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Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_23 | Pages 52 - 52
1 Dec 2016
McBride S Mowbray J Caughey W Wong E Luey C Siddiqui A Alexander Z Playle V Askelund T Hopkins C Quek N Ross K Holland D
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Aim

To describe the epidemiology, clinical features and outcomes of native joint septic arthritis in adults admitted to Middlemore Hospital in Auckland, New Zealand.

Method

Single-centre retrospective cohort study from 2009 to 2014. Patients ≥16 years of age were identified using ICD-10AM coding data. Electronic records were reviewed for demographic, clinical, laboratory, treatment and outcome data. Total and hemi-arthroplasty infections were excluded.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 188 - 188
1 Jul 2014
Zulqadar S McBride S Knothe U Tate MK
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Summary Statement

The purpose of this experimental imaging study is to determine the Poisson's ratio of ovine periosteum, using strain mapping data from an imaging study designed to elucidate the mechanical environment of periosteal progenitor cells in situ during stance shift loading.

Introduction

Periosteum is a composite, so-called “smart” or stimuli responsive material that provides a niche for pluripotent cells that exhibit mechanosensitivity in their proliferative and differentiation behavior. The overarching aim of this research program is to explore, understand, and exploit the mechanical signals that promote cell lineage commitment and de novo bone generation during embryonic development and postnatal healing. Further, our working hypothesis is that periosteum derived progenitor cells are highly sensitive to their local mechanical milieu, which guides their proliferation, motility and differentiation behavior. As a first step toward understand the role of periosteum anisotropy on defining the local mechanical milieu of a given progenitor cell, the objective of the current study is to determine the Poisson's ratio of ovine periosteum and its sensitivity to near, mid- and long-range strains.