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Bone & Joint 360
Vol. 4, Issue 2 | Pages 35 - 36
1 Apr 2015
Forward DP Lewis CP


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 542 - 542
1 Aug 2008
Lewis CP Clarke HJ Hobbs CM
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Introduction: Intra-articular injection of steroid to the hip prior to joint arthroplasty has been suggested in some studies to carry a risk of infection up to 30% and subsequent revision surgery required in up to 12.5%.

Methods: We undertook a review of all intra-articular hip injections performed at the Queen Alexandra Hospital, Portsmouth and the Royal Haslar Hospital, Ports-mouth between January 2000 and April 2006. Hospital notes including operation notes, anaesthetic preoperative assessments and clinic letters were used to collect the following data. Name, age, sex, and premorbid conditions in particular diabetes, medication, date of injection, substance injected, date of arthroplasty and post operative complications.

Results: 370 intra-articular hip injections were performed of which 55 subsequently had total hip arthroplasty. 1 required washout post operatively but components remained and to date have not required revision. 1 required excision arthroplasty to eradicate deep infection and is still awaiting revision arthroplasty. This shows an infection risk of 3.6% and revision rate of 1.8%.

Discussion: Our review does not show a high rate of infection following intra-articular injection. We conclude that the therapeutic and diagnostic benefits of intra-articular injection may be considered prior to total joint arthroplasty without the increased risk of subsequent infection


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 6 | Pages 790 - 793
1 Jun 2007
Norrish AR Lewis CP Harrison WJ

Patients infected with HIV presenting with an open fracture of a long bone are difficult to manage. There is an unacceptably high rate of post-operative infection after internal fixation. There are no published data on the use of external fixation in such patients. We compared the rates of pin-track infection in HIV-positive and HIV-negative patients presenting with an open fracture. There were 47 patients with 50 external fixators, 13 of whom were HIV-positive (15 fixators).

There were significantly more pin-track infections requiring pharmaceutical or surgical intervention (Checketts grade 2 or greater) in the HIV-positive group (t-test, p = 0.001). The overall rate of severe pin-track infection in the HIV-positive patients requiring removal of the external-fixator pins was 7%. This contrasts with other published data which have shown higher rates of wound infection if open fractures are treated by internal fixation.

We recommend the use of external fixation for the treatment of open fractures in HIV-positive patients.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_II | Pages 108 - 108
1 Feb 2003
Harrison WJ Lewis CP Lavy CBD
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25 cases of closed fractures around the distal femoral growth plate were analysed prospectively over a one-year period. There were 22 males and 3 females. Mean age was 16 years (range 7 to 22).

According to the classification of Salter and Harris there were 6 cases (24%) of type 1 fracture, 12 (48%) type 2 fractures, 3 (12%) type 3, and 4 (16%) type 4. Mechanism of injury was football in 13 (59%), simple fall in 4 (18%), crush in 2 (9%), RTA in 2 (9%), and fall from height in 1 (5%); in 3, the mechanism was not recorded. The average time from injury to hospital admission was 5 days (range 0 to 17 days).

Management was conservative in 4 and operative in 21. The medial parapatellar approach was used in 16. Post-surgically plaster cylinders were used for a mean of 3 weeks (range 0 to 6 weeks). No patient received physiotherapy.

In the operative cases, sepsis was observed in 1 case (5%). This was a crash injury with a skin ulcer that became septic postoperatively and later required knee fusion.

Of the remaining 20 operative cases, 17 cases were reviewed, 4 to one year, 9 to six months, and 4 to three months. There were no cases of deformity, nor wound complications. Those reviewed at one year had an excellent range of movement averaging 0 to 117 degrees (range 0–100 to 0–140). At six months the average range of movement was 1–98 degrees (range 5–70 to 0–140) and at three months 2–62 degrees (range 10–50 to 0–95).

In conclusion, we believe that these difficult fractures should usually be managed operatively where expertise allows. Preliminary results suggest that the medial parapatellar approach provides excellent access but may inhibit initial rehabilitation.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_II | Pages 103 - 103
1 Feb 2003
Harrison WJ Lewis CP Lavy CBD
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A prospective study was undertaken of wound healing in HIV positive patients undergoing orthopaedic implant surgery. 175 implant operations were assessed. 40 operations (23%) were in HIV positive individuals. Wounds were scored using the Asepsis scoring system.

Closed fractures in HIV positive patients had 1 (3. 5%) major infection. No correlation was seen between CD4 count and risk of wound infection.

With regards to early wound sepsis, implant surgery can be undertaken safely in HIV positive individuals with closed injuries regardless of CD4 count. The risk of wound sepsis rises dramatically in implant surgery for HIV positive patients with open fractures.


The Journal of Bone & Joint Surgery British Volume
Vol. 84-B, Issue 6 | Pages 802 - 806
1 Aug 2002
Harrison WJ Lewis CP Lavy CBD

We performed a prospective, blind, controlled study on wound infection after implant surgery involving 41 procedures in patients infected with the human immunodeficiency virus (HIV) and 141 in HIV-negative patients. The patients were staged clinically and the CD4 cell count determined. Wound infection was assessed using the asepsis wound score. A risk category was allocated to account for presurgical contamination.

In HIV-positive patients, with no preoperative contamination, the incidence of wound infection (3.5%) was comparable with that of the HIV-negative group (5%; p = 0.396). The CD4 cell count did not affect the incidence of infection (r = 0.16). When there was preoperative contamination, the incidence of infection in HIV-positive patients increased markedly (42%) compared with that in HIV-negative patients (11%; p = 0.084).

Our results show that when no contamination has occurred implant surgery may be undertaken safely in HIV-positive patients.


The Journal of Bone & Joint Surgery British Volume
Vol. 84-B, Issue 5 | Pages 732 - 734
1 Jul 2002
Lewis CP Lavy CBD Harrison WJ

The atlas of Greulich and Pyle for skeletal maturity and epiphyseal closure is widely used in many countries to assess skeletal age and to plan orthopaedic surgery. The data used to compile the atlas were collected from institutionalised American children in the 1950s.

In order to determine whether the atlas was relevant to subSaharan Africa, we compared skeletal age, according to the atlas, with chronological age in 139 skeletally immature Malawian children and young adults with an age range from 1 year 11 months to 28 years 5 months. The height and weight of each patient were also measured in order to calculate the body mass index.

The skeletal age of 119 patients (85.6%) was lower than the chronological age. The mean difference was 20.0 ± 24.1 months (t-test, p = 0.0049), and the greatest difference 100 months. The atlas is thus inaccurate for this group of children.

The body mass index in 131 patients was below the normal range of 20 to 25 kg/m2.

The reasons for the low skeletal age in this group of children are discussed. Poor nutrition and chronic diseases such as malaria and diarrhoea which are endemic in Malawi are likely to be contributing factors. We did not find any correlation between the reduction in body mass index in our patients and the degree of retardation of skeletal age.