Implantation of ultra-purified alginate (UPAL) gel is safe and effective in animal osteochondral defect models. This study aimed to examine the applicability of UPAL gel implantation to acellular therapy in humans with cartilage injury. A total of 12 patients (12 knees) with symptomatic, post-traumatic, full-thickness cartilage lesions (1.0 to 4.0 cm2) were included in this study. UPAL gel was implanted into chondral defects after performing bone marrow stimulation technique, and assessed for up to three years postoperatively. The primary outcomes were the feasibility and safety of the procedure. The secondary outcomes were self-assessed clinical scores, arthroscopic scores, tissue biopsies, and MRI-based estimations.Aims
Methods
Patellofemoral (PF) complications are among the most frequently observed adverse events after total knee arthroplasty (TKA). It has been reported that PF complications after TKA include decreasing knee range of motion, anterior knee pain, quadriceps and patellar-tendon rupture, patellar subluxation, and partial abrasion and loosening of the patellar component. Although recent improvements in surgical technique and prosthetic design have decreased these complications, the percentage of patients who have a revision TKA for PF complications still ranged up to 6.6% to 12%. For the present study, we hypothesized that the alignment of the femoral component is correlated with PF contact stress. The purpose of this study was to investigate the relationship between femoral component alignment and PF contact stress in vivo, using a pressure sensor in patients who had favorable extension-flexion gap balance during TKA. Thirty knees with medial compartment osteoarthritis that underwent posterior stabilized mobile-bearing TKA using identical prostheses (PFC Sigma RPF; Depuy, Warsaw, IN, USA) by a single surgeon (TM) with modified gap technique under a computed tomography (CT)-based navigation system (Vector Vision 1.61; Brain Lab, Heimstetten, Germany) were evaluated. PF contact stress was measured intraoperatively and compared with the alignment of the femoral component including intraoperative navigation data concerning medial shift of the patella and lateral tilt of the patella, postoperative coronal femoral component angle (alpha angle), postoperative sagittal femoral component angle (gamma angle), postoperative condylar twist angle (CTA), postoperative lateral condylar lift-off angle, and postoperative mechanical femoral component angle (mFCA). In addition, postoperative Insall-Salvati ratio (I-S ratio) was measured by dividing the length of patellar tendon by the greatest diagonal length of the patella.Introduction
Methods
Total knee arthroplasty (TKA) is a well-established procedure associated with excellent clinical results. We have previously reported that intraoperative knee kinematics correlate with the clinical outcome in mobile bearing TKA. In addition, the intraoperative knee kinematics pattern does not correlate with the degree of preoperative knee deformity in mobile bearing TKA. However, the relationship among preoperative knee deformity, intraoperative kinematics and clinical outcome in fixed bearing TKA has been unknown. The purpose of this study is to compare the relationship among preoperative knee deformity, knee kinematics after fixed bearing TKA and the clinical outcome including the subjective outcomes evaluated by the new knee society score (KSS). A cross-sectional survey of thirty-five consecutive medial osteoarthritis patients who had a primary TKA using a CT-based navigation system was conducted. All knees had a Kellgren-Lawrence grade of 4 in the medial compartment and underwent a primary posterior stabilized TKA (Genesis II, Smith&Nephew) between May 2010 and October 2012. In all cases, a computed tomography-guided navigation system (Brain LAB, Heimstetten, Germany) was used. All surgery was performed by the subvastus approach and modified gap technique. Intraoperative knee kinematics was measured using the navigation system after implantation and closure of the retinaculum and soft tissue except for the skin. Subjects were divided into two groups based on intraoperative kinematic patterns: a medial pivot group (M group, n=19)(Figure 1) and a non-medial pivot group (N group, n=16)(Figure 2). Subjective outcomes with the new KSS and clinical outcomes were evaluated. Statistical analysis to compare the two groups was made using unpaired a Student t test.Introduction
Materials and Methods
The effect of the implant posterior condylar offset has recently generated much enthusiasm among researchers. Some reports were concerned about the relationship between the posterior condylar offset and an extension gap. However, the posterior condylar offset was measured in a flexed knee position or in reference to femoral anatomy alone. Posterior femoral condylar offset relative to the posterior wall of the tibia (posterior offset ratio; POR) is possibly the risk of knee flexion contracture associated with posterior femoral condylar offset after TKA. However, there are no reports concerning the relationship between POR and flexion contracture in vivo. The aim of this study is to evaluate the relationship between the measurement of POR and flexion contracture of the knee in vivo. Twenty-seven patients who underwent a primary total knee arthroplasty (PFC Sigma RP-F) were participated in the study. The lateral femoro-tibial angle (lateral FTA) was measured using lateral radiographs obtained by two procedures. Two procedures are applied to obtain true lateral radiographs of the lower extremities. (1) Full-length true lateral radiographs on standing, (2) True lateral radiographs in the prone position (Fig. 1A). ‘Posterior offset ratio’ was defined as Fig. 1B. Significant differences among groups were assessed using two-tailed Student's t-tests. Spearman's correlation analysis was performed to evaluate the relationship between lateral FTA and posterior offset ratio of patients.Introduction
Methods
We have previously reported that patients who demonstrated medial pivot kinematics pattern after total knee arthroplasty (TKA) had better clinical results than that of non-medial pivot pattern. However, it is unclear how preoperative kinematics pattern affects postoperative knee kinematics. The aim of this study was to evaluate the relationship between preoperative and postoperative knee kinematics pattern in TKA. The present study consists of 38 patients with medial osteoarthritis who underwent a primary TKA using a CT-based navigation system from July 2010 to September 2012. All the operations were performed by a single surgeon using a subvastus approach and the same posterior cruciate ligament substituting type (PS type) of prosthesis (Genesis II™ total knee system, Smith & Nephew, Memphis, TN). The proximal tibia osteotomy and the distal femur osteotomy were set on the navigation system perpendicular to the mechanical axis in the coronal plane with 3° tibial posterior inclination in the sagittal plane. The coronal plane ligament imbalance was corrected until the gap imbalance was fewer than 2 mm. This gap balance was checked using a ligament balancer (Smith & Nephew) at 80 N in medial and lateral compartment of the knee. The navigation system was used to measure the flexion gap with the CAS ligament balancer (Depuy, Warsaw, IN, USA) at 90° knee flexion. The amount of external rotation on femoral osteotomy was adjusted by the navigation system with a balanced gap technique. The patella was resurfaced and a lateral release was not performed. Tibial A-P axis of the tibial tray was placed parallel to Akagi's line. We measured each kinematics pattern immediately after capsule incision (preoperative knee kinematics) and after implantation (postoperative knee kinematics) in TKA. Subjects were divided into two groups based on kinematics patterns: a medial pivot group (group M) and a non-medial pivot group (group N). A chi-square test was used for statistical analysis. P values less than 0.05 were considered significant.Introduction
Materials and Methods
The deletion of gangliosides enhanced OA development by elevating MMP-13 and ADAMTS-5 expression and accelerating chondrocyte apoptosis. Gangliosides possibly play suppressive roles in IL-1α-induced inflammatory signaling cascades. We have previously reported that glycosphingolipids (GSLs) play chondroprotective roles in the cartilage degradation process [1]. Gangliosides, one of the series of GSLs, are known to be important in intercellular signal transduction and cell-to-cell recognition [2]. Therefore, we hypothesised that gangliosides are important in cartilage metabolisms among the GSLs species. The purpose of this study was to determine the functional role of gangliosides in the development of OA in murine models.Summary Statement
Introduction
