dalbavancin, a lipo-glycopeptide antibiotic effective against Gram-positive bacteria (including methicillin-resistant non-interventional, retrospective, single-center pharmacological study. We included adult patients with at least one dalbavancin TDM determination from July 1, 2022 to February 1, 2024 and treated with outpatient parenteral antimicrobial therapy. We recorded dalbavancin trough concentration (Cmin) and its peak concentration (Cmax) and employed log-linear regression models to predict the timing of dalbavancin dosing, aiming to sustain Cmin levels above 4 or 8.04 mg/L, according to recent literature. Data regarding index infections, patients’ characteristics, outcomes, and adverse events were also collected.Aim
Methods
The Authors present a ligament tensor for the evaluation of the ligaments balance used during the implant of total knee prosthesis, which is able to suggest the orientation of the bone resection, not only in knee flexion, but also in extention. This instrument provides for the placement of the endomedullary rod equipped (figures 1 and 2) with a plate of various valgus levels on which, the balancing part of the tensor, is pushing against, while the stable part is leaning against the tibial resected surface (figure 3). This system allows to choose the right valgus level, without having to recur to the ligamentous lysis, if so only minimum, and above all, allows this way to aviod the error of orienting the distal femoral resection due to the imperfect coaxiality between the endomedullary rod and the femoral canal. This mistake might happen because of the imperfect point of entrance and/or because of a not so small difference between the rod caliber and the femoral canal width.
