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Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_21 | Pages 93 - 93
1 Dec 2016
Mulpuri K Dobbe A Schaeffer E Miyanji F Alvarez C Cooper A Reilly C
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Closed reduction and percutaneous pinning has become the most common technique for the treatment of Type III displaced supracondylar humerus fractures in children. The purpose of this study was to evaluate whether the loss of reduction in lateral K wiring is non-inferior to crossed K wiring in this procedure.

A prospective randomised non-inferiority trial was conducted. Patients aged three to seven presenting to the Emergency Department with a diagnosis of Type III supracondylar humerus fracture were eligible for inclusion in the study. Consenting patients were block randomised into one of two groups based on wire configuration (lateral or crossed K wires). Surgical technique and post-operative management were standardised between the two groups. The primary outcome was loss of reduction, measured by the change in Baumann's angle immediately post –operation compared to that at the time of K wire removal at three weeks. Secondary outcome data collected included Flynn's elbow score, the humero-capitellar angle, and evidence of iatrogenic ulnar nerve injury. Data was analysed using a t-test for independent means.

A total of 52 patients were enrolled at baseline with 23 allocated to the lateral pinning group (44%) and 29 to the cross pinning group (56%). Six patients (5 crossed, 1 lateral) received a third wire and one patient (crossed) did not return for x-rays at pin removal and were therefore excluded from analysis. A total of 45 patients were subsequently analysed (22 lateral and 23 crossed). The mean change in Baumann's angle was 1.05 degrees, 95% CI [-0.29, 2.38] for the lateral group and 0.13 degrees, 95% CI [-1.30, 1.56] for the crossed group. There was no significant difference between the groups in change in Baumann's Angle at the time of pin removal (p = 0.18). Two patients in the crossed group developed post-operative iatrogenic ulnar nerve injuries, while none were reported in the lateral group.

Preliminary analysis shows that loss of reduction in Baumann's angle with lateral K wires is not inferior to crossed K wires in the management of Type III supracondylar humerus fractures in children. The results of this study suggest that orthopaedic surgeons who currently use crossed K wires could consider switching to lateral K wires in order to reduce the risk of iatrogenic ulnar nerve injuries without significantly compromising reduction.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_20 | Pages 68 - 68
1 Nov 2016
Miyanji F Reilly C Desai S Samdani A Shah S Asghar J Yaszay B Shufflebarger H Betz R Newton P
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Most long-term follow-up studies report retrospective data, the quality of which remains limited due to their inherent biases. Prospective databases may overcome these limitations, however, feasibility and costs limit their application. To date there exists a paucity of evidence-based literature on which recommendations can be made for the ideal length of follow-up for spinal deformity research. Therefore, our aim was to evaluate the added value of follow-up of patients beyond 2 years following surgery for AIS.

A database registry evaluating surgical outcomes for all consecutive AIS patients with post-op data-points of 6 months, 1 year, 2 year, and 5 year was analysed. Surgeon-reported complications, SRS-22 scores, and radiographic data were evaluated. Complications requiring surgical or medical intervention were compared between patients in whom complications developed within 2 years to those in which newly developed complications occurred between >2–5 years.

536 patients were analysed. SRS-22 scores significantly improved at 2 years post-op with no change at 5-year follow-up. Overall complication rate was 33.2% with majority occurring within 2 years (24.8%). The rate of complications occurring >2–5 years requiring intervention was significantly lower than those requiring intervention within 2 years of surgery (4.7% vs 9.7%, p=0.000), however was not negligible. The most common newly observed complication beyond 2 years was pain (1.9%), followed by surgical site infection (SSI) (1.3%) and implant issues (0.56%). There were no significant differences in the rates of crankshaft (p=0.48), implant issues (p=0.56), pseudarthrosis (p=0.19), and SSI (p=0.13) between the 2 time points.

Although majority of complications following AIS surgery occurs within 2 years, a non-negligible rate of newly observed complications occur at >2–5 years post-op. Specifically crankshaft, pseudarthrosis, implant issues, and SSI have similar rates of occurrence at these 2 time points.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_20 | Pages 26 - 26
1 Nov 2016
Larouche P Andrade J Reilly C Mulpuri K
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A commonly misunderstood principle in medical literature is statistical significance. Often, statistically non-significant or negative results are thought to be evidence for equivalence; mistakenly validating treatment modalities and putting patients at risk. This study examines the prevalence of misinterpretation of negative results of superiority trials in orthopaedic literature and outlines the need for a non-inferiority or equivalence research design.

Four orthopaedic journals – Journal of Paediatric Orthopaedics A, Journal of Bone and Joint Surgery American Volume, Journal of Arthroplasty and Journal of Shoulder and Elbow Surgery – were hand searched to identify all randomised control trials (RCTs) published within the time periods 2002–2003, 2007–2008 and 2012–2013. The identified RCTs were read and classified by study methodology, results obtained, and interpretation of results.

A total of 237 RCTs were identified. When analysing the primary outcomes, 117 (49.4%) studies yielded negative results and 120 (50.8%) yielded positive results. Out of the 237 articles, 231 (97.5%) used superiority methodology and 6 (2.5%) used non-inferiority or equivalence methodology. Of the 231 studies that used superiority methodology, 115 (49.8%) obtained negative results; and 45 (39.1%) of those misinterpreted the negative results for equivalence. While no statistical differences were seen, there was an upward trend in utilising non-inferiority and equivalence methodologies over time.

Given the frequency of misinterpreted negative results, there is an evident need for a more appropriate research methodology that shows equivalence of treatment methods. A non-inferiority or equivalence study design can address orthopaedic clinical dilemmas more suitably when trying to show one treatment is no worse or is equal to another treatment. Regarding orthopaedic treatment modalities as equivalent when studies show negative statistical results can be detrimental to patients and their clinical outcomes. A non-inferiority methodology can be used to accurately depict no difference between treatment methods rather than attempting to show one treatment method as superior.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_20 | Pages 74 - 74
1 Nov 2016
Miyanji F Reilly C Shah S Clements D Samdani A Desai S Lonner B Shufflebarger H Betz R Newton P
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Natural history of AIS >30° in skeletally mature patients is poorly defined. Studies reporting rates and risk factors for progression are predominantly of large curves in immature patients. Our aim was to determine the rate of curve progression in AIS following skeletal maturity, any associated changes in SRS-22 scores, and identify any potential predictors of curve progression.

Patients enrolled in a prospective, longitudinal, multicentre non-surgical AIS database were evaluated. All patients had minimum 2 year follow-up, idiopathic scoliosis >30°, and were skeletally mature. SRS-22 functional outcome scores and radiographic data were compared at baseline and 2-year follow-up. Patients were divided into 3 groups based on curve size: A=30°-39°, B=40°-49°, C= >50°. Curve progression was defined as any change in curve magnitude.

There were 80 patients, majority females (93.8%) with a mean age of 16.5+/−0.16. Mean BMI was 21+/−0.31 with 15.1% overweight. Mean major cobb at baseline was 38.3°+/−0.88°. At 2 year follow-up 46.3% of curves had progressed an average 3.4°+/−0.38°. Of curves that progressed, patients in group A had the largest mean rate of progression followed by group B. SRS-22 scores on average declined significantly over 2 years in this cohort (4.23 to 4.08; p=0.002). Patients who progressed had on average a more significant decline in SRS outcome scores compared to those that did not (p=0.018, p=0.041 respectively), with the most significant change noted in the Self-Image domain (p=0.03). There was no significant difference in the change in SRS scores over 2 years based on curve size. Univariate analysis did not identify any factors predictive of curve progression in this cohort.

Skeletally mature patients with AIS >30°may continue to have a risk of progression at a mean rate of 1.7°/yr and significant decline in SRS-22 outcome scores, in particular Pain and Self-Image, over time.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_15 | Pages 8 - 8
1 Sep 2016
Aarvold A Fortes C Chhina H Reilly C Wilson D Mulpuri K Cooper A Uglow M
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This pilot study aims to investigate the utility and feasibility of a unique upright MR scan for imaging hips affected by Legg-Calve-Perthes Disease (LCPD) with patient standing up, in comparison to the standard supine scans.

Protocol development using this unique upright MRI included healthy adult and child volunteers. Optimum patient positioning in a comparable way between supine to standing was assessed. The balance between shorter scan time (to what a child can tolerate) and longer scan time (for better image acquisition). The study protocol has begun in 2 children with LCPD. Patient recruitment continues.

Early results indicate a dynamic deformity of the femoral head in early stage LCP disease. Femoral epiphysis height decreased on standing (7.8 to 6.8mm), width increased on standing (16.6 to 20.9mm) and lateral extrusion increased (3.5 to 4.1mm). Overall epiphyseal shape changed from trapezoidal (LCP femoral head when supine) to flattened triangular (LCP femoral head when standing). Differences were thus demonstrated in all parameters of bony epiphyseal height, width, extrusion and shape of a femoral head with LCP Disease when the child stood and loaded the affected hip.

Satisfactory image acquisition was possible with Coronal T1 GFE sequences, with both hips in the Field of View. 2.5min scans were performed with the child standing first, then supine. Hip position was comparable when standing and supine. Longer scans were not tolerated by younger children, more so those with LCP disease.

To our knowledge this is the first reported use of standing MRI in LCPD. A dynamic deformity has been demonstrated, with flattening, widening and worsened lateral extrusion when the child is standing compared to supine. This proof of concept investigation demonstrates the feasibility of upright MRI scanning and may demonstrate previously undetected deformity.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 146 - 146
1 Mar 2008
Mulpuri K Tredwell S Choit R Reilly C
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Purpose: The purpose of this study was to assess the clinical, radiological, and functional outcomes following the treatment of a lumbar Chance fracture and to analyze the spectrum of associated abdominal injuries as seen in the Seat Belt Syndrome.

Methods: All patients diagnosed with L1 to L4 Chance fractures were included in this study. Patient data, injuries, treatment and complications were collected from hospital charts. A review of all available spinal radiology was done to measure pre-treatment, post-treatment and follow-up kyphosis angles. We have also described and calculated a Chance Fracture Deformity Index. Patients were seen in follow-up to assess for range of motion, tenderness and neurological status. A functional outcome questionnaire by the AAOS Pediatric Instruments was completed by the patients.

Results: Between December 1984 and February 2001, 27 patients aged 3 to 17 were treated for lumbar Chance fractures. The mean age at injury was 11.1 years. There were 17 females and 8 males. All injuries occurred as a result of a motor vehicle accident. Of the 25 patients, 17 were treated surgically. 12 patients had abdominal injuries. 3 cases involved abdominal arterial vascular trauma. Significant improvement in intra-vertebral kyphosis, segmental kyphosis, and vertebral kyphosis redmodelling (6.5 vs. 4 degrees) was noted in the operative group compared to the non-operative group. The disease specific AAOS Lumbar Spine Questionnaire scores were poor for pain and disability, 29.22, (26.41–31.98), but the SF-36 scores for both MCS and PCS were within the normal range, 47.79 (44.03–51.54) and 47.71 (42.59–52.82), respectively.

Conclusions: An abdominal and spinal CT must be taken when presented with a Chance fracture with abdominal symptoms. Injury type and kyphosis angle are the main factors that aid in treatment planning in paediatric lumbar chance fractures. A purely soft-tissue injury or a kyphosis angle greater than 20 requires surgical intervention.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 117 - 117
1 Mar 2008
Reilly C Choit R Slobogean G
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This study examined clinical and radiological outcomes following video assisted thoracoscopic surgery (VATS) for anterior release and fusion in the correction of paediatric scoliotic deformities. Nineteen patients who underwent VATS were compared with nineteen open thoracotomy patients to compare degree of correction and perioperative morbidity. Demographic parameters were similar between the groups and there was no significant difference in operative time or total blood loss. VATS offered the same degree of correction as open thoracotomies and has the potential to decrease post-operative morbidity while still allowing the same degree of correction as traditional open thoracotomies.

To compare the peri-operative parameters and outcomes of video-assisted thoracoscopic surgery (VATS) with open thoracotomy for anterior release and fusion in the treatment of paediatric spinal deformities.

VATS is a good alternative to open thoracotomy.

VATS has the potential to decrease post-operative morbidity while still allowing the same degree of correction as traditional open thoracotomies.

There were nineteen patients in each group, seventeen with idiopathic scoliosis in the VATS group and sixteen in the open group. Mean age, weight at surgery and pre-operative Cobb angle were similar (p=1.000, 0.8277, 0.0636, respectively). There was no significant difference in operative time per level between the VATS group and the open group (37.2 vs. 34.5 min, p= 0.2254) or total blood loss (908 vs. 823 ml, p= 0.4953). There were no major complications encountered in the VATS group, one patient in the open group experienced atelectasis and subsequent lower lobe collapse.

A detailed chart and radiographic review was undertaken to determine degree of correction, perioperative morbidity and complications, if any, of patients who underwent VATS between 1997 and 2004 at the author’s institution. A control group of patients who underwent open thoracotomy was used to determine if is there a significant difference in correction (Cobb angle) or in perioperative morbidity when using VATS versus open thoracotomy for anterior release and fusion in the correction of scoliotic deformities.

It appears that VATS offers the same degree of correction as open thoracotomies.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 292 - 293
1 Sep 2005
Reilly C Tredwell S LeBlanc J Mulpuri K Sajhal V
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Introduction and Aims: The anterior approach to dealing with complex spinal deformities around the cervical thoracic junction presents a surgical challenge. With the help of a cardiothoracic surgeon, a sternal splitting technique was utilised in five paediatric patients to resolve this difficulty and gain access to spinal deformities around the cervical thoracic junction.

Method: A longitudinal incision is made parallel to the sternocleido muscle and extended across the sternum for a median sternotomy. The sternocleido muscles are retracted to the lateral aspect of the incision. The carotid and jugular vein are dissected out. To continue with the dissection and exposure of the upper thoracic spine, a full sternotomy is done. The sternum is opened. The dissection of the right carotid is extended over the innominate artery, including the bifurcation of the right subclavian artery. The jugular vein is dissected out coming down to the superior vena cava. The innominate vein is isolated. The lower end of the anterior scalenus muscle is divided up.

Results: This technique was employed in five paediatric patients, aged three to 15 years, at the authors’ institution. Diagnoses included Klippel-Feil Syndrome, Proteus Syndrome, Larsen Syndrome and, Neurofibromatosis (two patients). All patients had severe cervical thoracic kyphosis requiring surgical instrumentation. This technique resulted in a range of access from C5 to T6 being granted. In one patient, a separate thorocotemy was performed in order to gain access to the lower thoracic spine.

Conclusion: This approach was invaluable in gaining access to the cervical thoracic junction to address complex spinal deformities. Access to the lower cervical and the upper thoracic spine is granted. No significant complications occurred. The aid of a cardiothoracic surgeon is advised.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 319 - 320
1 Sep 2005
Reilly C Mulpuri K
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Introduction and Aims: The aim of this paper is to review C1-C2 facet screw use in paediatric patients and to demonstrate that the technique plays an important role in patients with underlying anatomic abnormalities, which are common in children with cervical instability.

Method: A chart review was conducted of all patients managed with C1-C2 facet screws from January 1, 1996 until July 30, 2003 present in the case database. All radiographs were obtained and reviewed. Post-operative and follow-up films were assessed for acceptable screw position and evidence of fusion.

Results: C1-C2 facet screws were utilised in nine patients at British Columbia’s Children’s Hospital. The youngest patient treated was five years of age with a mean age for the group of 12. The group consisted of three Down syndrome patients and six with Os Odontoidium, two of which failed previous C1-C2 fusion. Two patients presented with an acute spinal cord injury. Pre-operative CT or MR imaging was used in all patients.

Screw placement was unacceptable in one case. Post-operative Halo immobilisation was used in seven patients. Post-operative complications included one wound infection and four halo pin infections requiring treatment. No patients have required surgery at a mean follow-up of four years. C1-C2 facet screws are an important adjunct in a paediatric spine practice. This technique has a great advantage in Down syndrome patients who have a high rate of pseudoarthosis because of: ligamentous laxity, non-compliance with immobilisation and a high incidence of congenital deformities such as os odontoidium and incomplete posterior arch of C1.

Conclusion: C1-C2 facet screws can be safely used in young children. The screws allow for fixation in the absence of an intact posterior arch. The technique has a great advantage in Down syndrome patients who have a high rate of pseudoarthosis due to congenital deformities, ligamentous laxity and non-compliance with immobilisation


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 296 - 296
1 Sep 2005
Reilly C
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Introduction and Aims: The aim of this paper is to review an innovative anterior technique to address double major scoliotic deformities in paediatric patients. This technique, which utilises modified lumbar anterior rod placement followed by an overlapped thoracic rod placed in the concavity of the thoracic curve, may have a considerable role in managing double major scoliotic deformities.

Method: All patients undergoing double anterior rod instrumentation for idiopathic scoliosis at the author’s institution were reviewed. They were closely assessed and reviewed for any negative effects. Radiographs were evaluated for correction of the scoliotic deformity and correction of the obliquity of the end vertebra. Disc space fusion was also evaluated on follow-up films.

Results: Patients requiring thoracic and lumbar instrumentation were considered for the technique. Mean pre-operative curve sizes were 53 and 59 degrees for the thoracic and lumbar curves, respectively. The described operative technique utilises a modified lumbar anterior rod placement followed by an overlapped thoracic rod placed in the concavity of the thoracic curve. Thoracic vessels are preserved in this technique. Mean operative time was 7.5 hours.

Anterior instrumentation has been completed in five patients at the author’s institution. Obliquity of L3 was corrected from a mean of 29 degrees pre-operatively to five degrees post-operatively. No patients had significant decompensation nor did they require any further procedure. No post-operative complications occurred. The technique allows for one incision instrumentation of double major curves to the lower end vertebra, preserving the L3-4 motion segment.

Conclusion: Anterior instrumentation is useful in patients with double major scoliotic deformities who require thoracic and lumbar instrumentation. This new technique may have a significant role in the management of a subset of idiopathic scoliosis patients as it preserves the L3-L4 motion segment, while allowing one-incision instrumentation of double major curves.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 349 - 349
1 Sep 2005
Reilly C Mulpuri K Saran N Choit R
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Introduction and Aims: The aims of this study were to compare the over-the-top and four-strand techniques of paediatric anterior cruciate ligament reconstruction. An age and sex-matched control study of these two different ACL reconstructive techniques was done to determine if there are differences in instability, functional outcomes and growth plate-related problems.

Method: Injuries, treatment and associated complications were collected from hospital charts. Pre-operative x-rays were used to determine growth plate status both at the distal femur and the proximal tibia. Pre-operative MRIs were studied to assess the position and nature of mid-substance ACL tear and any associated meniscal tear or pathology. Follow-up included examination as per International Knee Documentation Committee guidelines, including patient history and a clinical examination assessing the degree of anterior draw, presence and quality of a pivot shift test and pivot glide, and arthrometric measurements using the KT-1000 Arthrometer for anterior translational distance in millimetres. The Lysholm questionnaire was completed by all patients.

Results: Thirty-nine paediatric patients were reviewed for anterior cruciate ligament injuries requiring reconstruction at the authors’ institution. Data collected included background information on the injury, including mechanism and age at injury and surgical information including age at surgery, surgical procedure, and technique. Surgical follow-up information was also collected including wound problems, re-ruptures, or growth arrests. The mean age at injury was 14.3 years. The predominant mechanism of injury was twist and turn with 21 reports. The average age at surgery was 15.2 years, with 20 patients undergoing reconstruction of their ACL alone and 19 patients repair of their ACL and menisci. Fourteen patients were treated using the four-strand technique, while 25 patients were treated using the over-the-top method. We have an average follow-up of 1.9 years post-surgery. Three patients in the over-the-top group had wound infections. There were no known growth arrests or re-ruptures in this patient group based on this limited follow-up. Fifty-five percent of patients had meniscal involvement. Those with a meniscal tear were older than those without (14.5 years versus 11.5 years; p< 0.05).

Conclusion: Once rare, injuries of the anterior cruciate ligament in skeletally immature patients have become a common clinical presentation. It is important to have a documentation of the amount of pathologic laxity of the knee joint. Instrumented measurements can show the success of an ACL reconstruction in restoring the patient’s knee to normal joint kinetics.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 320 - 320
1 Sep 2005
Reilly C Tredwell S Mulpuri K Saran N Choit R
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Introduction and Aims: The aims of this study were to assess the clinical and functional outcomes following the treatment of a lumbar Chance fracture and to analyse the spectrum of associated abdominal injuries as seen in the Seat Belt Syndrome.

Method: All patients diagnosed with L1 to L4 Chance fractures at the British Columbia Children’s Hospital were included in this study. Patient data, injuries, treatment and complications were collected from hospital charts. A review of all available spinal radiology including pre-treatment, post-treatment and follow-up x-rays, CTs and MRIs was done to measure pre-treatment, post-treatment and follow-up kyphosis angles, as well as to help classify the Chance fracture. Patients were seen in follow-up to assess for range of motion, tenderness and neurological status. Furthermore, a functional outcome questionnaire by the American Academy of Orthopaedic Surgeons Pediatric Instruments was completed by the patients.

Results: Between December 1984 and February 2001, 27 patients aged three to 17 were treated for lumbar Chance fractures. The mean age at injury was 11.1 years. There were 18 females and nine males. All injuries occurred as a result of a motor vehicle accident. Nineteen were rear-seat passengers and eight were front-seat passengers. Of the 27 patients, 19 were treated surgically. Of these 19, nine were treated with either pedicle screws or laminar hooks and rods, four with intersegmental spinous process (ISP) wires alone, two with sublaminar wires and four with a combination of screws/hooks, rods and ISP wires. One patient had a post-operative urinary tract infection. Of the eight patients treated conservatively, four were treated with a hyperextension cast and four were treated with a hyperextension brace. Neurological impairment was seen in seven of the 19 surgical patients pre-operatively. Post-operatively impairment was impoved in two of the seven patients. One of the eight patients treated conservatively had neurological impairment which spontaneously resolved. A total of 13 patients underwent surgery for an associated abdominal injury. Three cases involved abdominal arterial vascular trauma and 12 involved small bowel injury.

Conclusion: An abdominal and spinal CT must be taken when presented with a Chance fracture with abdominal symptoms. Injury type and kyphosis angle are the main factors that aid in treatment planning in paediatric lumbar chance fractures. A purely soft-tissue injury or a kyphosis angle greater than 20 requires surgical intervention.