxic tenocytes exhibited increased production of proinflammatory cytokines (p<0.001), altered matrix regulation (p<0.01) with increased production of Collagen type III operating through a MAPK dependent pathway. Finally, hypoxia increased expression of several mediators of apoptosis and thereby promoted tenocyte apoptosis.

Hypoxia promotes expression of proinflammatory cytokines, key apoptotic mediators and drives matrix component synthesis towards a collagen type III profile by human tenocytes. We propose hypoxic cell injury as a critical pathophysiological mechanism in early tendinopathy offering novel therapeutic opportunities in the management of tendon disorders.

We aim to compare post-operative length of stay and cardiopulmonary morbidity in patients randomised to either navigated or conventional total knee arthroplasty (TKA).

Patients undergoing primary TKA for osteoarthritis were prospectively assigned randomly to either navigation-guided or control groups and blinded to this.

All patients received a PFC implant (DePuy, Warsaw, IN). In the control group the standard femoral intramedullary and tibial extramedullary alignment rod was used. In the navigation group, the BrainLab (Munich, Germany) navigation system was used. All operations were carried out by one of two consultant orthopaedic knee surgeons.

Length of post operative hospital stay and the development of cardiopulmonary complication were recorded and groups compared.

100 patients were recruited (55 control vs 45 navigated). Patient demographics were similar in both groups.

Mean length of stay was 7 days in the control group (range 3-101), 5 days in the navigation group (range 3-10). The mode was 4 days in both groups.

7 patients (13%) stayed for >7 days in the control group, 3 patients (7%) stayed >7 days in the navigation group(p=0.339).

4 patients(7%) required >10 days inpatient stay in the control group, 0 patients required to stay in hospital for longer than 10 days in the navigation group(p=0.069).

The causes for the length of stay exceeding 10 days were pulmonary embolus in 3 patients, and chest infection in 1 patient.

Patients undergoing navigation-guided TKA required shorter post-operative inpatient stays than those undergoing arthroplasty using conventional techniques. Fewer patients in the navigation group required stays longer than 7 or 10 days. The difference in post-operative stay was associated with fewer respiratory complications in the navigated group.

The medial patellofemoral ligament is commonly torn in first patella dislocation and according to the literature occurs most frequently at the femoral insertion. As research has demonstrated the MPFL to be a primary soft tissue stabilizer of the patella there has been increased interest in acute repair of the ligament with the aim of reducing the risk of recurrent dislocation. MRI is generally used pre op to identify the site of rupture allowing planning of the surgical repair, however there is currently no published data regarding the correlation between surgical and MRI findings to confirm the reliability of this modality of imaging.

A retrospective analysis of all patients who were referred for MRI following patella dislocation was performed. The surgical and MRI findings of those who subsequently underwent MPFL repair were compared to look for any correlation. 41 patients were first time patella dislocators and 38 had MPFL rupture diagnosed on MRI. Of these 19 progressed to surgical intervention and 17 had adequate data available from the notes and to permit comparison. All of the MPFLs ruptured at the patella insertion. In 76.5% (13/17) of patients the site of MPFL rupture was correctly identified on MRI scan. Of those that were discordant 3/4 had the site of rupture identified as the femoral insertion on MRI and on 1/4 the MRI suggested rupture at both the femoral and patella insertions.

MPFL rupture is common in first time dislocations occurring in 93%% of this cohort. There was a clear predominance patella insertion rupture in our study which contrasts with the majority of the published literature. By correlating surgical and radiological findings we can conclude that while MRI can accurately diagnose MPFL rupture at the patella insertion but it is less accurate in identifying rupture at the femoral insertion.

Aims: The results of open reduction and internal þxation of 24 unstable dorsally displaced fractures of the distal radius are reported. Methods: The fractures occurred in 24 patients (mean age 39) and 17 of these fractures were AO Type C. All fractures were treated with open reduction and subperiosteal placement of dorsal 2.0mm or 2.7mm AO mini-fragment plates between 1st and 2nd dorsal compartments and below the 4th compartment. Additional volar plate þxation was required in 6 cases. Patients were examined and X-rays performed. Outcome was assessed using the Modiþed Mayo Wrist Score and Patient Evaluation Measure. Results: At þnal follow-up (mean 36 months), the mean range of movement of the wrist was: extension 78¡, ßexion 64¡, pronation 82¡ and supination 83¡. Grip strength averaged 84% of the unaffected side. Radiographic assessment showed a mean volar angle of 8¡, articular step in 5 cases and evidence of osteoarthritis in 10 wrists.

The þnal outcome, using the Modiþed Mayo Wrist Score was excellent in 13 cases, good in 7, and fair in 4 cases. Complications were seen in 3 patients and metalwork has subsequently been removed in 7 patients for tendon irritation but there have been no cases of extensor tendon rupture. Conclusions: This initial experience has encouraged the use of open reduction and dorsal plating as the treatment of choice in young patients with unstable and/or intra-articular fractures of the distal radius. With time, range of movement and grip strength, continue to improve.

Tuberosity ‘avulsion’ fractures to the base of the fifth metatarsal respond well to symptomatic treatment. The purpose of this study was a prospective comparison of clinical and radiological outcome with treatment in a plaster slipper, compared to a tubigrip support.

Ethical approval was obtained and written consent with an information sheet issued at the first fracture clinic appointment. Forty three patients with this fracture were allocated to one of our two treatment groups and followed up at regular intervals over a 12 week period or until they were suitable for discharge. A combined foot score (maximum 100 points) was used at each follow up appointment to measure levels of pain (40 points) and function (60 points). A check radiograph was taken prior to discharge to assess union. A repeated measures analysis was used to assess any difference between the two treatment groups and whether this changed with time.

Results indicated no overall significant difference between the two treatment groups with a mean foot score of 73.5 for the tubigrip group and 80.3 for the plaster slipper group over the entire treatment period. At 2 weeks post injury the plaster group (70.9) had a significantly (p< 0.01) better combined foot score at assessment in comparison to the tubigrip group (54.1).By the 5–8 week stage, the mean combined foot scores had improved and were comparable at 89.5 (tubigrip) and 90 (plaster slipper). Radiographs taken prior to discharge indicated two patients in each treatment group with significant fracture site displacement. One patient remained clinically symptomatic and underwent surgical fixation.

In this small cohort of patients the eventual clinical and radiological outcomes were comparable. During the initial 2 week treatment phase the plaster slipper group recorded a significantly better mean foot score.