The purpose of this preliminary study was to evaluate the feasibility and accuracy of HipAlign (OrthAlign, Inc., USA) system for cup orientation in total hip arthroplasty (THA). The subjects of this study were 5 hips that underwent primary cementless THA via a posterior approach in the lateral decubitus position. Evaluation 1; after reaming acetabular bone, a trial cup was placed in the reamed acetabulum in an aimed alignment using HipAlign. Then, the trial cup alignment was measured using HipAlign and CT-based navigation system in the radiographic definition. Evaluation 2; a cementless cup was placed in the reamed acetabular in an aimed alignment using CT-based navigation and cup alignment was measured using both methods. After operation, we measured the cup alignment using postoperative CT in each patient. In the results, the average cup inclination measured with HipAlign was around 5 degrees of true cup inclination angles. The average cup anteversion with HipAlign tended to be larger than that with CT-based navigation or postoperative CT in both evaluations. That is because there is a difference in the pelvic sagittal tilt between the lateral position and supine position. In conclusion, this study suggests that guiding cup alignment with the use of HipAlign is feasible through a posterior approach and the mean cup inclination measured with HipAlign showed an acceptable level of accuracy, but the mean cup anteversion is not reliable. We need a further modification for pelvic registration to improve the accuracy of cup anteversion.