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Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_14 | Pages 59 - 59
1 Dec 2019
Giannitsioti E Salles M Mavrogenis A Rodríguez-Pardo D Pigrau C Ribera A Ariza J Toro DD Nguyen S Senneville E Bonnet E Chan M Pasticci MB Petersdorf S Soriano A Benito N Connell NO García AB Skaliczki G Tattevin P Tufan ZK Pantazis N Megaloikonomos PD Papagelopoulos P Papadopoulos A
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Aim

Gram negative bacteria (GNB) are emerging pathogens in chronic post-traumatic osteomyelitis. However, data on multi-drug (MDR) and extensively drug resistant (XDR) GNB are sparse.

Methods

A multi-centre epidemiological study was performed in 10 countries by members of the ESGIAI (ESCMID Study Group on Implant Associated Infections). Osteosynthesis-associated osteomyelitis (OAO) of the lower extremities and MDR/XDR GNB were defined according to international guidelines. Data from 2000 to 2015 on demographics, clinical features, microbiology, surgical treatment and antimicrobial therapy were retrospectively analyzed. Cure was assessed after the end of treatment as the absence of any sign relevant to OAO. Factors associated with cure were evaluated by regression analysis.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_17 | Pages 91 - 91
1 Dec 2018
Papadopoulos A Ribera A Mavrogenis A Rodríguez-Pardo D Bonnet E Salles M del Toro MD Nguyen S García AB Skaliczki G Soriano A Benito N Petersdorf S Pasticci MB Tattevin P Tufan ZK Chan M Connell NO Pantazis N Pigrau C Megaloikonomos PD Senneville E Ariza J Papagelopoulos P Giannitsioti E
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Aim

Data on Prosthetic joint infection (PJI) caused by multi-drug resistant (MDR) or XDR (extensively drug resistant) Gram negative bacteria (GNB) are limited. Treatment options are also restricted. We conducted a multi-national, multi-center assessment of clinical data and factors of outcome for these infections.

Method

PJI were defined upon international guidelines. Data from 2000–2015 on demographics, clinical features, microbiology, surgical treatment and antimicrobial therapy was collected retrospectively. Factors associated with treatment success were evaluated by logistic regression analysis.