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Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_7 | Pages 137 - 137
1 May 2016
Abouel-Enin S Fraig H Griffiths J Latham J
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Introduction

Trial reduction while performing total hip replacement is an essential step of the procedure. This is to check the stability of the hip joint with the selected implant sizes and to assess the leg length to avoid discrepancy.

Disengagement of the femoral head trial from the femoral rasp stem, with subsequent migration of the trial head into the pelvic cavity is a rare occurrence, but can be a very frustrating complication to both the surgeon and occasionally the patient.

We present our experience with this exceptional situation and different management options, together with systematic review of the literature.

Patients and methods

We conducted Medline database search via Pubmed interface. MeSH search was used. Systematic review of English literature case reports was performed.

15 reports were found discussing intra-pelvic migration of different arthroplsty related materials.

The total number of reported cases was 24 cases, out of those, 21 cases were related to migration of femoral trial head, 2 cases of migrated modular hemiarthroplasty bipolar heads and one case of migrated femoral head definitive implant.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_7 | Pages 7 - 7
1 May 2016
Griffiths J Abouel-Enin S Yates P Carey-Smith R Quaye M Latham J
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In a society whereby the incidence of obesity is increasing and medico-legal implications of treatment failure are more frequently ending with the consulting doctor, clarity is required as to any restrictions placed on common orthopaedic implants by manufacturing companies. The aim of this study was to identify any restrictions placed on the commonly used femoral stem implants in total hip replacement (THR) surgery, by the manufacturers, based on patient weight. The United Kingdom (UK) National Joint Registry (NJR) was used to identify the five most commonly used cemented and uncemented femoral stem implants during 2012. The manufacturing companies responsible for these implants were asked to provide details of any weight restrictions placed on these implants. The Corail size 6 stem is the only implant to have a weight restriction (60Kg). All other stems, both cemented and uncemented, were free of any restrictions. Fatigue fracture of the femoral stem has been well documented in the literature, particularly involving the high nitrogen stainless steel cemented femoral stems and to a lesser extent the cemented cobalt chrome and uncemented femoral stems. In all cases excessive patient weight leading to increased cantilever bending of the femoral stem was thought to be a major factor contributing to the failure mechanism. From the current literature there is clearly an association between excessive patient weight and fatigue failure of the femoral stem. We suggest avoiding, where possible, the insertion of small stems (particularly cemented stems) and large offset stems (particularly those with a modular neck) in overweight patients.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_2 | Pages 4 - 4
1 Jan 2016
Latham J Goriainov V Pedersen R Gadegaard N Dunlop D Oreffo R
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Background

In 2012, the National Joint Registry recorded 86,488 primary total hip replacements (THR) and 9,678 revisions (1). To date aseptic loosening remains the most common cause of revision in hip and knee arthroplasty, accounting for 40% and 32% of all cases respectively and emphasising the need to optimise osseointegration in order to reduce revisions. Clinically, osseointegration results in asymptomatic stable durable fixation of orthopaedic implants. Osseointegration is a complex process involving a number of distinct mechanisms affected by the implant surface topography, which is defined by surface orientation and surface roughness. Micro- and nano-topography levels have discrete effects on implant osseointegration and yet the role on cell function and subsequent bone implant function is unknown. Nanotopography such as collagen banding is a critical component influencing the SSC niche in vivo and has been shown to influence a range of cell behaviours in vitro (2,3). We have used unique fabricated nanotopographical pillar substrates to examine the function of human bone stem cells on titanium surfaces.

Aim

To investigate the effect of nanotopographical cues on adult skeletal stem cell (SSC) fate, phenotype and function within in-vitro environments.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 69 - 69
1 Jan 2016
Latham J Locker D Tilley S
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Aims

This retrospective study aimed to determine the causes of in-hospital death after Neck of Femur (NOF) fracture in Southampton General Hospital (SGH) over a 6 year period, comparing the clinical cause of death with findings at post-mortem. A previous study showed discrepancies between pre-mortem clinical diagnosis and autopsy findings after in-hospital deaths in SGH.

Methods

The study included all patients who died in SGH after NOF fracture from 2007–2013. Case notes were reviewed to determine the pre-mortem clinical diagnosis and compared with the autopsy findings to analyse major and minor discrepancies. Data were also analysed from the period 1997–2003 in order to compare the causes of death.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 115 - 115
1 Dec 2013
Latham J Cook R Bolland B Yasen S
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Background

Large diameter chrome cobalt modular heads in hip replacement surgery have caused one of the biggest challenges to face orthopaedic surgeons, manufacturers and regulators in a generation. Increasing numbers of retrieved implants offer the opportunity to look in detail at the modes of failure of these devices.

Methods

We have examined the mechanical behaviour of the head taper/trunnion using a variety of techniques including:

mechanical testing in a custom-made jig

3D nano-precision form profilometry (RedLux)

optical 3D microscopy with focus variation technology

electro-chemical testing.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 388 - 388
1 Dec 2013
Latham J Cook R Bolland B Wakefield A Culliford D Tilley C
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Introduction

Metal on metal hip arthroplasty continues to be controversial. Emerging evidence suggests that there are multiple modes of failure, and that the results of revision surgery are influenced by host and implant factors.

Methods

This study compares a single surgeon series of hip resurfacings (Birmingham Hip Resurfacing {BHR}) and large diameter metal on metal total hip replacements (LDMOMTHR). Primary outcome measures included survival rates, failure secondary to histologically identified Adverse Reaction to Metal Debris (ARMD), and patient reported outcome measures (Oxford Hip Score {OHS}) following revision.

Between 1999 and 2005, 458 BHR and 175 LDMOMTHR were performed. At latest review 43 BHR's (9.4%) and 28 LDMOMTHR's (14%) have been revised.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 36 - 36
1 Dec 2013
Cook R Shearwood-Porter N Nicolae C Bolland B Latham J Wood R
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Introduction:

Cemented femoral components have been used in hip replacement surgery since its inception. For many patients this works well, but recent retrieval studies1–4 and more fundamental studies5, 6 have highlighted the issues of damage and material loss from the both matt and polished cemented stems.

Materials and methods:

This study will focus on a cohort of retrievals from the Southampton Orthopaedics Centre for Arthroplasty Retrieval Surgery (SOCARS). The cohort consisted of a number of hybrid modular total hip replacements with cemented femoral components, both from mixed and matched manufacturer stem and head combinations. Femoral stems were polished, collarless, tapered designs; head sizes ranged from 28–54 mm. For each femoral stem, samples of Palacos R + G cement (Heraeus Medical GmbH, Hanau, Germany) were retrieved from the proximal region of the cement mantle (Gruen zones 1 and 7), corresponding to both macroscopically damaged and undamaged surfaces of the stem. The areas of damage were determined using calibrated digital photography; damaged surfaces were then imaged in detail using an Alicona InfiniteFocus microscope (Alicona Imaging GmbH, Graz, Austria). The technique uses optical microscopy and focus variation technology to extract 3D morphology and depth information from the surface with a resolution of 10 nm. A series of measurements were made and two different analysis routes were used to provide volumetric material loss measurements from the stem surface. High-resolution microscopy and elemental analysis of the cement and stem surfaces was conducted via SEM and EDX to identify the mechanisms leading to material loss at the cement-stem interface.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 18 - 18
1 Mar 2013
Bolland B Maul C Cook R Roques A Tuke M Wood R Latham J
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The poor outcome of large head metal on metal total hip replacements (LHMOMTHR) in the absence of abnormal wear at the articulating surfaces has focussed attention on the trunnion / taper interface. The RedLux ultra-precision 3D form profiler provides a novel indirect optical method to detect small changes in the form and surface finish of the head taper as well as a quantitative assessment of wear volume. This study aimed to assess and compare qualitatively the tapers from well functioning small diameter, with poorly functioning LHMOMTHR's using the above technique.

Method

3 groups of retrieval tapers were analysed (Group 1: 28 mm CoCr heads from well functioning MOMTHRs (n=5); Group 2: Large diameter CoCr heads from LHMOMTHRs revised for failure secondary to adverse reaction to metal debris (n=5); Gp 3 (control): 28 mm heads from well functioning metal on Polyethylene (MOP) THRs; n=3). Clinical data on the retrievals was collated. The Redlux profiling of modular head tapers involves a non direct method whereby an imprint of the inside surface of a modular head is taken, and this is subsequently scanned by an optical non contact sensor using dedicated equipment [1]. The wear was also measured on the bearing surface [1]. RedLux profiling of the tapers produced a taper angle and 3D surface maps. The taper angles obtained with the Redlux method were compared to those obtained using CMM measurement on 3 parts. The Redlux profiling, including imprints, was also repeated 3 times to gauge potential errors.

Results

There was no difference in mean 12/14 taper angles between groups. There was no difference in volumetric and linear wear at the bearing surface between groups. Only the LHMOMs showed transfer of pattern from the stem to the internal head taper, with clear demarcation of the contact and damaged area between head taper and stem trunnion (see figure 1 – interpretation of head taper surface features demonstrated using Redlux optical imaging). 3D surface mapping demonstrated wear patterns compatible with motion or deformations between taper and trunnion in the LHMOM group. These appearances were not seen in tapers from small diameter MOM and MOP THRs (see Figure 2).


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 19 - 19
1 Mar 2013
Bolland B Tilley S Tilley C Cook R Latham J
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Pseudotumour formation is being reported with increasing frequency in failing metal-on-metal hip resurfacings and replacements. This mode of failure complication has also been reported with metal-on-polyethylene bearing bearings when it is usually associated with evidence of surface corrosion and no apparent wear at the head–neck taper.

We present a case with evidence of taper wear and damage secondary to corrosion in an uncemented total hip replacement with a metal on polyethylene articulation (TMZF (Titanium, Molybdenum, Zirconium and Ferrous) Accolade® stem, Trident® HA coated acetabular shell, Low Friction Ion Treatment (LFIT™) Cobalt-Chrome anatomic head (40 mm), X3® polyethylene liner)

Case

A 69 year old woman had a THR in 2008. A year later she started to complain of lateral based hip pain. Clinical examination and initial imaging indicated trochanteric bursitis and heterotopic bone formation. The symptoms became worse over the next 3 years and the patient was listed for exploration and excision of heterotopic bone.

Surgical findings

Extensive pseudotumour was encountered deep to bursa and adherent to capsule. Abductors, external rotators and vastus lateralis were spared. There was minimal calcar osteolysis and marginal erosion in superior acetabulum. There was no obvious wear on the articulating surfaces of the femoral head and polyethylene inlay of the socket nor was there any evidence of neck-to-rim impingement or edge loading. There was visible blackening of both the taper and trunnion after femoral head removal.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 139 - 139
1 Jan 2013
Bolland B Maul C Cook R Roques A Wood R Latham J
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The poor outcome of large head metal on metal total hip replacements (LHMOMTHR) in the absence of abnormal wear at the articulating surfaces has focussed attention on the trunnion/taper interface. The RedLux ultra-precision 3D form profiler provides a novel indirect optical method to detect small changes in form and surface finish of the head taper as well as a quantitative assessment of wear volume. This study aimed to assess and compare qualitatively the tapers from small diameter with LHMOMTHR's. 3 groups of retrieval tapers were analysed (Group 1: 28mm CoCr heads from MOMTHRs (n=5); Group 2: Large diameter CoCr heads from LHMOMTHRs (n=5); Group 3: 28mm heads from metal on polyethylene (MOP) THRs; n=3). Clinical data on the retrievals was collated. Both bearing surfaces and head tapers were measured for wear using the Redlux profiling non contact measurement system. Measurements included taper angle and 3D surface maps. Taper angles obtained with the Redlux method were compared to those obtained using CMM measurement on 3 parts. The Redlux profiling, including imprints, was also repeated 3 times to gauge potential errors. There was no difference in mean 12/14 taper angles between groups. There was no difference in volumetric and linear wear at the bearing surface between groups. Only the LHMOMs showed transfer of pattern from the stem to the internal head taper, with clear demarcation of the contact and damaged area between head taper and stem trunnion. 3D surface mapping demonstrated wear patterns compatible with motion or deformations between taper and trunnion in the LHMOM group alone. Discussion: Differences in appearance of the taper surface between LHMOMTHRs and MOP or MOM small diameter devices highlight an area of concern and potential contributor to the mode of early failure. Further work is required to fully qualify the Redlux method capabilities.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 4 - 4
1 Sep 2012
Bolland B Culliford D Langton D Millington J Arden N Latham J
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This study reports the mid-term results of a large bearing hybrid metal on metal total hip replacement (MOMHTHR) in 199 hips (185 patients) with mean follow up of 62 months. Clinical, radiological, metal ion and retrieval analysis were performed.

Seventeen patients (8.6%) had undergone revision, and a further fourteen are awaiting surgery (defined in combination as failures). Twenty one (68%) failures were females. All revisions and ten (71%) awaiting revision were symptomatic. Twenty four failures (86%) showed progressive radiological changes.

Fourteen revision cases showed evidence of adverse reactions to metal debris (ARMD). The failure cohort had significantly higher whole blood cobalt ion levels (p=0.001), but no significant difference in cup size (p=0.77), inclination (p=0.38) or cup version (p=0.12) compared to the non revised cohort. Female gender was associated with increased risk of failure (p=0.04). Multifactorial analysis demonstrated isolated raised Co levels in the absence of symptoms or XR changes were not predictive of failure (p=0.675). However the presence of pain (p<0.001) and XR changes (p<0.001) in isolation were significant predictors of failure. Wear analysis (n=5) demonstrated increased wear at the trunnion/head interface (mean out of roundness measurements 34.5 microns (normal range 8–10 microns) with normal wear levels at the articulating surfaces. Macroscopically corrosion was evident at the proximal and distal stem surfaces. Cumulative survival rate, with revision for any reason was 92.4% (95%CI: 87.4–95.4) at 5 years. Including those awaiting surgery, the revision rate would be 15.1% with 89.6% (95% CI: 83.9–93.4). Cumulative survival at 5 years.

This MOMHTHR series has demonstrated unacceptable high failure rates with evidence of high wear at the head/trunnion interface and passive corrosion to the stem surface. Female gender was an independent risk factor of failure. Metal ion levels remain a useful aspect of the investigation work up but in isolation are not predictive of failure.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXII | Pages 11 - 11
1 Jul 2012
Edwards D Millington J Dunlop D Higgs D Latham J
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With an increasing ageing population and a rise in the number of primary hip arthroplasty, peri-prosthetic fracture (PPF) reconstructive surgery is becoming more commonplace. The Swedish National Hip Registry reported that, in 2002, 5.1% of primary total hip replacements required revision due to PPF. Laboratory studies have indicated that age, bone quality and BMI all contribute to an increased risk of PPF. Osteolysis and aseptic loosening contribute to the formation of loosening zones as described by Gruen, with subsequent increased risk of fracture. The aim of the study was to identify significant risk factors for PPF in patients who have undergone primary total hip replacement (THR).

Logbooks of three Consultant hip surgeons were filtered for patients who had THR-PPF fixation subsequent to trauma. Risk factors evaluated included sex, age, bone density (Singhs index), loosening zones, Vancouver classification, prosthesis stem angle relative to the axis of the femur, and length of time from THR to fracture. A control group of uncomplicated primary THR patients was also scrutinised.

Forty-six PPF were identified representing 2.59% of THR workload. The male: female ratios in both groups were not significantly different (1:1.27 and 1:1.14 respectively). Average age of PPF was 72.1, which was significantly older than the control group (54.7, p>0.05). The commonest type of PPF was Vancouver type B. Whilst stem position in the AP plane was similar in both groups, in lateral views the PPF stem angle demonstrated significant antero-grade leg position compared to the non-PPF group (p.0.05). The PPF group demonstrated a greater number of loosening zones in pre-fracture radiographs compared to the control group (2.59 and 1.39 respectively, p>0.05)

Our workload from PPF reflects that seen in Europe. Age, stem position and the degree of stem loosening appear to contribute to the risk of a peri-prosthetic fracture.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IV | Pages 13 - 13
1 Mar 2012
Garrett S Bolland B Yates P Latham J
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Introduction and aim

One of the suggested advantages of hip resurfacing arthroplasty is that it offers the possibility of straightforward revision. As the femoral canal is not violated during the resurfacing procedure, it is postulated that the outcome of revision surgery should be equivalent to that of a primary hip arthroplasty. The purpose of this study was to investigate whether revision was as straightforward and as successful as has been suggested.

Method

14 patients underwent revision surgery due to the failure of the femoral component of their Birmingham hip resurfacing. The femoral component was revised to a cemented Zimmer CPT stem, with a large modular metal head (MMT). The acetabular component was found to be well fixed and was left in situ. Radiographs were studied to review any change in offset. These patients were matched with a group who had undergone a hybrid total hip arthroplasty as a primary procedure, using the same bearing. The Oxford and Harris Hip scores were used to measure outcome.