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Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_23 | Pages 31 - 31
1 Dec 2016
THE INFLUENCE OF TITANIUM AND STEEL FRACTURE FIXATION PLATES WITH DIFFERENT SURFACE TOPOGRAPHIES ON INFECTION RATES IN A RABBIT FRACTURE MODEL
Metsemakers W Schmid T Zeiter S Ernst M Keller I Cosmelli N Arens D Moriarty F Richards G
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Aim

The aim of this study was to define the role of implant material and surface topography on infection susceptibility in a preclinical in vivo model incorporating appropriate fracture biomechanics and bone healing.

Method

The implants included in this experimental study were composed of: standard Electro polished Stainless Steel (EPSS), standard titanium (Ti-S), roughened stainless steel (RSS) and surface polished titanium (Ti-P). In an in vivo study, a rabbit humeral fracture model was used. Each rabbit received one of three Staphylococcus aureus inocula, aimed at determining the infection rate at a low, medium and high dose of bacteria. Outcome measures were quantification of bacteria on the implant and in the surrounding tissues, and determination of the infectious dose 50 (ID50).

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