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Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 135 - 135
1 Jul 2014
Brochhausen C Grevenstein D Grevenstein J Mamilos A Schmitt V Kirkpatrick C
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Summary Statement

Re-biopsies of five patients after spheroid-based, scaffold-free autologous chondrocyte transplantation revealed regeneration of cartilage with immunohistochemical characteristics of articular cartilage.

Introduction

Traumatic lesions of articular cartilage represent a crucial risk-factor for cartilage degradation and osteoarthritis, because the regenerative capacity of articular cartilage is highly limited. Even if there exist several strategies to treat traumatic cartilage damages such as the classical autologous chondrocyte transplantation (ACT) or matrix assisted ACT, the optimal solution is not yet been found since transplantation errors are known. A relatively new strategy represents the scaffold-free spheroid based autologous chondrocyte transplantation. After harvesting articular cartilage in this strategy spheroids of chondrocytes will be synthesised after chondrocyte isolation and expansion. The spheroids will be implanted and rest at the transplantation site by adhesion.