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Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_12 | Pages 87 - 87
1 Dec 2022
Al-Mohrej O Prada C Madden K Shanthanna H Leroux T Khan M
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Emerging evidence suggests preoperative opioid use may increase the risk of negative outcomes following orthopedic procedures. This systematic review evaluated the impact of preoperative opioid use in patients undergoing shoulder surgery with respect to preoperative clinical outcomes, postoperative complications, and postoperative dependence on opioids.

EMBASE, MEDLINE, CENTRAL, and CINAHL were searched from inception to April, 2021 for studies reporting preoperative opioid use and its effect on postoperative outcomes or opioid use. The search, data extraction and methodologic assessment were performed in duplicate for all included studies.

Twenty-one studies with a total of 257,301 patients were included in the final synthesis. Of which, 17 were level III evidence. Of those, 51.5% of the patients reported pre-operative opioid use. Fourteen studies (66.7%) reported a higher likelihood of opioid use at follow-up among those used opioids preoperatively compared to preoperative opioid-naïve patients. Eight studies (38.1%) showed lower functional measurements and range of motion in opioid group compared to the non-opioid group post-operatively.

Preoperative opioid use in patients undergoing shoulder surgeries is associated with lower functional scores and post-operative range of motion. Most concerning is preoperative opioid use may predict increased post-operative opioid requirements and potential for misuse in patients.


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_13 | Pages 29 - 29
1 Dec 2022
Alolabi B Shanthanna H Czuczman M Moisiuk P O'Hare T Khan M Forero M Davis K Moro JK Foster G Thabane L
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Interscalene brachial plexus block is the standard regional analgesic technique for shoulder surgery. Given its adverse effects, alternative techniques have been explored. Reports suggest that the erector spinae plane block may potentially provide effective analgesia following shoulder surgery. However, its analgesic efficacy for shoulder surgery compared with placebo or local anaesthetic infiltration has never been established.

We conducted a randomised controlled trial to compare the analgesic efficacy of pre-operative T2 erector spinae plane block with peri-articular infiltration at the end of surgery. Sixty-two patients undergoing arthroscopic shoulder repair were randomly assigned to receive active erector spinae plane block with saline peri-articular injection (n = 31) or active peri-articular injection with saline erector spinae plane block (n = 31) in a blinded double-dummy design. Primary outcome was resting pain score in recovery. Secondary outcomes included pain scores with movement; opioid use; patient satisfaction; adverse effects in hospital; and outcomes at 24 h and 1 month.

There was no difference in pain scores in recovery, with a median difference (95%CI) of 0.6 (-1.9-3.1), p = 0.65. Median postoperative oral morphine equivalent utilisation was significantly higher in the erector spinae plane group (21 mg vs. 12 mg; p = 0.028). Itching was observed in 10% of patients who received erector spinae plane block and there was no difference in the incidence of significant nausea and vomiting. Patient satisfaction scores, and pain scores and opioid use at 24 h were similar. At 1 month, six (peri-articular injection) and eight (erector spinae plane block) patients reported persistent pain.

Erector spinae plane block was not superior to peri-articular injection for arthroscopic shoulder surgery.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_7 | Pages 1 - 1
1 Jul 2020
Paul R Maldonado-Rodriguez N Docter S Leroux T Khan M Veillette C Romeo A
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Reverse total shoulder arthroplasty (RSA) with glenoid bone grafting has become a common option for the management of significant glenoid bone loss and deformity associated with glenohumeral osteoarthritis. Despite the increasing utilization of this technique, our understanding of the rates of bone graft union, complications and outcomes are limited. The objectives of this systematic review are to determine 1) the overall rate of bone graft union, 2) the rate of union stratified by graft type and technique, 3) the reoperation and complication rates, and 4) functional outcomes, including range of motion (ROM) and functional outcome scores following RSA with glenoid bone grafting.

A comprehensive search of MEDLINE, Embase, and CINAHL databases was completed for studies reporting outcomes following RSA with glenoid bone grafting. Inclusion criteria included clinical studies with greater than 10 patients, and minimum follow up of one year. Studies were screened independently by two reviewers and quality assessment was performed using the MINORs criteria. Pooled and frequency-weighted means and standard deviations were calculated where applicable.

Overall, 15 studies were included, including nine retrospective case series (level IV), four retrospective cohort studies (level III), one prospective cohort study (level II) and one randomized control trial (level I). The entire cohort consisted of 555 patients with a mean age of 71.9±2.1 years and 70 percent female. The mean follow-up was 33.8±9.4 months. Across all procedures, 84.9% (N=471) were primary arthroplasties, and 15.1% (N=84) were revisions. The overall graft union rate was 89.2%, but was higher at 96.1% among studies that used autograft bone (9 studies, N=308). When stratified by technique, bone graft for the purposes of lateralization resulted in a 100% union rate (4 studies, N=139), while eccentric bone grafts used in asymmetric bone loss resulted in a lower union rate of 84.9% (10 studies, N=345). The overall revision rate was 6.5%, and was lowest following primary cases at 1.8% (11 studies, N=393). The pooled mean scapular notching rate was 20.1% (12 studies, N=497). Excluding notching, the pooled mean complication rate was 21.5% for all cases and 13% for primary cases (11 studies, N=393). When reported, there was significant improvement in post-operative ROM in all planes. There was also improvement in functional outcome scores, whereby the frequency-weighted mean Constant score increased from 25.9 to 67.2 (8 studies, N=319), ASES score increased from 34.7 to 75.2 (4 studies, N=142), and SST score increased from 2.1 to 7.6 (5 studies, N=196) at final follow up.

This review demonstrates that glenoid bone grafting with RSA results in good mid-term clinical and radiographic outcomes. Union rate appears to depend highly on graft type and technique, whereby the highest union rates were seen following the use of autograft bone for the purposes of lateralization. Interestingly, the union rate of autograft bone for the purposes of augmentation in eccentric bone loss is considerably lower and its impact on the long-term survivorship of the implant remains unknown.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_6 | Pages 97 - 97
1 Jul 2020
Khan M Liu EY Hildebrand AH Athwal G Alolabi B Horner N
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Heterotopic Ossification (HO) is a known complication that can arise after total elbow arthroplasty (TEA). In most cases it is asymptomatic, however, in some patients it can limit range of motion and lead to poor outcomes. The objective of this review was to assess and report incidence, risk factors, prophylaxis, and management of HO after TEA.

A systematic search was conducted using MEDLINE, EMBASE, and PubMed to retrieve all relevant studies evaluating occurrence of HO after TEA. The search was performed in duplicate and a quality assessment was performed of all included studies.

A total of 1907 studies were retrieved of which 45 studies were included involving 2256 TEA patients. HO was radiographically present in 10% of patients and was symptomatic in 3%. Less than 1% of patients went on to surgical excision of HO, with outcomes following surgery reported as good or excellent as assessed by range of motion and Mayo Elbow Performance Scores (MEPS). TEA due to ankylosis, primary osteoarthritis, and posttraumatic arthritis are more likely to develop symptomatic HO.

HO is an uncommon complication following TEA with the majority of patients developing HO being asymptomatic and requiring no surgical management. Routine HO prophylaxis for TEA is not supported by the literature. The effectiveness of prophylaxis in high risk patients is uncertain and future studies are required to clarify its usefulness. The strength of these conclusions are limited by inconsistent reporting in the available literature.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_6 | Pages 90 - 90
1 Jul 2020
Madden K Petrisor B Del Fabbro G Khan M Joslin J Bhandari M
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Brazilian jiu-jitsu (BJJ) is a grappling-based martial art which can lead to injuries both in training and in competitions. There is a paucity of data regarding injuries sustained while training in Brazilian jiu-jitsu both in competitive and non-competitive jiu-jitsu athletes. Our primary objective was to determine the prevalence of injuries sustained during jiu-jitsu training and competition. Our secondary objectives were to describe the types of injuries, and to determine which participant and injury characteristics are associated with desire to discontinue jiu-jitsu following injury, and characteristics are associated with requiring surgery for an injury.

We conducted a survey of all BJJ participants at one club in Hamilton Ontario. We developed a questionnaire using focus groups, key informants and the previous literature. The questionnaire included questions on demographics, injuries in competition and/or training, treatment received, and whether the participant considered discontinuing BJJ following injury. The primary analysis was descriptive. The secondary analysis consisted of unadjusted logistic regression analyses to evaluate the association between selected demographic and injury patterns and those who considered quitting jiu-jitsu as a result of their injuries as a dependent variable.

Seventy BJJ athletes participated in this study (response rate 85%). The majority of respondents were male (90%), over the age of 30 years (58.6%), and junior trainees (white belts [37.2%] or blue belts [42.9%]). Ninety one percent of participants were injured in training and 60% of competitive athletes were injured in competitions. Significantly more injuries were sustained overall (p < 0 .001) for each body region (p∼0.001) in training in comparison to competition. Two-thirds of injured participants required medical attention, with 15% requiring surgery. Participants requiring surgical treatment were six and a half times more likely to consider quitting compared to those requiring other treatments, including no treatment (OR: 6.50, 95% CI: 1.53–27.60). Participants required to take more than four months off training were five and a half times more likely to consider quitting compared to those who took less time off (OR: 5.48, 95% CI: 2.25–13.38).

We identified that nine out of ten jiu-jitsu practitioners surveyed suffered injury while in training and the most severe injuries for the majority of practitioners occurring during training. The most common injuries identified involved the fingers, neck, knee, and shoulder, with the majority of respondents seeking medical or surgical treatment or requiring physiotherapy or rehabilitation. Potential participants in BJJ should be informed regarding significant risk of injury and instructed regarding appropriate precautions and safety protocols. BJJ practitioners and instructors should be especially cognizant of safety during training, where the majority of injuries occur.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_6 | Pages 98 - 98
1 Jul 2020
Khan M Alolabi B Horner N Ayeni OR Bedi A Bhandari M
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Shoulder impingement is one of the most common non-traumatic upper limb causes of disability in adults. Often resulting in pain and disability, management remains highly debated. This meta-analysis of randomized trials aims to evaluate the efficacy of surgical intervention in the setting of shoulder impingement in comparison to non-operative or sham treatments.

Two reviewers independently screened MEDLINE, EMBASE, PUBMED and Cochrane databases for randomized control trials published from 1946 through to May 19th, 2018. A risk of bias assessment was conducted for all included studies and outcomes were pooled using a random effects model. The primary outcome was improvement in pain up to two years. Secondary outcomes included functional outcome scores reported at the short term (/=2 years). Heterogeneity was assessed using the I2statistic. Functional outcome scores were presented along with minimal clinically important differences to provide clinical context to findings.

Twelve RCT's (n=1062 patients) were included in this review. Eligible patients were a mean age of 48 (SD +/− 4) years with 45% being male gender. The pooled treatment effect of surgical intervention for shoulder impingement did not demonstrate any benefit to surgery with respect to pain relief (mean difference [MD] −0.07, 95% CI −0.40 to 0.26) or short-term functional outcomes (standardized mean difference [SMD] −0.09, 95% confidence interval [CI] −0.27 to 0.08). Surgical intervention did result in a small statistically significant but clinically unimportant improvement in long term functional outcomes (SMD 0.23, 95% CI 0.06 to 0.41).

Evidence suggests surgical intervention has little, if any, benefit for impingement pathology in the middle-aged patient.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_6 | Pages 96 - 96
1 Jul 2020
Khan M Alolabi B Horner N Stride D Wang J
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Ankle fractures are the fourth most common fracture requiring surgical management. The deltoid ligament is considered the primary stabilizer of the ankle against a valgus force. The management of the deltoid ligament in ankle fractures is currently a controversial topic no consensus exists regarding repair in the setting of ankle fractures. The purpose of this systematic review is to examine the role and indications for deltoid ligament repair in ankle fractures.

A systematic database search was conducted with Medline, Pubmed and Embase for relevant studies discussing patients with ankle fractures involving deltoid ligament rupture and repair. The papers were screened independently and in duplicate by two reviewers. Study quality was evaluated using the MINORs criteria. Data extraction included post-operative outcomes, pain, range of motion (ROM), function, medial clear space (MCS), syndesmotic malreduction and complication rates.

Following title, abstract and full text screening, 10 eligible studies published between 1987 and 2017 remained for data extraction (n = 528). The studies include 325 Weber B and 203 Weber C type fractures. Malreduction rate in studies with deltoid ligament repair was 7.4% in comparison to those without repair at 33.3% (p < 0.05). Eleven (4%) of deltoid ligament repair patients returned for re-operation to have implants removed in comparison to eighty three (42%) of those without repair (p < 0.05). There was no significant difference for pain, function, ROM, MCS and complication rates (p < 0.05). The mean operating time of deltoid ligament repair groups was 20 minutes longer than non-repair groups(p < 0.05).

Deltoid ligament repair offers significantly lower syndesmotic malreduction rates and reduced re-operation rates for hardware removal when performed instead of transsyndesmotic screw fixation. When compared to non-repair groups, there are no significant differences in pain, function, ROM, MCS and complication rates. Deltoid ligament repair should be considered for ankle fracture patients with syndesmotic injury, especially those with Weber C. Other alternative syndesmotic fixation methods such as suture button fixation should be explored. A large multi-patient randomized control trial is required to further examine the outcomes of ankle fracture patients with deltoid ligament repair.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_21 | Pages 21 - 21
1 Dec 2016
Bhandari M Khan M Ayeni O Madden K Bedi A Ranawat A Kelly B Sancheti P Ejnisman L Tsiridis E
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Femoroacetabular impingement (FAI) is a common cause of hip pain in the young adult. Uncertainty regarding surgical indications, outcome assessment, management preferences and perceptions of the literature exist. We conducted a large international survey assessing the perceptions and demographics of orthopaedic surgeons regarding FAI.

A survey was developed using previous literature, focus groups and a sample-to-redundancy strategy. The survey contained forty-six questions and was emailed to national orthopaedic associations and orthopaedic sports medicine societies for member responses. Members were contacted on multiple occasions to increase response rates.

Nine hundred orthopaedic surgeons from twenty national and international organisations completed the survey. Surgeons responded across 6 continents, 58.2 % from developed nations with 35.4 % having sports fellowship training. North American and European surgeons reported significantly greater exposure to hip arthroscopy during residency and fellowships in comparison to international respondents (48.0% vs. 44.5% vs. 25.6% respectively; p<0.001). Surgeons performing a higher volume of FAI surgery (over 100 cases per year) were significantly more likely to have practiced for more than 20 years (OR 1.91; 95% CI 1.01 to 3.63), be practicing at an academic hospital (OR 2.25; 95% CI 1.22 to 4.15), and have formal arthroscopy training (OR 46.17; 95% CI 20.28 to 105.15). High volume surgeons were over two-fold more likely to practice in North America and Europe (OR 2.26; 95% CI: 1.08 to 4.72).

The exponential rise in the diagnosis and surgical management for FAI appears to be driven largely by experienced surgeons in developed nations. Our analysis suggests that although FAI management is early in the innovation cycle we are at a tipping point towards wider uptake and utilisation. The results of this survey will help guide further research and study.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_18 | Pages 31 - 31
1 Dec 2014
Karuppaiah K Khan M Sinha J Arya A
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Contoured locking plates are commonly used to fix the proximal humerus fractures. Their long-term results are unknown. We present long-term radiological and functional outcome of three and four part fractures of the proximal humerus treated with PHILOS plate.

We prospectively analysed 53 consecutive three and four part proximal humerus fractures treated with PHILOS plate between 2002 and 2007. Patients were assessed using Oxford Shoulder Score and DASH score. 44 fractures (21 three part and 23 four part) were available at the final follow up.

At a mean follow-up of 8.5 years (6.4 years–10.8 years) the average Oxford Shoulder Score was 43.9 (range 23–48) and the average DASH score was 7.7 (range 0–36.7). 30% of patients required re-operation (five for hemiarthroplasty, three for impingement syndrome, five for removal of implant). Avascular necrosis (AVN) developed in 10 patients, of which only three required hemiarthroplasty. All except one patient were satisfied with the result of their operation.

Our study supports the use of locking plates for the treatment of three and four part proximal humeral fractures. In spite of some patients requiring secondary surgical intervention in the first few years, the function of the shoulder continues to improve and in the long term patients were satisfied with the outcome. An important finding of our study is that the post-traumatic AVN of humeral head does not necessarily need major surgical intervention. We believe that the possibility of avascular necrosis should not be a major determinant in the choice of surgical treatment of proximal humeral fractures.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_32 | Pages 4 - 4
1 Sep 2013
Bradley B Griffiths S Stewart K Khan M Higgins G Hockings M Isaac D
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In the current austere financial climate within the NHS where local healthcare Trusts are reimbursed in a Payment by Results system it is important that we accurately identify the costs associated with surgical procedures.

We retrospectively reviewed data of 589 consecutive patients undergoing lower limb arthroplasty surgery and recorded their age, BMI and co-morbidities. The effect of these parameters on operative duration and length of stay (LOS) was analysed.

We demonstrate that for a 1 point increase in BMI we expect LOS to increase by a factor of 2.9% (p<0.0001) and mean theatre time to increase by 1.46 minutes (p<0.0001). We also show that for a l-year increase in age, we expect LOS to increase by a factor of 1.2% (p<0.0001).

We have calculated the extra financial costs associated with this and believe that the current OPCS coding system for obesity underestimates the financial impact of increasing BMI and age on lower limb arthroplasty Trusts are being inadequately reimbursed.

The results of this study have been used to produce a chart that allows prediction of LOS following lower limb arthroplasty based on BMI and age. We also believe that the data produced is of use in planning operating lists.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_28 | Pages 46 - 46
1 Aug 2013
Khan M Jilani L Deep K
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Introduction

Malalignment of lower limb is a common feature in patients with osteoarthritis (OA). This, either cause or effect of OA, is known to alter the normal anatomy of knee and affects progression of wear and tear in mechanically stressed compartment. We investigated the relationship of mechanical axis to wear and tear in varus, neutral and valgus knees.

Materials and Methods

A retrospective analysis of 136 consecutive patients, with OA, who underwent total knee replacement using computer navigation. The thickness of medial and lateral cuts of distal femur and proximal tibia were recorded. Pre-op coronal deformity was assessed using long leg radiographs and Femoral Tibial Mechanical Angle (FTMA) calculated. Patients were evaluated as one group and three subgroups based on preop varus, neutral or valgus lower limb alignment. Student t test and Pearson's correlation coefficient were used for statistical analysis.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_28 | Pages 47 - 47
1 Aug 2013
Deep K Khan M Goudie S
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Introduction

Restoration of normal hip biomechanics is vital for success of total hip arthroplasty (THA). This requires accurate placement of implants and restoration of limb length and offset. The purpose of this study was to assess the precision and accuracy of computer navigation system in predicting cup placement and restoring limb length and offset.

Material and Methods

An analysis of 259 consecutive patients who had THA performed with imageless computer navigation system was carried out. All surgeries were done by single surgeon (KD) using similar technique. Acetabular cup abduction and anteversion, medialisation or lateralisation of offset and limb length change were compared between navigation measurements and follow-up radiographs. Precision, accuracy, sensitivity and specificity were calculated to assess navigation for cup orientation and student t-test used for evaluation of offset and limb length change. A p value of <0.05 was considered significant for evaluation.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_9 | Pages 10 - 10
1 Feb 2013
Khan M Walter R Loxdale P Davis J
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Proximal interphalangeal joint arthrodesis for lesser toe deformity is commonly stabilised using a Kirschner wire passed through the tip of the toe. Recently, a number of all-inside intramedullary fusion devices have been developed, with the aim of decreasing infection risk through avoiding exposed metalwork. We report our early experience with Stayfuse™ (Nexa Orthopaedics).

Case records of patients undergoing Stayfuse™ proximal interphalangeal joint arthrodesis between July 2009 and November 2011 were examined. Twenty-eight Stayfuse™ proximal interphalangeal joint arthrodesis procedures in 14 patients were performed. Overall, 8 (29%) procedures required revision within 6 months. Of these, 3 (11%) intraoperative failures occurred, requiring immediate revision (Kirschner wire stabilisation or excision arthroplasty). All involved bending failure of the implant clip mechanism. A further 5 (18%) toes required revision procedures within 6 months of the index procedure, 3 (11%) for dissociation of the implant clip mechanism and 2 (7%) for periprosthetic fracture.

For patients perceived to be at higher risk of infective complications, all-inside stabilisation systems are an attractive concept. However, with 29% of patients undergoing revision procedures within 6 months, we question the safety of choosing Stayfuse™ implants over Kirschner wire stabilisation.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 87 - 87
1 Jan 2013
Ibrahim M Khan M Rostom M Platt A
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Introduction/Aim

Flexor tendon injuries of the hand are common with an incidence of over 3000 per annum in the UK. These injuries can affect hand function significantly. Early treatment with optimal repair is crucial to prevent disability.

This study aimed at investigating the re-rupture rate following primary flexor tendon repair at our institution and to identify potential risk factors for re-rupture.

Methods

100 flexor tendons' injuries that underwent primary repair over a one-year period were reviewed retrospectively.

Data was collected on age, gender, occupation, co morbidities, injured fingers, hand dominance, smoking status, zone of injury, time to surgery, surgeon grade, type of repair and suture, and antibiotic use on included patients. Causes of re-rupture were examined. We compared primary tendon repairs that had a re-rupture to those that did not re-rupture. Univariate and multivariate analysis was undertaken to identify the most significant risk factors for re-rupture.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 188 - 188
1 Jan 2013
Srinivas S Dyab H Tait M Khan M Meda M Mackay D
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We reviewed the current screening protocol for MRSA detection in patients admitted for elective lower limb arthroplasty as we thought it may not be cost effective and there is no evidence base for validity of MRSA screening swabs.

The current institutional screening protocol includes MRSA swabs from nose and groin taken on 2 different occasions; the 1st swab taken at time patient was placed on the waiting list and the 2nd swab taken at the Orthopaedic pre-clerking clinic around 6–8 weeks later.

We found that during the study period, of 1791 patients who underwent MRSA screening swabs, only 16 patients had positive results. Of these, 9 patients had known MRSA (2 in care home) and no data was available in 2 patients. However in 5 patients, there was an initial negative swab which later was found to be positive. The time interval in these ranged from 0.6 to 85 weeks (Conversion rate = 0.3%).

The laboratory cost for these screening swabs was £9,027. Given the low prevalence rate of MRSA and low conversion rate at 6 weeks, there is a role for accepting a single-swab screening protocol. This would also result in significant cost savings of around £ 4,500.

We can therefore conclude that in the indigenous population, it is unlikely a patient will de-novo acquire MRSA in the community unless exposed to independent risk factors. We have adopted the new screening protocol where patients are screened routinely for detection and eradication only once prior to admission unless independent risk factors such as previous MRSA colonisation, hospital admission or if being admitted from residential/care home.

There is however no evidence in literature about the time period of validity of MRSA screening swabs.