There are a number of patients in whom hip preservation surgery is not indicated as they have developed signs of early osteoarthritis, and nor can they have a hip replacement as they are too early in the disease process. The use of PRP in OA of the hip has not been studied systematically and this study concisely collates all the available data in the use of PRP in Hip OA. This systematic review and meta-analysis aimed to assess intra-articular platelet-rich plasma as a therapeutic intervention for hip osteoarthritis, including the duration of efficacy, influence of dose and composition of PRP, and the incidence of adverse effects.

We performed literature searches on the MEDLINE, EMBASE, CINHAL, WEB OF SCIENCE, COCHRANE and SCOPUS databases, and PRSIMA guidelines were followed. Data was pooled using random effects meta-analysis. We assessed quality of the included studies using the Methodological Index for Non-Randomised Studies (MINORS) instrument, with an additional assessment for Randomised Controlled Trials with the Revised Cochrane risk-of-bias tool for randomized trials (RoB 2).

Eight studies were included in the analysis, with data from a total of 331 patients. PRP significantly reduced pain compared to baseline at multiple timepoints, with the greatest effect at 1–2mo follow-up. PRP only significantly improved function at the 1–2mo follow-up. A significantly larger reduction in pain was achieved with a single injection or PRP compared to multiple injections, a total injected dose of PRP <15mL compared to ≥15mL or using a leukocyte-poor PRP preparation compared to leukocyte-rich PRP. There were no lasting adverse effects.

Low and moderate quality evidence suggests that PRP reduces pain and improves function at endpoint compared to baseline. Moderate quality evidence suggests a larger reduction in pain is achieved with a single injection of PRP compared to multiple injections, and low quality evidence attributes a larger reduction of pain with a total injected dose of PRP <15mL compared to ≥15mL or using leukocyte-poor PRP compared to leukocyte-rich PRP.

Introduction

Patients with recurrent low back pain (LBP) exhibit changes in postural control. Stereotypical muscle activations resulting from external perturbations include anticipatory (APAs) and compensatory (CPAs) postural adjustments. This study aimed to determine differences in postural control strategies (APAs and CPAs) between those with and without lumbar disc degeneration (LDD) and LBP.

Introduction

The usefulness of markers of non-specific low back pain (NSLBP), including MRI derived measurements of cross-sectional area (CSA) and functional CSA (FCSA, fat free muscle area) of the lumbar musculature, is in doubt. To our knowledge, such markers remain unexplored in Lumbar Disc Degeneration (LDD), which is significantly associated with NSLBP, Modic change and symptom recurrence. This exploratory 3.0-T MRI study addresses this shortfall by comparing asymmetry and composition in asymptomatic older adults with and without Modic change.

Purpose: To correlate arthroscopic appearances of the anterior and posterior meniscofemoral ligaments (aMFL and pMFL respectively) with their appearances on magnetic resonance imaging.

Methods: 50 patients underwent MRI scanning of their knees for a variety of suspected pathologies. The radiological presence or absence of the MFLs was assessed by examination of sequential coronal and sagittal T2 weighted MRI scans. Arthroscopic examination of the knees was subsequently performed, during which the MFLs were identified using several anatomical cues. These included their femoral and meniscal attachments, their obliquity relative to the PCL, and the meniscal “tug test”. Identification was classed as “easy” or “hard” by the operating surgeon.

Results: From 50 knees 44 (88%) aMFLs and 30 (60%) pMFLs were identified on MRI scanning, whilst 47 (94%) aMFLs and 5 (10%) pMFLs were identified arthroscopically. Identification of the presence or absence of the aMFL was classed as easy in 47 (94%), whilst the pMFL was easy to identify in only 5 (10%) of knees, of which 3 (6%) had a ruptured PCL. Using arthroscopy of the aMFL as the gold standard, the sensitivity and specificity of MRI in detecting the aMFL were 94% and 75% respectively. Equivalent values for the pMFL were not calculated due to the difficulty of identifying the pMFL arthroscopically. Thus, with the exception of PCL-deficient knees, it was felt that many pMFLs were missed due to difficulties in identification through anterior portals.

Conclusions: This is the first study correlating the MRI appearances of the MFLs with arthroscopic findings. MRI is relatively sensitive in identifying the aMFL, but its accuracy in identifying the pMFL remains undetermined. Accurate identification of the MFLs at MRI is of value when assessing the status of the PCL, as these ligaments may contribute to stabilising the PCL-deficient knee.