Clear cell sarcoma (CCS) of soft-tissue is a rare melanocytic subtype of mesenchymal malignancy. The aim of this study was to investigate the clinical and therapeutic factors associated with increased survival, stratified by clinical stage, in order to determine the optimal treatment. The study was a retrospective analysis involving 117 patients with histologically confirmed CCS, between July 2016 and November 2017, who were enrolled in the Bone and Soft Tissue Tumour Registry in Japan.Aims
Methods
There are concerns regarding complications and longevity of total elbow arthroplasty (TEA) in young patients, and the few previous publications are mainly limited to reports on linked elbow devices. We investigated the clinical outcome of unlinked TEA for patients aged less than 50 years with rheumatoid arthritis (RA). We retrospectively reviewed the records of 26 elbows of 21 patients with RA who were aged less than 50 years who underwent primary TEA with an unlinked elbow prosthesis. The mean patient age was 46 years (35 to 49), and the mean follow-up period was 13.6 years (6 to 27). Outcome measures included pain, range of motion, Mayo Elbow Performance Score (MEPS), radiological evaluation for radiolucent line and loosening, complications, and revision surgery with or without implant removal.Aims
Methods
The meniscus is a fibrocartilaginous tissue that plays an important role in controlling the complex biomechanics of the knee. Many histological and mechanical studies about meniscal attachment have been carried out, and medial meniscus (MM) root repair is recommended to prevent subsequent cartilage degeneration following MM posterior root tear. However, there are only few studies about the differences between meniscus root and horn cells. The goal of this study was to clarify the differences between these two cells. Tissue samples were obtained from the medial knee compartments of 10 patients with osteoarthritis who underwent total knee arthroplasty. Morphology, distribution, and proliferation of MM root and horn cells, as well as gene and protein expression levels of Sry-type HMG box (SOX) 9 and type II collagen (COL2A1) were determined after cyclic tensile strain (CTS) treatment. Horn cells had a triangular morphology, whereas root cells were fibroblast-like. The number of horn cells positive for SOX9 and COL2A1 was considerably higher than that of root cells. Although root and horn cells showed similar levels of proliferation after 48, 72, or 96 h of culture, more horn cells than root cells were lost following 2-h CTS (5% and 10% strain). SOX9 and COL2A1 mRNA expression levels were significantly enhanced in horn cells compared with those in root cells after 2- and 4-h CTS (5%) treatment. This study demonstrates that MM root and horn cells have distinct characteristics and show different cellular phenotypes. Our results suggest that physiological tensile strain is important for activating extracellular matrix production in horn cells. Restoring physiological mechanical stress may be useful for promoting healing of the MM posterior horn.
The aim of this study was to report the mid-term clinical outcome
of cemented unlinked J-alumina ceramic elbow (JACE) arthroplasties
when used in patients with rheumatoid arthritis (RA). We retrospectively reviewed 87 elbows, in 75 patients with RA,
which was replaced using a cemented JACE total elbow arthroplasty
(TEA) between August 2003 and December 2012, with a follow-up of
96%. There were 72 women and three men, with a mean age of 62 years
(35 to 79). The mean follow-up was nine years (2 to 14). The clinical condition
of each elbow before and after surgery was assessed using the Mayo
Elbow Performance Index (MEPI, 0 to 100 points). Radiographic loosening
was defined as a progressive radiolucent line of >1 mm that was
completely circumferential around the prosthesis.Aims
Patients and Methods
Injuries of the meniscal attachments can lead to meniscal extrusion. We hypothesized that the extent of lateral meniscal extrusion (LME) was associated with the severity of the lateral meniscus posterior root tear (LMPRT). This study aimed to evaluate the relationship between preoperative LME and arthroscopic findings of LMPRT in knees with anterior cruciate ligament (ACL) injury. Thirty-four knees that had LMPRTs with concomitant ACL injuries on arthroscopy were evaluated. Patients were divided into two groups, partial and complete root tears, via arthroscopic findings at the time of ACL reconstruction. We retrospectively measured preoperative LMEs using magnetic resonance imaging (MRI). Statistical analysis was performed using the Mann-Whitney U-test and Chi-square test.Purpose
Methods
Meniscus repair can restore the function of torn meniscus in anterior cruciate ligament (ACL)-reconstructed knees. However, few reports investigate the relationship between concurrent meniscus repair with ACL reconstruction and postoperative meniscal position. This study aimed to evaluate the size of the medial meniscus in patients who underwent ACL reconstruction and concomitant all-inside medial meniscus repair. This study received the approval of our Institutional Review Board. Twenty patients underwent ACL reconstruction and concurrent medial meniscus repair of a peripheral longitudinal tear using the FasT-Fix meniscal repair device. Medial tibial plateau length (MTPL) and width (MTPW) were determined by radiographic images. We evaluated the Lysholm score, anteroposterior instability (difference in KT-2000 arthrometer measurement), meniscal healing, and magnetic resonance imaging (MRI)-based medial meniscal length (MML) and width (MMW). The healing status of repaired medial meniscus was assessed by 2nd-look arthroscopy.Background
Methods
Hyaluronan (HA) promotes extracellular matrix (ECM) production and inhibits the activity of matrix degrading enzymes in chondrocytes. The meniscus is composed of the avascular inner and vascular outer regions. Inner meniscus cells have a chondrocytic phenotype compared with outer meniscus cells. In this study, we examined the effect of HA on chondrocytic gene expression in human meniscus cells. Human meniscus cells were prepared from macroscopically intact lateral meniscus. Inner and outer meniscus cells were obtained from the inner and outer halves of the meniscus. The proliferative activity of meniscus cells was evaluated by WST-1 assay in the presence or absence of HA (MW = 600–1200 kDa; Seikagaku). Gene expression of SOX9, COL2A1, and COL1A1 was assessed by a quantitative real-time PCR analysis. The effect of HA on the gene expression and cellular proliferation was investigated under the treatment of interleukin (IL)-1α. Meniscal samples perforated by a 2-mm-diameter punch were maintained for 3 weeks in HA-supplemented media. Cultured meniscal samples were evaluated by histological analyses.Background
Methods
CT-based navigation system in total hip arthroplasty (THA) is widely used to achieve accurate implant placement. Now, we developed our own CT-based navigation system originally, and since then we have been conducting various analysis in order to use the system more effectively. We compared the accuracy of registration with this navigation system and land mark matching type navigation system. In this study, we evaluated the influence of the surgical approach to the accuracy of registration. Between June 2015 and February 2016, 28 consecutive uncemented THAs were performed in 26 patients. The preoperative diagnosis was osteoarthritis in 20 hips, osteonecrosis of the femoral hips in 5, and rheumatoid arthritis in 3. The newly developed navigation system was a CT based, surface matching type navigation system. We used newly developed navigation system and commercially available land-mark type CT-based navigation system in the setting of acetabular sockets under the same condition. After we fixed the cementless cup, we measured the cup setting angle of inclination and anteversion on each navigation system. Postoperative assessment was performed using CT one week after the operation, and measured the actual angle of the cup. Approach of operations were performed via posterolateral approach in 14 hips, and Hardinge approach in 14 hips. We calculated the absolute value of the cup angle difference between intra-operative value and post-operative value with each navigation system and compared the accuracy between each navigation system and surgical approach.Introduction
Methods
Few reports were shown about the position of the cup in total hip arthroplasty (THA) with CT-based navigation system. We use minimally invasive surgery (MIS) technique when we perform cementless THA and the correct settings of cups are sometimes difficult in MIS. So we use CT-based navigation system for put implants with correct angles and positions. We evaluated the depth of cup which was shown on intra-operative navigation system. We treated 30 hips in 29 patients (1 male and 28 females) by navigated THA. 21 osteoarthritis hips, 6 rheumatoid arthritis hips and 3 idiopathic osteonecrosis hips were performed THA with VectorVision Hip navigation system (BrainLAB). Implants were AMS HA cups and PerFix stems (Japan Medical Materials, Osaka). Appropriate angles and positions of cups were decided on the 3D model of pelvis before operation. According to the preoperative planning, we put the implants with navigation system. We correct the pelvic inclination angle and measured the depth of cups with 3D template software.Objectives
Materials and Methods
CT-based navigation system in total hip arthroplasty(THA) is widely used to achieve accurate implant placement. However, its internal structure was a trade secret. Therefore, it was hard to analyze optimal reference points. Now, we developed our own CT-based navigation system originally, and since then we have been conducting various analyses in order to use the system more effectively. The purpose of this study was to analyze the optimal area and the number of registration points, which enables to move initial errors into the acceptable range. We set the anterior pelvic plane(APP) as the reference plane, and defined the coordinates as follows: X-axis for external direction, Y-axis for anterior direction, and Z-axis for proximal direction. We made pelvic bone models after THA, a normal shape and acetabular dysplasia model, and performed registration using an originally developed CT based navigation system. At first, we registered point paired matching at 4 points, and surface matching was performed at 53 points, which were placed around the acetabulum. 20 points were on anterosuperior, 10 points were on posterosuperior, 20 points were on posterior around the acetabulum, and 3 points were on the pubis. We selected surface matching points based on the actual operation approach, calculated the accuracy of the error correction, and searched the optimal area and the number of surface matching points.Object
Methods
We treated 60 hips in 60 patients (8 males and 52 females) with cementless THA that were performed from January 2007 to December 2009 in our hospital. 48 osteoarthritis hips, 5 rheumatoid arthritis hips and 7 idiopathic osteonecrosis hips were included. All patients were performed THA with VectorVision Hip navigation system (BrainLAB, Feldkirchen, Germany). We used AMS HA cups and PerFix stems (KYOCERA Medical co., Osaka, Japan). The mean age of surgery was 61 years old (35–79 years old). The pelvic inclination angles (PIA) were measured with anteroposterior radiographic image in accordance with the Doiguchi's method. The amount of change of the pelvic inclination angle between supine and standing position was 0.6 degrees prior to surgery, 0.7 degree at 1 year after surgery and 2.4 degrees at 5 years after surgery. 7 patients prior to surgery, 7 patient at 1 year after surgery and 18 patient at 5 year after surgery changed more than 5 degrees between supine and standing position. The pelvic inclination angles of 23 patients prior to surgery, 19 patients at 1 year after surgery and 35 patients at 5 years after surgery changed in the retroverted direction with posture change. It tended to increase after surgery.Materials and Methods
Results
CT-based navigation system in total hip arthroplasty(THA) is widely used to achieve accurate implant placement. The purpose of this study was to evaluate the influence of initial error correction according to the differences in the shape of the acetabulum, and correction accuracy associated with operation approach after localization of registration points at anterior or posterior area of the acetabulum. We set the anterior pelvic plane(APP) as the reference plane, and defined the coordinates as follows: X-axis for external direction, Y-axis for anterior direction, and Z-axis for proximal direction. APP is defined by the anterior superior iliac spines and anterior border of the pubic symphysis. We made a bone model of bilateral acetabular dysplasia of the hip, after rotational acetabulum osteotomy(RAO) on one side, and performed registration using infrared-reflective markers. At first, we registered the initial error on navigation system, and calculated the accuracy of the error correction based on each shape of the acetabulum as we increased the surface matching points. Based on the actual operation approach, we also examined the accuracy of the error correction when concentrating the matching points in anterior or posterior areas of the acetabulum.Background
Methods
The shape of proximal femur is important for the selection of implant in total hip arthroplasty (THA). There are few reports about the shape of proximal femur. We analyzed preoperative and postoperative conditions of the proximal femurs of patients before and after total hip arthroplasty with computed tomography (CT) and evaluated the compatibility to the cementless stem. We analyzed 65 hips of 63 patients (10 males and 53 females) who had THA between January 2008 and December 2010 in our hospital. We approximated the center of the femoral head as the center of the inscribed sphere in the femoral head. We defined the axis of proximal femur with the line between the centers of the circles located at 45 mm distal from lesser trochanter (LT) and at 90 mm proximal from LT. We measured the neck-shaft angle of femur, offset of femoral head, and diameter of bone-marrow cavity. After operation, we measured the distance between the stem surface and the edge of the femoral cortex (SF) at 10 mm proximal from LT to evaluate the compatibility of CT. We used PerFix HA cementless stem (Kyocera medical co., Osaka).Objectives
Materials and Methods
The setting angle of the cup is important for achieving the stability and avoiding the dislocation after total hip arthroplasty (THA). It is difficult to set the cup at correct angle in minimally invasive THA by modified Watson-Jones approach. So we use CT-based navigation system. We evaluated the accuracy of with post-operative CT data. We treated 30 hips in 30 patients (7 male and 23 females) by navigated THA. 26 osteoarthritis hips, 2 rheumatoid arthritis hips and 2 idiopathic osteonecrosis hips were performed THA with VectorVision Hip 3.5.2 navigation system (BrainLAB). Implants were AMS HA cups and PerFix stems (Kyocera Medical, Osaka). Appropriate angles and positions of cups were decided on the 3D model of hip joint before operation. According to the preoperative planning, we put the cups with navigation system and stems without navigation system. We measured the anteversion angle with post-operative CT data and 3-dimensional template software.Objectives
Materials and Methods
Proximal humeral shaft fractures are rare injury. In such case, to the best of our knowledge, the treatment by both double-plate method and the MIPO has never been seen before in the literature. Here we report our experience and management about this method. A 69-year-old man who suffered falling down at home to his right shoulder that resulted in co-existing fractures of the proximal humerus and humeral shaft. According to AO/ASIF classification, he had 11-B1 and 12-A1 fractures ipsilaterally. He was treated by double plate method with PHILOS (SYNTHES, Japan) to proximal humerus and narrow LC-LCP(SYNTHES, Japan) to humeral shaft. Intraoperatively we put the skin incision about 3.0 cm each in three places, for reduction and fixation by the MIPO. Postoperatively, external fixation was only sling and physiotherapy was initiated after third post-operative days for range of motion exercises.Introduction
Materials & Methods
In Japan, edoxaban has been used for the prevention of venous thromboembolism (VTE) after total knee arthroplasty (TKA) since June 2011. Edoxaban is an oral direct factor Xa inhibitor, expected to be more convenient for the postoperative treatment of TKA. Enoxaparin, a II and Xa inhibitor, was approved in Japan for the prevention of VTE in patients undergoing orthopedics surgery from 2008. In this study, the effect for the prevention of VTE after TKA was compared between these two drugs in Japanese patients. We studied 42 Japanese patients who underwent TKA from May 2011 to April 2012. The operations were performed under general anesthesia, continuous femoral nerve block, an air tourniquet, and using cements for implant fixation. These patients were divided in two groups, use of 30 mg edoxaban once daily (ED group), and use of 1000 IU of enoxaparin twice daily (EN group). The initial dose was administered between 12 and 21 hours after surgery. We compared the incidence of VTE, bleeding complications, D dimer levels, and hemoglobin (Hb) loss. The screening of VTE was performed by enhanced CT scan screening from the chest to the foot on postoperative day 5 or 6 in all patients. The bleeding complication was divided into major bleeding and minor bleeding with Japanese guideline for the prevention of VTE. D dimer levels and Hb levels were preoperatively and postoperative day 1, 3, 5, 7, and 14. The loss of Hb was calculated from preoperative Hb level minus lowest postoperative Hb level.Introduction
Patients and Methods
The anteversion angle of the cup is important for achieving the stability and avoiding the dislocation after total hip arthroplasty (THA). We place the component considering with the change of inclination of pelvis with its posture change. We analyzed the perioperative pelvic inclination angles with posture change and the time course. We treated 40 hips in 40 patients (9 males and 31 females) with cementless THA that were performed from January 2007 to December 2008 in our hospital. 30 osteoarthritis hips, 3 rheumatoid arthritis hips and 7 idiopathic osteonecrosis hips were included. All patients were performed THA with VectorVision Hip 2.5.1 navigation system (BrainLAB, Feldkirchen, Germany). We used AMS HA cups and PerFix stems (KYOCERA Medical co., Osaka, Japan). The mean age of surgery was 59 years old (35–79 years old). The pelvic inclination angles (PIA) were measured with anteroposterior radiographic image in accordance with the Doiguchi's method.Objectives
Materials and Methods
Computer navigation system has been reported as a useful tool to obtain the proper alignment of lower leg and precise implantation in TKA. This system alsoãζζhas shown the accurate gap balancing which was lead to implants longevity and optimal knee function. The aim of this study was determine that the postoperative acquired deep knee flexion would be influenced by intraoperative kinematics on navigated TKA even under anesthesia. Forty knees from 40 patients, who underwent primary TKA (P.F.C. sigma RPF, DePuy Orhopaedic International, Leed, UK) with computer-navigation system (Ci Knee, BrainLAB / DePuy Inc, Leeds, UK), were recruited in this study. These patients were classified into two groups according to the recorded value of maximum knee flexion at three month after surgery: 15 patients who obtained more than 130 degrees of flexion in Group A, and 25 patients less than 130 degrees in Group B. We retrospectively reviewed about intraoperative kinematics in each group, to obtain the clue for post operative deep-flexion. The measurements of intraoperative kinematics were consisted of 3 points: femoral rotation angle (degree) and antero-posterior translation (mm), which were measured as the translation of the lowest points of femoral component to tibial cutting surface, and the joint gap difference between the medial and lateral components gap (mm). All joint kinematic data were recorded at every 10 degrees of flexion from maximum extension to flexion under anesthesia.Purpose
Materials & methods
CentPillar GB HA stem (stryker®) is developed as the stem fitting the Japanese femur, and now there is CentPillar TMZF HA stem (stryker®) as the improvement type of the stem by coating the PureFix HA with plasma spray. We observed the factors which influenced on the stem subsidence between the two-type stems. We intended for 26 hips 23 patients that we performed total hip arthroplasty (THA) during the period between January 2005 and June 2009 and were able to follow up more than three years. 10 males 11 hips and 13 females 15 hips, the mean age at the time of surgery was 56.5 (range, 29–74) years old, and primary diseases were osteoarthritis (OA) in 17 hips, Idiopathic Osteonecrosis of Femoral Head (ION) in six hips, and rheumatoid arthritis (RA) in three hips. 16 hips were treated with the CentPillar GB HA stem (G group), and 10 hips were performed with the CentPillar TMZF HA stem (T group). The examination items are the stem size, the canal fill ratio of the stem (the top of lesser trochanter, the bottom of lesser trochanter, the distal portion of the stem) and the stem alignment (on anteroposterior radiograph and Lauenstein view).Purpose
Materials and Methods
Accolade TMZF® has the wedged taper shape and is fixed at the middle part. We testified the short term result of Accolade® and investigated the factor of subsidence. We treated 21 hips in 20 patients (6 males and 15 females) with Accolade stem. The mean age was 61.2 years old (40–79 years old). The mean follow-up period was 11.1 months (6–23 months), and those within 5 months after operation were excluded. We measured the width of the stem and the canal of femur at the level of the upper and the lower end of lesser trochanter, and 1 cm above the tip of the stem at operation and at the last follow-up, then calculated the canal fill ratios. We also measured the distance between the tip of the stem and the proximal end of greater trochanter, then calibrated it by directly sizing the acetabular component. The value that subtracted the distance at the last follow-up from the distance at operation meant subsidence. We performed multiple regression study about weight and the canal fill ratio of stem at the level of lower end of lesser trochanter.Purpose
Materials and Methods
