Significant access morbidity with intercostal neuralgia and post-thoracotomy pain syndrome was reported in case that an anterior approach for spondylodesis of fractures of the thoracolumbar spine was used. We describe our experience with thoracoscopical fusion from anterior as a less invasive approach. Between 02/2007 and 09/2008 in a series of 32 patients (18 male; mean age 43, 17–74yrs) with fractures of the thoracolumbar spine (level Th11: n = 2, level Th12: n = 12, level L1: n = 18; fracture types: A3.1.1: n = 15, A3.2.1: n = 11, A3.3.1: n = 3, B2.1: n = 1 and B2.3: n = 2) thoracoscopical fracture stabilization was performed. A less invasive approach with three portals without an assistant was used facilitated by a new retractor system. In 16 patients fracture stabilization from anterior was supported by an additional spondylodesis using an dorsal approach. For reconstruction of the anterior column a VLIFT-system (n = 19), a Synex- (n = 11) or a Harms-Cage (n = 2) in combination with a MACS-TL (n = 16) or a Arcofix-system (n = 2) were used.Introduction
Patients
Acetabular retroversion is a well-documented cause of femoro-acetabular impingement (FAI). There are few reports of long-term outcomes following correction of retroversion. We hypothesized that correction of acetabular retroversion with peri-acetabular osteotomy (PAO) in young adults with symptomatic FAI can lead to symptomatic relief, improvement of function and thus potentially delay the progression of osteoarthritis. Twenty-two patients (29 hips) underwent Bernese PAO for treatment of symptomatic FAI with acetabular retroversion between April 1997 and August 1999. Mean age at surgery was 23 years (14–41). Mean duration of symptoms was 17 months (6–24). All pre-operative radiographs demonstrated Tönnis grade 0 of degenerative changes. Mean follow up was 127 months (109–142). Clinical, functional and radiographic outcomes are presented. The overall mean Merle d’Aubigné score improved from 14.0 points (12–16) pre-operatively to 16.3 points (14 to 18) at the time of last follow-up. There were three reoperations due to loss of correction, posterior impingement and cam impingement. There were no major vascular or neurologic complications and none related to non- healing of the osteotomies. All patients had symptomatic relief at final follow-up. Range of motion and functional scores improved in all cases (even in those with repeat procedures). The vast majority of patients continued to demonstrate no signs of osteoarthritis (Tönnis greade 0) at final follow-up. Acetabular retroversion is a mechanical factor that can lead to FAI. In symptomatic cases, PAO is a safe and reliable method for correction of the retroversion and can relief symptoms, improve function and prevent rapid progression of osteoarthritis.
Systemic factors are believed to be pivotal for the development of heterotopic ossification in severely-injured patients. In this study, cell cultures of putative target cells (human fibroblastic cells, osteoblastic cells (MG-63), and bone-marrow stromal cells (hBM)) were incubated with serum from ten consecutive polytraumatised patients taken from post-traumatic day 1 to day 21 and with serum from 12 healthy control subjects. The serum from the polytraumatised patients significantly stimulated the proliferation of fibroblasts, MG-63 and of hBM cells. The activity of alkaline phosphatase in MG-63 and hBM cells was significantly decreased when exposed to the serum of the severely-injured patient. After three weeks in 3D cell cultures, matrix production and osteogenic gene expression of hBM cells were equal in the patient and control groups. However, the serum from the polytraumatised patients significantly decreased apoptosis of hBM cells compared with the control serum (4.3% Increased proliferation of osteoblastic cells and reduced apoptosis of osteoprogenitors may be responsible for increased osteogenesis in severely-injured patients.
