Endoscopic techniques lead to higher numbers of anterior procedures to the vertebral column. Navigation systems can assist to more precision using less x-rays. We registered prospectively more than 100 cases of anterior stabilization of the thoracic and lumbar spine using minimally invasive technique, endoscopic assistance and CT-based navigation. Patients were observed continuously over a time period of at least 12 month according to a standardized protocol. 135 patients were recorded prospectively between January 2002 September 2004. All patients recieved anterior procedures using endoscopical assistance. Operations were performed in prone position using Synframe® and navigation system by BrainLab®. The follow up of at least one year consisted in clinical investigations and radiographs 6 weeks, 3, 6, 9 and 12 months post OP. 87 male and 48 female patients were recorded with a mean age of 41 (16–77) years. 47 isolated anterior and 88 combined antero-posterior spondylodeses were performed with the described technique. In 101 cases thoracoscopy was used. For the instrumentation of L3, mini-lumbotomy was necessary which was also combined with Synframe® and endoscopical assistance. Isolated anterior procedures were completed under navigation control in 29 and combined antero-posterior procedures in 71 cases. Image intensifier times were reduced up to 85%, op-times were shortened using navigation for a mean of 22 minutes. Navigation procedures showed initial learning curve. However, after this initial time it was a useful techique to enlarge precision and reduce op-times as well as x-ray exposition. The further standardization of the procedure lead to the development of advantageous instruments that further on will lead to even higher acceptance of this new technique.