Implant-associated infection remains one of the biggest challenges facing orthopaedics and there is an urgent clinical need to develop new prophylactic strategies. We have previously shown that CSA-90, a broad-spectrum antimicrobial, prevented infection in an infected open fracture model. In this study we developed a novel model of implant-associated infection, in which to further test the potential of CSA-90 as a prophylactic agent. All studies were approved by the local animal ethics committee. 3D-printed porous titanium implants were implanted into the distal femora of 18 week-old male Wistar rats under general anaesthesia. The treatment groups' (n=10) implants were pre-coated with 500μg CSA-90 in saline. Aim
Method
In January 2012, the Department of Health reportedly claimed that data demonstrated ‘half of knee surgery does not substantially change the outcome for patients: their mobility is not improved that much, nor their pain’. Furthermore, in recent years knee replacement surgery has been described as a procedure of limited clinical value (PLCV) by commissioning bodies nationwide. This study aimed to establish whether patients in Reading were satisfied with their surgery at five years and whether there was an objective improvement in their pain and function following surgery. Five-year data was retrospectively reviewed from 130 knee replacements performed between January 2004 and July 2005. Patient details, intra-operative data and patient reported outcome measures (PROMs) were downloaded from our OrthoWave database. The Oxford Knee Score was completed pre-operatively, at six months and then yearly to five years, measuring pain and function specific to the knee operated on. In addition, patients were asked directly whether they felt satisfied with their joint replacement surgery. The sample population consisted of 52 males and 78 females, with a mean age of 70 and mean body mass index of 30.2. Twenty-three of the patients had undergone uni-compartmental surgery (either Oxford or St George), with the remainder having either PFC or Scorpio total knee replacements. The mean pre-operative Oxford Knee Score was 20.4. The mean improvement in scores at six months was 14.77 (95% confidence interval 13.25–16.28, p<0.0001) and 17.23 at five years (95% confidence interval 15.66–18.79, p<0.0001). On direct questioning, 85.6% of patients were satisfied with their knee replacement, 3.4% were dissatisfied and 10.9% remained unsure. Reasons identified for dissatisfaction included chronic pain syndromes and the need for early revision surgery. Patient reported outcome measures are increasingly being used to justify outcomes of surgery and the Oxford Knee Score is particularly helpful as it relates function and pain to the knee operated on, whilst attempting to minimise the effect of confounding co-pathology. This five-year data suggests that the majority of patients are satisfied with their knee surgery. A significant improvement in pain and function is evident at six months post-operatively and continues to be demonstrable at five years, supporting the British Orthopaedic Association's strong rebuttal of the recent negative press regarding knee surgery.
