Background

Elderly patients with hip fractures are often malnourished and in a catabolic state upon admission to hospital. Waiting time for surgery is commonly unpredictable, and often more than 24 hours. Due to an assumed stress-induced delayed gastric emptying time with a possible associated risk of aspiration, fasting guidelines are the same as for other trauma patients. This leads to prolonged fasting time in these patients who are often metabolically compromised, with negative effects on post-operative recovery and prolonged hospital stay. The aim of this study was to investigate if 400 ml of a carbohydrate-rich beverage could be given to patients with a hip fracture 2–3 hours before surgery without carrying a risk of pulmonary aspiration.

A total of 63 women who had an operation for a fracture of the hip was randomly allocated to one year of treatment either with anabolic steroids, vitamin D and calcium (anabolic group) or with calcium only (control group). The thigh muscle volume was measured by quantitative CT. The bone mineral density of the hip, femur and tibia was assessed by quantitative CT and dual-energy x-ray absorptiometry and of the heel by quantitative ultrasound.

Quantitative CT showed that the anabolic group did not lose muscle volume during the first 12 months whereas the control group did (p< 0.01). There was less bone loss in the proximal tibia in the anabolic group than in the control group. The speed of gait and the Harris hip score were significantly better in the anabolic group after six and 12 months.

Anabolic steroids, even in this moderate dose, given in combination with vitamin D and calcium had a beneficial effect on muscle volume, bone mineral density and clinical function in this group of elderly women.