Previous identification of the infective microorganism First-stage surgery including radical debridement and placement of «personalized» spacers. Specific antibiotic treatment during three months. Second-stage surgery including second debridement, withdrawal of the spacers, collection of samples for microbiologic and histologic study (including intraoperative PMN study). Implantation of prosthesis without use of cement.
Cement with antibiotics is not essential for prosthesis reimplantation when replacement is performed in two-stage. Outcome in patients treated according to this protocol is equal or superior to that of other technique options (eradication of the septic process for a mean of more than 5 years). Prosthesis survival results justify the exclusion of cement for reimplantation.