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Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_16 | Pages 18 - 18
17 Nov 2023
Gallagher H Naeem H Wood N Daou HN Pereira MG Giannoudis PV Roberts LD Howard A Bowen TS
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Abstract

Introduction

Skeletal muscle wasting is an important clinical issue following acute traumatic injury, and can delay recovery and cause permanent functional disability particularly in the elderly. However, the fundamental mechanisms involved in trauma-induced muscle wasting remain poorly defined and therapeutic interventions are limited.

Objectives

To characterise local and systemic mediators of skeletal muscle wasting in elderly patients following acute trauma.