Purpose of the study: The issue of which graft to choose for anterior cruciate ligament (ACL) reconstruction is still a matter of debate. An analysis of the literature reveals the difficulty encountered when performing comparative trials. It is also difficult to demonstrate significant differences with results obtained with an insufficient number of patients. We propose here a meta-analysis in order to combine the results obtained with different comparative studies.

Material and methods: The literature search (Medline 1990–2005) was based on the following selection criteria: ACL reconstruction, patellar tendon (PT), gracilis and semitendinous (four-strand hamstring) reconstruction and comparative prospective study. Studies were retained with: > 30 patients per group, minimum follow-up 24 months, IKDC score. Evaluation criteria retained were: anterior pain, resumed activity, IKDC score, differential laxity. The relative risk (RR) statistical method with 95% confidence interval (CI) was applied. Means were calculated and the chi-square and z-tests were applied.

Results: Thirteen studies satisfied our inclusion criteria. These studies had included more than 1300 transplants. Mean rate of anterior pain was 23.2% with PR and 17.3% with hamstring reconstructions. The RR was 0.73 with a CI different from 1. The difference was significant. Resumption of sports activities at the same level, subjective assessment, number of failures, and overall IKDC score were not statistically different between the two types of transplants. The IKDC laxity score was not different but the residual maximal manual differential laxity was greater in the hamstring patients than in the patellar patients in 80% of the cases.

Conclusion: At the observed follow-up, free grafting with a four-strand hamstring tendon or a patellar tendon is an effective method for reconstruction of the ACL. Anterior pain is more frequent with the patellar tendon method and residual laxity is greater with the hamstring method. The long-term outcome will determine whether the residual laxity observed with the hamstring graft has a deleterious effect on the meniscocartilaginous structures. This criteria would minimize the advantage of this technique over the patellar tendon technique concerning the initial anterior pain.