header advert
Results 1 - 6 of 6
Results per page:
Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_14 | Pages 45 - 45
1 Dec 2019
Huard M Detrembleur C Poilvache H van Cauter M Driesen R Yombi J Neyt J Cornu O
Full Access

Aim

Apart from other biomarkers isolated in the synovial fluid, alpha-defensin appears to be a promising diagnostic tool to confirm a periprosthetic joint infection (PJI) in the hip or knee. The purpose of this study was to evaluate the sensitivity and specificity of an alpha defensin lateral flow (ADLF) test compared to usual standard classifications in the diagnostic management of PJI.

Method

This investigation was set up as a multicenter prospective cohort study. Synovial fluid was obtained by means of joint aspiration or intra-operative tissue biopsies. A presumptive PJI diagnosis was made according to criteria outlined by the Musculoskeletal Infection Society (MSIS), the Infectious Diseases Society of America (IDSA) and the European Bone and Joint Infection Society (EBJIS). The intention to treat by the surgeon was logged. Sensibility and specificity for the ADLF test was plotted for each aforementioned diagnostic algorithm. Spearman correlations between all scores were analyzed. Multiple logistic regression was used to determine the contribution of independent variables to the probability of PJI.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_14 | Pages 47 - 47
1 Dec 2019
Vermuyten L McPherson EJ Neyt J
Full Access

Aim

At present, a variety of clinical guidelines for treatment of periprosthetic joint infections (PJI) inevitably lead to a variety in outcomes by differing case management. Ideally a treatment algorithm should incorporate all components contributing to the decision-making process for a patient tailored solution in PJI. We aim to present a comprehensive and reproducible treatment algorithm based on a validated staging system, a thorough understanding of the host, the causative microbiome and implant complexity.

Method

The diagnosis of a PJI was defined according to major and minor criteria following revised International Consensus Symposium algorithm

The validated McPherson staging system was used in our university hospital from January 2015 until January 2019 in referred PJI patients. Standardised preoperative and postoperative survey documents were completed in order to register data from the patient's medical, social and surgical history. The complexity of the infected implant was taken into consideration, including quantity of preceding procedures, residual bone stock, type of fixation, magnitude of prosthetic components and presence or absence of reconstructive options. Further, preoperatively obtained bacteriological information by means of arthrocentesis or tissue/bone biopsies was categorized according to the mono- or polybacterial nature and to the qualification of virulence and difficulties to treat. Social and professional history, financial impediments and patient's functional outcome wishes were included in the joint decision making.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_22 | Pages 87 - 87
1 Dec 2017
Stragier B Renard A Vanlaer L Verhaegen J Neyt J
Full Access

Aim

The purpose of this single center study was to analyze the robustness and thoroughness of debridement and irrigation in first stage procedures for periprosthetic joint infections in which the latter had been confirmed by fulfilling the PJI criteria produced by the musculoskeletal infection society.

Method

After introduction of ‘a clean phase’ concept in our center, we developed a method of using new instrumentation sets and waterproof cover sheets as well as sets of gloves and aprons after thorough debridement followed by copious irrigation under a splash sheet, once the prosthetic components were removed during which several (6 to 8) tissue biopsies and cultures were harvested. ‘Clean phase’ tissue specimens ad random were again obtained and cultured and compared with ‘dirty phase’ cultures and sonication results. Our zero hypothesis was that we were not able to entirely eradicate bacterial colonization. We tested this hypothesis during a period of 18 months in a consecutive series of first stage revisions for PJI at our center after introduction of the clean phase concept.


The Bone & Joint Journal
Vol. 99-B, Issue 9 | Pages 1176 - 1182
1 Sep 2017
Berger P Van Cauter M Driesen R Neyt J Cornu O Bellemans J

Aims

The purpose of this current multicentre study is to analyse the presence of alpha-defensin proteins in synovial fluid using the Synovasure lateral flow device and to determine its diagnostic reliability and accuracy compared with the prosthetic joint infection (PJI) criteria produced by the Musculoskeletal Infection Society (MSIS).

Patients and Methods

A cohort of 121 patients comprising 85 total knee arthroplasties and 36 total hip arthroplasties was prospectively evaluated between May 2015 and June 2016 in three different orthopaedic centres. The tests were performed on patients with a chronically painful prosthesis undergoing a joint aspiration in a diagnostic pathway or during revision surgery.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_23 | Pages 8 - 8
1 Dec 2016
Declercq P Goris S Neyt J Wauters J Spriet I
Full Access

Aim

Preoperative joint aspiration cultures (PJACs) are of great value in diagnosing prosthetic joint infections (PJIs). Studies investigating the predictive value of PJACs to identify causative pathogens in PJI, which is off course relevant for the correct initiation of antimicrobial treatment, are limited. The objective of this study was to investigate whether the PJACs are in agreement with causative pathogens in PJIs.

Method

A retrospective monocentric study was conducted at the 40-bed orthopedics department of a tertiary centre. Medical files of patients with proven prosthetic knee or hip infection with PJACs from maximum 6 months prior to the first stage of a two-stage revision admitted between March 2010 and December 2014 were evaluated. A proven PJI was defined as at least two positive preoperative or intraoperative cultures, the presence of purulent synovial fluid or purulence at the implant site or surrounding the prosthesis without other identifiable causes, the presence of acute inflammation upon histopathological examination of the periprosthetic tissue at the time of surgery or the presence of a sinus tract communicating with the prosthesis. In order to identify the causative pathogen(s) per patient, a multidisciplinary team, consisting out of a microbiologist, a septic orthopedic surgeon, two infectious diseases specialists and two clinical pharmacists, assessed the relevance of pathogens cultured in the PJACs and intraoperative deep samples based on the current 2012 IDSA guidelines. Per patient, agreement of PJACs corresponding to the retained causative pathogen(s) was investigated in two ways: 1) on species level and 2) on Gram stain or fungi level.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_VI | Pages 4 - 4
1 Mar 2012
Ashby E Katchburian M Paterson M Neyt J Roposch A
Full Access

Purpose

To determine the impact of sonographic information on surgeons' diagnostic thinking and decision-making in the management of infants with clinically suspicious hip dysplasia.

Four experienced consultant surgeons examined 66 hips referred for possible hip dysplasia and reported for each hip (i) the confidence level (visual analogue scale 0-100) about the diagnosis of this hip, and (ii) how they would manage the hip. Each infant was referred to ultrasound and the same surgeon repeated the rating with the sonographic information available. We determined the efficiency in diagnostic thinking and calculated the mean gain in diagnostic confidence that was provided by the sonographic information. We also determined the therapeutic efficacy, ie the impact of ultrasound information on surgeons’ management plans.

The ultrasound led to a change in diagnosis in 34/66 (52%) hips. However, the management plan only changed in 21/66 (32%) hips. The mean gain in reported diagnostic confidence was 19.37 (95% CI = 17.27, 21.47). If the treatment plan did not change, there still was a gain in diagnostic confidence but this gain was small with a mean value of 8 (95% CI = 5.29, 10.70). However, if the ultrasound led to a change of the treatment plan, the mean gain in diagnostic confidence was much higher with 46 (95% CI = 30.53, 60.79). The difference was -37.67 (P < 0.0001). Ultrasound was most useful (mean gain >30) in hips demonstrating limited abduction or a positive Galeazzi sign.

Conclusion

In this study, the sonographic information only led to a modest gain in diagnostic confidence. Ultrasound was particularly helpful for surgeons in clarifying hips with limited abduction or signs of leg length difference.