The purpose was to develop an objective measurement system to assist in the prescription of supportive seating for non-ambulant cerebral palsy children with scoliosis.

Currently the prescription of patient’s bespoke seating setup relies on clinical skills and knowledge of trained seating staff (physiotherapists and engineers). Therefore to develop an objective measurement system to supplement this clinical approach, a user centred design approach was used.

Standard design processes presented in Pahl’s ‘Engineering Design’ (2007) were adopted, allowing in depth user involvement. Stakeholders (clinical, seating, and technical staff) were interviewed to develop requirements lists for each group. Following each development stage; task clarification; concepts; embodiment; detailed design; manufacture; and commissioning, these requirements were reviewed with stakeholders.

Requirements lists were collated to form the device specification, involving all stakeholders allowed the discussion of contradicting requirements. The final design incorporated critical aspects of seating while measuring important outcomes such as force distribution and spinal deformities.

A user centred design approach allowed for informative decision making from stakeholders, highlighting the fundamental requirements and facilitated effective solutions to meet these requirements.

The manufactured device complies with the collaborated specification, utilising stakeholder defined spinal and seating parameters. This was commissioned for use in a pilot study involving twenty non-ambulant cerebral palsy children aged 5–11 years, with high risk of scoliosis.

Ethics approval: Ethics approval granted by Leeds (West) Research Ethics Committee

COREC number: 08/H1307/22

Interest Statement: None

Percutaneous vertebroplasty (PVP) is an emerging interventional technique for treatment of vertebral compression fractures. Bone cement is introduced to mechanically augment fracture and pain relief is almost immediate. Recent clinical and biomechanical studies have outlined the phenomenon of fractures occurring in adjacent vertebrae following PVP [1,2]. It is widely believed that rigid cement augmentation may cause a shift in the normal loading pattern of the spine thereby resulting in adjacent fractures. However, very few studies have attempted to quantify this effect [3].

Most biomechanical studies adopt a single vertebral body as a model for PVP analysis. With this approach it is not possible to determine the effect of load distribution on adjacent structures. Where multi-segment vertebrae have been used there is little documentation of the fracture characteristics produced or their repeatability. The purpose of this study was to develop a 3-vertebra model for the biomechanical analysis of PVP. The particular focus was on developing a robust technique for generating repeatable level of fracture severity from specimen to specimen.

An alignment device was developed to fit into standard materials testing machine, which allowed constant axial compression without causing lateral bending or flexion-extension of the specimen’s ends. Porcine 3-segment specimens (T8-L2) were mechanically compressed to failure at a rate of 5mm/min applied vertically at a distance of 35% to the anterior edge of the specimen’s anterior-posterior length. During the test load-displacement data was displayed in real time on a PC. In order to generate uniform fractures, a protocol was devised in which the specimens were compressed for a further 6mm after initial yield point. After the initial fracture the segments were augmented with 3ml of PMMA cement injected through each pedicle and then recompressed. The fracture characteristics generated under these conditions were analysed using quantitative microcomputer tomogragy (μCT).

μCT images showed that fractures were generated in the central vertebra, with some propagation towards adjacent vertebra. The results support the use of a 3-segment specimen as a better representation for PVP analysis. The method will enables the load shift and fracture progression on either side of the augmented vertebra to be observed, thereby providing a more complete picture of load-bearing kinetics. Secondly, the middle, augmented motion segment remains unconstrained by platens and cement impressions; hence its anatomical boundary conditions are less compromised. Although longer segments have been shown to be more anatomically appropriate, it is difficult to apply physiologic levels of load without causing the specimen to buckle. We were able to minimise buckling effect by incorporating an alignment device to position the specimen without constraint. Given the preceding observations, the concepts of 3-segment specimen in PVP biomechanical tests provides a suitable compromise in choosing an appropriate clinical setting for in-vitro testing of biological spine specimens.

Introduction: Aseptic loosening is a long-term complication of many cemented arthroplasty procedures. The integrity of the fixation interface, in particular the level of interdigitation between cement and bone, is crucial to sustaining the stability of arthroplasty components[1]. Studies have shown that the viscosity of cement at the time of application is a significant parameter in determining this level of interdigitation[2]. However, the rheological properties of cement at key stages in arthroplasty procedures have not been quantified, and it is unclear if current operative techniques achieve optimum cement delivery properties. Furthermore, because the cure process of bone cement is highly dependent on environmental conditions, it is extremely difficult to accurately predict the time to curing. Oscillatory shear rheometry can be used to characterise the viscoelastic properties of bone cement. However, most commercial rheometers used for this purpose are too large, expensive and delicate for peri-operative use. The aim of this work is to develop a new laboratory method for measuring the viscoelastic properties of bone cement at the time of application and to investigate the relationship between these properties and the level of cement interdigitation.

Methods: A simple, inexpensive electromagnetic rotary actuator has been developed to provide accurate measurements of force, displacement and velocity without the use of sensors. These parameters can be used to continually monitor both viscous and elastic properties of curing bone cement. To consider subjective cementation techniques, a method has been devised where a surgeon indicates early and late doughing stages for a PMMA bone cement within a clinical environment. A computer interface has been developed to plot the real-time properties of the cement that are measured using the self-sensing device concurrently. The range of practical variability of cement delivery properties is then established. In order to investigate the effect of cement viscosity on the level of interdigitation a rig has been developed in which cement is applied to a standardised bone analogue under controlled conditions. The open pore ceramic analogue has been shown through microCT scanning to have a structure that is representative of the trabecular structure in human bone. CMC solution is used to represent back bleeding. Once set, the sample is evaluated using microCT to measure the level of interdigitation.

Results: Preliminary results show that bone cement has largely viscous properties following mixing and largely elastic properties towards setting. Values of dynamic viscosity obtained show the cement to have a low viscosity following mixing, then as polymer beads begin to dissolve in the monomer, the viscosity rapidly increases. The rate of viscosity increase then slows as polymer chains are created, before a final rapid increase in viscosity indicating the onset of setting.

Conclusion: A validated method has been developed to measure the viscoelastic properties of curing bone cement at key stages in arthroplasty procedures and to investigate the effect of these viscoelastic properties using a simple standardised bone model.