Aims: Clinical and radiographic comparison between a fixed polyethylene prostheses and mobile bearing design. Methods: Prospective study in 147 tricompartimental cemented cruciate-retaining prostheses (Interax, Stryker- Howmedica-Osteonics): 90 conventional fixed polyethylene and 57 mobile bearing (antero-posterior slide and rotation over an axis in the medial plateau). No differences in preoperative age, sex, range of motion, deformity, rheumatoid arthritis or osteo-arthritis, and Ahlback stage. Results: At 1, 6, 12 and 24 months there were no differences between both groups (p> 0.05) in femorotibial angles, radiolucencies, duration of surgery, pain at rest or walking, stairs, arise from chair, walking ability, range of motion, supports (cane or crutches), complications and score of the American Knee Society. Conclusions: With 2-year follow-up there are no differences in clinical or radiographic results between fixed and mobile bearing knee prostheses. Further investigations with long-time follow-up are mandatory in order to determine differences and advantages in polyethylene wear or implant survival.