Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_16 | Pages 33 - 33
1 Apr 2013
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Canonical Wnt inhibitor Sclerostin (SOST) may be a key mechanotransduction regulator. Unloading/loading 10 week old Sost−/− and WT mice. Unloading: Quads and calf muscles injected each with 0.5U botulinum toxin (BTX, Allergan) caused tibial unloading. Loading: 1200 cycles of tibial axial loading, 1200μe on mid-shaft, 4Hz, 5 days/week. Treated and control tibiae μCT scanned (Skyscan 1174) at 2 weeks.Introduction
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