Summary

The dGEMRIC index correlates more strongly with the pattern of radiographic joint space narrowing in hip osteoarthritis at five year follow-up than morphological measurements of the proximal femur. It therefore offers potential to refine predictive models of hip osteoarthritis progression.

Metal-on-metal resurfacing offers an alternative strategy to hip replacement in the young active patient with severe osteoarthritis of the hip. The aim of this study was to compare functional outcomes, failure rates and impending revisions in hybrid total hip arthroplasties (THAs) and Birmingham Hip Resurfacings (BHRs) in young active patients.

We compared the 5-7 year clinical and radiological results of the metal-on-metal BHR with hybrid THA in two groups of 54 hips each, matched for sex, age, body mass index and activity. Function was excellent in both groups as measured by the Oxford hip score (median 13 in the BHRs and 14 in the THAs, p=0.14), but the resurfacings had higher UCLA activity scores (median 9 v 7, p=0.001) and better EuroQol quality of life scores (0.90 v 0.78, p=0.003). The THAs had a revision or intention to revise rate of 8% and the BHRs 6%. Both groups demonstrated impending failure on surrogate end-points. 12% of THAs had polyethylene wear and osteolysis under observation, and there was femoral component migration in 8% of resurfacings. Polyethylene wear was present in 48% of hybrid hips without osteolysis. Of the femoral components in the resurfacing group which had not migrated, 66% had radiological changes of unknown significance (classification proposed).

In conclusion, the early to mid-term results of resurfacing with the BHR appear at least as good as those of hybrid THA. Only by longer term follow-up will we establish whether the change of practice recorded here represents a true advance.

Introduction: We compared the eight- to ten-year clinical and radiological results of the metal-on-metal Birmingham hip resurfacing (BHR) with a hybrid total hip arthroplasty (HYBRID) in two groups of 54 hips, previously matched for gender, age, body mass index and activity level.

Method: Patients were followed up in outpatients and function assessed by using the Oxford Hip Score, UCLA activity score and Euroqol score. Radiographs were assessed for osteolysis and wear. BHR were also assessed for the presence of a pedestal sign around the femoral component.

Results: The mean follow up of the BHR group was 9 years (8.17 to 10.33) and for hybrids 10 (7.53 to 14.5). Four patients had died in the hybrid group and one in the BHR. Four were lost to follow up in each group. The revision rate in the BHR group was 9.25% verses 18% in the Hybrid, a further eight patients in the hybrid group have evidence of wear and osteolysis and are intended for revision (p=0.008). One patient in the BHR group was explored for late onset sciatic nerve palsy. All patients in the hybrid group had evidence of polyethylene wear, mean 1.24mm (0.06–3.03). 90% of the BHR group had evidence of a pedestal sign.

Satisfactory function was shown in both groups. There was no significant difference between groups with respect to the OHS but the UCLA score was superior in the BHR group (p=0.008). There was no significant difference for Euroqol visual analogue score. 56% of hybrids were delighted with their hip replacement verses 65% of BHR patients.

Discussion: After ten years the hip resurfacing patients were still more active and had a lower revision burden than the hybrid hip replacements. Both groups showed worrying radiological evidence of change with long-term follow-up.

Introduction: Femoroacetabular impingement (FAI) is an important cause of hip pain in young adults and a precursor to osteoarthritis. Morphological abnormality of either the acetabulum, proximal femur, or both, may result in FAI. The majority of patients however, have a cam deformity of the proximal femur. From a research perspective, FAI is an example of how subtle morphological abnormality results in a predictable pattern of cartilage damage, and thereby offers great potential as a model to study early degenerative disease and for clinical trials of joint preserving treatments. Accurate classification of the morphology of the hip is essential for this further study.

The aim of this study was to define normal, borderline, and abnormal parameters for the morphology of the proximal femur, in the context of the cam deformity, by studying asymptomatic individuals with normal clinical examination and no osteoarthritis from the general population.

Methods: 157 individuals (79 male, 78 female, mean age 46 years) with no previous history of hip problems were recruited. The participants were the spouses/partners of patients involved in a cohort study of osteoarthritis and FAI. All participants underwent clinical (interview, examination, and hip scores) and radiological assessment (standardised AP Pelvic and cross-table lateral radiographs of each hip). Radiographs were scored for the presence of osteoarthritis, and the morphology of the proximal femur was analysed. The alpha angle, anterior offset ratio, presence of a cam ‘bump’, synovial herniation pit were recorded in each hip.

Results: 21 subjects were excluded because they either had positive clinical features or radiological evidence of osteoarthritis (equivalent to a Kellgren and Lawrence grade of 2). From the remaining 136 subjects, with essentially ‘normal hips from the general population’, mean values for the alpha angle and anterior offset ratio were generated. Borderline and Abnormal values are suggested. Gender differences were noted with higher mean alpha angles and lower offset ratios occurring in men.

Discussion: Although it has limitations, standardised plain radiography remains the cheapest and most convenient way to screen an individual for the presence of a cam deformity. Despite the recent interest in FAI, our knowledge of what is normal in the general population, as assessed using appropriate radiographic techniques, is modest. The ranges provided by this study will facilitate the accurate classification of subjects with FAI, thereby providing guidance for surgeons treating such patients, and also enable the generation of refined cohorts for the study of the natural history of subtle morphological abnormalities of the hip, and for enrolment in clinical trials.

Introduction: Femoroacetabular impingement (FAI) is an important cause of hip pain in young adults and a precursor to osteoarthritis. Genetic factors are important in the aetiology of osteoarthritis of the hip. From a research perspective, FAI is an example of how subtle morphological abnormality results in a predictable pattern of cartilage damage, and thereby offers great potential as a model to study early degenerative disease.

Although many causes of FAI are described, the vast majority of patients give no history of previous hip disease. The purpose of this study was to investigate the extent to which FAI has an underlying genetic basis, by studying the siblings of patients undergoing surgery for FAI and comparing them with controls.

Methods: 66 patients (probands, 29 male, 37 female, mean age 39.1 years) treated surgically for FAI provided siblings for the study. These patients were classified as having cam, pincer or mixed FAI. 101 siblings (55 male, 56 female, mean age 38.2 years) were recruited. The control group consisted of the 77 partners of those siblings (40 male, 37 female, mean age 41.9 years). All subjects underwent clinical (interview, examination, and hip scores) and radiological assessment (standardised AP Pelvic and cross-table lateral radiographs of each hip). Radiographs were scored for the presence of osteoarthritis, and cam- and pincer-type abnormalities.

Results: Participants were classified as a) Normal morphology with no clinical features, b) Abnormal morphology but no clinical features c) Abnormal morphology with clinical signs but no symptoms, and d) Abnormal morphology with symptoms and signs. The sibling relative risks were significant for groups b, c, and d, supporting the hypothesis of an underlying genetic predisposition to FAI. Siblings usually demonstrated the same type of abnormal morphology as the proband. Gender specificity was apparent however, with pincer abnormalities which were usually apparent in female probands being common in sisters but less common in brothers. The brothers of probands with cam deformities almost universally demonstrated the same deformity, although only 50% of sisters did so.

Discussion: Genetic influences are important in the aetiology of FAI. Whether the morphological abnormality is determined at conception or by an inherited predisposition to an acquired event during maturity warrants further study. We have identified a spectrum of disease with a proportion of siblings with abnormal morphology currently asymptomatic. These cohorts present an opportunity to prospectively study the natural history of the condition, improve our understanding of the mechanisms and pathology in early degenerative disease, and potentially to be recruited into clinical trials of surgical and adjuvant treatments.

Introduction: Subtle deformity of the hip joint may cause osteoarthritis. In femoroacetabular impingement (FAI), cam deformities damage acetabular cartilage. Whether surgical removal of cam lesions halts progression is unknown. Sensitive, non-invasive assays of chondral damage are required to evaluate early treatment efficacy.

Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) permits inference of glycosaminoglycan (GAG) distribution. We aimed to determine whether hips with cam deformities have altered GAG content, using dGEMRIC.

Methods: Subjects were recruited from a prospective cohort study. All were clinically and radiographically assessed. Hips with a normal joint space width (> 2.5mm) were eligible for dGEMRIC. 32 Hips (18 male, 14 female, mean age 51.7 years, none of whom had been investigated for hip pain) with (n=21) and without (n=11) cam deformities were scanned.

2 regions of interest (ROI) were studied:

acetabular cartilage from 12 to 3 O’Clock (T1-Index-acet).

The average of all pixels within the given ROI defined the T1-index.

For each hip, the ratio of the GAG content T1-Index-acet/T1-Indextotal was calculated. Mean T1-Indexto-tal and T1-Indexacet/T1-Indextotal were compared.

Results: T1-Indextotal were similar (689ms v 700ms, p=0.79) but T1-Indexacet/T1-Indextotal was lower in cam hips (0.93 v 1.01, p=0.017), indicating localised depletion of GAG content. Cam hips with positive clinical signs had lower T1-Indextotal than cam hips without (629ms v 717ms, p=0.055), and non-cam hips (629ms v 722ms, p=0.049).

Discussion: Cam hips have lower GAG content of their anterosuperior acetabular cartilage. dGEMRIC identified more generalised disease in cases with positive clinical findings. Ratios of GAG content for specific ROIs enable mapping of chondral damage. This may aid understanding of early disease mechanisms, track progression, and facilitate assessment of the efficacy of surgical procedures.

Introduction: Femoroacetabular impingement (FAI) causes pain in young adults and osteoarthritis. Genetic factors are important in the aetiology of osteoarthritis. We aimed to investigate the extent to which FAI has an underlying genetic basis, by studying the siblings of patients undergoing surgery for FAI and comparing them with controls.

Methods: 66 patients (probands, 29 male, 37 female, mean age 39.1 years) treated surgically for FAI provided siblings for the study. Probands were classified as having cam, pincer or mixed FAI. 101 siblings (55 male, 56 female, mean age 38.2 years) were recruited. The control group consisted of their 77 partners and was age and gender-matched. All subjects were assessed clinically and radiologically (standardised AP Pelvic and cross-table lateral radiographs of each hip). Radiographs were scored for the presence of osteoarthritis, and morphological abnormalities.

Participants were classified as:

Normal morphology, no clinical features

Results: The sibling relative risks were significant for groups b, c, and d (ranging between 2–5, p< 0.01). Pro-bands and siblings shared the same pattern of abnormal morphology. Gender specificity was apparent: pincer abnormalities common in sisters but not in brothers. The brothers of probands with cam deformities almost universally demonstrated the same deformity, but only 50% of sisters did.

Discussion: Genetic influences are important in the aetiology of FAI. Whether the morphological abnormality is determined at conception or by an inherited predisposition to an acquired event during development warrants further study. Symptoms are variable, indicating a spectrum of disease progression. These cohorts present an opportunity to prospectively study the natural history of the condition, improve understanding of the mechanisms and pathology, and potentially to be recruited into clinical trials.

Metal-on-metal resurfacing offers an alternative strategy to hip replacement in the young active patient with severe osteoarthritis of the hip. The functional outcomes, failure rates and impending revisions in hybrid total hip arthroplasties (THAs) and Birmingham hip resurfacings (BHRs) were compared after 5–7 years. We studied the clinical and radiological results of the BHR with THA in two groups of 54 hips each, matched for sex, age, BMI and activity.

Function was excellent in both groups as measured by the Oxford hip score (median 13 in the BHRs and 14 in the THAs, p=0.14), but the resurfacings had higher UCLA activity scores (median 9 v 7, p=0.001) and better EuroQol quality of life scores (0.90 v 0.78, p=0.003).

The THAs had a revision or intention to revise rate of 8% and the BHRs 6%. Both groups demonstrated impending failure on surrogate end-points. 12% of THAs had polyethylene wear and osteolysis and there was femoral component migration in 8% of resurfacings. Polyethylene wear was present in 48% of hybrid hips without osteolysis. Of the femoral components in the resurfacing group which had not migrated, 66% had radiological changes of unknown significance.

In conclusion, the early to mid-term results of resurfacing with the BHR appear at least as good as those of hybrid THA.

Introduction: The results of metal-on-metal hip resurfacing (MOMHR) from inventing centres show excellent function with low revision rates in the short to intermediate term. This study investigated whether similar results could be achieved in an independent unit.

Methods: All cases of MOMHR were identified since its introduction in our centre in 1999, and cases with less than 18 months follow-up excluded. Outcome was assessed by Oxford Hip Score (OHS), and UCLA activity score. Complications and further surgery was recorded. Pre-, post-op and follow-up radiographs were reviewed.

Results: 358 resurfacings in 315 patients (238 Birmingham hip resurfacings and 120 Cormet 2000, 8 surgeons). 13 (3.6%) revisions: 4 early fractures, 6 osteonecrosis, 1 aseptic femoral loosening, 1 infection, 1 isolated cup revision. 2 died, 16 (4.7%) were lost to follow-up. Outcome was assessed in the remaining 327 hips at a mean 39 months (18–79). Median OHS 13, median UCLA score 8. 89% employed in moderately heavy or heavy occupational work pre-operatively were similarly employed at follow-up.

2 cups had migrated and 6 had lucent lines. 8 femoral components had migrated. 6 had focal osteolysis. 66% of hips had ‘pedestal’ signs around the stem of the femoral component (classification proposed).

Discussion: The functional outcomes achieved in this series match those from inventing centres, but the revision rate was higher. This is partly explained by early fractures which may be associated with poor case selection or technical errors early in a surgeon’s learning curve. Later failures, of which osteonecrosis is of particular interest, also occurred at a higher rate. Migration of the femoral component may represent impending failure and further work is required to define the aetiology and consequences of the pedestal signs noted.

Introduction: Proximal femoral fracture (PFF) is the leading cause of Trauma admission. Deep surgical wound infection occurs in approximately 3% of these patients. The purpose of this study was to assess the cost of deep infection to the patient, in terms of mortality and social consequences, and to the National Health Service, in terms of financial burden.

Methods: 61 consecutive patients (51 females, 10 males) treated for PFF, complicated with deep surgical wound infection over a seven-year period are presented. A control group consisting of 122 patients, without infection, were individually case matched (2:1) for factors that affect outcome after PFF (age, sex, ASA grade, fracture type, operation, and pre-fracture residence, social dependence, and mobility). Outcomes included length of admission (Trauma unit, rehabilitation bed, community hospital), number of operations, antibiotic administration and outpatient treatment, final destination, and mortality at one, three, and six months. A total cost of treatment was obtained from this data and supplied finance department figures.

Results: MRSA was responsible for 31 cases. Infected cases required an average of two wound debridements. 16 patients had a Girdlestones procedure of whom two were subsequently revised to total hip replacement. For all patients, the average Trauma unit admission was 58 days in the infected cases, with a further 40 days spent in rehabilitation or community beds, versus 16 days and 27 days respectively in the controls (p < 0.001). 34% of infected cases died before discharge versus 15% of controls (p = 0.004). For the patients surviving to discharge, the mean total hospital stay was 124 days for the infected cases versus 45 days in the controls (p < 0.001). A higher proportion of the survivors in the control group returned to their original residence compared to the infected survivors (p = 0.002). The mortality rates in the infected group were 15% at 1 month, 31% at 3 months, and 38% at six months, versus 9%, 20%, and 25% respectively in the control group (p = 0.36, 0.12, 0.12). The median cost of treatment per infected case was 23960 versus 7390 per control case.

Conclusions: Deep surgical wound infection after proximal femoral fracture is a devastating complication for both the patient and the NHS. It is associated with a higher in-patient mortality, and fewer survivors return to their pre-fracture residence. Hospital stay is greatly increased and survivors spend 4 months on average in hospital. Additional costs are huge and are incurred at all levels. The extra financial cost of treating a single infected case would fund the treatment of two non-infected cases. These costs should be considered when allocating funds and beds to Trauma services, in addition to ensuring measures known to minimise infection rates are in place.

The purpose of this study was to investigate the role that genetics play in the aetiology and symptomatology of full thickness tears of the rotator cuff.

From a retrospective, cohort study of 205 patients diagnosed with full thickness rotator cuff tears, we determined, using ultrasound, the prevalence of full thickness tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full thickness rotator cuff tear in siblings v controls was 2.42 (p< 0.0001, 95 % CI 1.77 to 3.31). The relative risk of symptomatic full thickness rotator cuff tear in siblings v controls was 4.65 (p< 0.0001, 95 % CI 2.42 to 8.63).

The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full thickness tears of the rotator cuff.

The purpose of this study was to investigate the association of endocrine disease with calcific tendinitis and the effects that such disease has on its natural history.

A retrospective observational cohort study of 102 consecutive patients (125 shoulders) with calcific tendinitis is presented. Seventy-three (71.6 %) female, 29 (28.4 %) male. Compared with population prevalences, significant levels of endocrine disorders were found in our study cohort. Sixty-six patients (81 shoulders, 62 female (93.9 %), 4 male (6.1 %), mean age 50.3 years) with associated endocrine disease were compared with 36 patients (44 shoulders, 11 female (30.6 %), 25 male (69.4 %), mean age 52.4 years) without endocrine disease. The endocrine cohort were significantly younger than the non-endocrine cohort when symptoms started (mean 40.9 years and 46.9 years respectively, p=0.0026), had significantly longer natural histories (mean 79.7 months compared with 47.1 months, p=0.0015) and a significantly higher proportion underwent operative treatment (46.9 % compared with 22.7 %, p=0.0014).

Disorders of thyroid and oestrogen metabolism may contribute to calcific tendinitis aetiology. Classifying calcific tendinitis into Type I idiopathic and Type II secondary or endocrine-related aids prognosis and management.

Between 1972 and 2002 74 patients were treated under the combined care of the orthopaedic oncology service and lymphoma clinic with primary bone lymphoma. We reviewed the seventeen cases affecting the upper limb (23%). Of the seventeen patients nine remain alive. Assessment of the patient’s clinical presentation, histopathological definition, treatment and function outcome was made. The nine survivors were assessed clinically and with the Oxford shoulder score and the Toronto extremity salvage score.

Average time from first presentation to diagnosis was 7 months. All seventeen were diagnosed as a B –cell non-Hodgkin’s lymphoma, fifteen cases were high grade and two cases were low grade. The scapula was involved in six, humerus eight and clavicle three cases. Seven patients sustained pathological fractures three of which were at presentation; of these two were treated surgically. Eight patients have subsequently died of their disease. Functional outcome in surviving patients after medical treatment was very good with average TESS score of 79% (52%–99%) and OSS of 27 (12–52).

The presentation of lymphoma of the shoulder girdle may mimic benign shoulder conditions and lead to a delay in radiological and histopathological diagnosis. Pathological fracture is a common presentation and complication of treatment, however these fractures have a high chance of healing with medical treatment alone. Although shoulder stiffness remains a problem following medical treatment, overall upper limb function is good. There is little evidence that these patients require surgery in the short to medium term.