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Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 108 - 109
1 Mar 2009
Tzermiadianos M Hadjipavlou A Renner S Havey R Voronov M Zindrick M Patwardhan A
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Residual kyphotic deformity is considered the main factor for the increased risk of new fractures after an osteoporotic vertebral fracture. We hypothesized that even in the absence of kyphotic deformity, the altered pressure profile of the disc after a fracture will increase the risk for subsequent fractures.

Materials and Methods: Six fresh-frozen, human thoracolumbar specimens, consisting of 5 adjacent vertebrae, were used. A void was randomly created under the upper (n=3) or the lower (n=3) endplate of the middle vertebra. The specimen was then compressed in flexion until a selective fracture of the weakened endplate was observed. Vertebral kyphosis was reduced with extension. After cementation of the fracture, the rest of the trabecular content was evacuated and was filled with cement. Specimens were tested in flexion-extension (±6Nm) under 400N preload before and after the index fracture. Pressure was recorded at the discs above and below the fractured VB and strain at the anterior wall of the adjacent VBs. Finally, the specimen was loaded in flexion until a subsequent fracture was observed on fluoroscopy.

Results: In the intact specimens, nucleus pressure increased by 26.4±13.9% in full flexion compared to neutral posture. After the index fracture, the pressure in full flexion increased by 15.2±11 % in the discs with unfractured endplates, but decreased by 19±26.7% in the discs with the fractured endplate (p< 0.05). Anterior wall strain at the VB adjacent to the fractured endplate increased by 94.2%±22.8% (p=0.02), compared to an 18.2%±7.1% (p=0.98) increase at the VB adjacent to the unfractured endplate. Subsequent loading of the specimens after cementation of the index fracture resulted in a fracture of the adjacent VB close to the fractured endplate of the middle vertebra in 4 specimens and at the upper potted VB in one specimen. Maximum load applied with the actuators failed to create a fracture in one specimen.

Discussion: The effects of the fractured endplate were isolated by eliminating other known parameters. Vertebral kyphosis was reduced and cement was similarly distributed under both endplates.

In the intact specimens, nucleus pressure gradually increased during flexion. This can more evenly distribute the load during flexion to the entire surface of the endplate and avoid excessive load concentration to the anterior portion. After an endplate fracture, the nucleus pressure gradually decreased during flexion, meaning that the anterior annulus was forced to bear more load. This uneven load transfer to the anterior part of the VB resulted in doubling the strain at the VB adjacent to the fractured end plate. All adjacent factures were observed at the vertebra next to the damaged endplate. The altered mechanical behavior of the nucleus can be ascribed to the increased available space after the endplate depression.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 109 - 109
1 Mar 2009
Hadjipavlou A Tzermiadianos M Katonis P Gaitanis I Paskou D Kakavelakis K Patwardhan A
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The circulatory effects of multilevel balloon kyphoplasty (BK) are not adequately addressed, neither the effectiveness of egg shell cementoplasty in preventing anticipated cement leakage in difficult cases. The purpose of this study was to evaluate

the effect of multilevel BK to blood pressure and arterial blood gasses;

the incidence of methylmethacrylate cement leakage using routine postoperative computer tomography scan and

the effectiveness of egg shell cementoplasty to prevent cement leaks.

Materials and methods: This is a prospective study of 89 patients (215 vertebral bodies-VBs) with osteoporotic compressive fractures (OCF), and 27 with osteolytic tumors (OT) (88 VBs). The mean age was 67.6 years. 27 patients with OCF were treated at one level, 26 at two, 21 at three, 7 at four, 6 at five, and 2 at six levels at the same sitting. Three patients with OT were treated at one level, 6 at two, 9 at three, 3 at four, 4 at five, and 2 at seven. Egg shell balloon cementoplasty to prevent cement leakage was performed in 10 patients with severe endplate fracture or vertebral wall lytic destruction. Arterial blood pressure and oxygen saturation were monitored during surgery. Arterial blood gases were measured before and 3 min after cement injection. Cement leakage was assessed by the postoperative x rays and computer tomography scans.

Results: A drop in blood pressure of more than 25mmHg during cement injection was observed in 6 patients, and was not associated with the number of VB treated. Blood pressure was dropped more than 40mm in 2 patients and the procedure was aborted after completing 1 level in the first and 2 levels in the second. Drop in arterial O2 saturation was noted in 4 patients. One patient treated for 5 levels developed fever and tachepnoea for 24 hours after surgery. Arterial O2 and chest x-rays were normal. Cement leakage was found in 9.7% (21/215) of VBs treated for OCF. Its incidence per location was: epidural, 0.9% (2 VBs); intraforaminal, 0.5% (1 VB); intradiscal, 3.2% (7 VBs); and through anterior or lateral walls, 5.1% (11 VBs). In the OT group cement leakage was found in 10.2% (9/88) of the treated VBs. Its location included 8 (9%) through the anterior or lateral walls and one (1.1%) intradiscal. Cement leakage had no clinical consequences. No cement leakage was observed in cases treated with egg shell balloon cementoplasty.

Conclusions: BK is a safe procedure when applied for multiple levels in the same sitting, and its rare circulatory effects are not related to the number of levels treated. The incidence of cement leakage in this study was 10%, which is far less than that reported with vertebroplasty using routine postoperative CT scan. Egg shell balloon cementoplasty can effectively minimize cement leakage in cases with fractured endplate or lytic destruction of VB walls.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 133 - 133
1 Mar 2008
Hadjipavlou A Gaitanis I Tzermiadianos M Katonis P Pasku D
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Purpose: The purpose of this study is to evaluate the safety of methylmethacrylate cement balloon kypho-plasty (BK) when applied to five or six levels in the same sitting and the incidence and location of cement leakage.

Methods: Eighty nine patients (215 vertebral bodies-VBs) with osteoporotic compressive fractures (OCF), and 24 with osteolytic tumors (OT) (72 VBs) were treated with BK. Of patients with OCF, 27 were treated at one level, 26 at two, 21 at three, 7 at four, 6 at five, 2 at six levels. Of OT patients, 3 were treated at one level, 5 at two, 9 at three, 3 at four, and 4 at five.

Results: A drop in blood pressure of more than 25mmHg during cement injection was observed in four patients, and was not associated with the number of VB treated. The procedure was aborted in two patients. Otherwise no significant drop in arterial O2 was noted. One patient treated for 5 levels developed fever and tachepnoea for 24 hours after surgery. Arterial O2 and chest x-rays were normal. Pain significantly improved in 95% of patients with OCF and 98% of patients with tumors. In the osteoporotic group, kyphosis correction was achieved in 91% with a mean correction of 7.89°. Cement leakage occurred in 21/215 VBs (9.7%); Epidural: two (0.9%), intraforaminal: 1 (0.5%), intradiscal: 7 (3.2%) while through the anterior or lateral vertebral wall: 11 (5.1%). In the OT group leakage occurred in 6 VBs (8.3%), including 9 (7.0%) through the anterior or lateral wall and one (1.3%) intradiscal. None of the patients had any clinical consequences associated with cement leakage.

Conclusions: BK is a safe and effective procedure, even when applied for 5 or 6 levels. End plate fracture or vertebral wall lytic destruction can effectively be managed by eggshell balloon cementoplasty, thus minimizing the incidence of cement leakage. The incidence of cement leakage with KP (9.8%) is far less than that reported with vertebroplasty, (65.5% shown on CT scans).


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 1 | Pages 1 - 6
1 Jan 2008
Papadokostakis G Kontakis G Giannoudis P Hadjipavlou A

We have compared the outcomes of the use of external fixation devices for spanning or sparing the ankle joint in the treatment of fractures of the tibial plafond, focusing on the complications and the rates of healing. We have devised a scoring system for the quality of reporting of clinical outcomes, to determine the reliability of the results.

We conducted a search of publications in English between 1990 and 2006 using the Pubmed search engine. The key words used were pilon, pylon, plafond fractures, external fixation. A total of 15 articles, which included 465 fractures, were eligible for final evaluation.

There were no statistically significant differences between spanning and sparing fixation systems regarding the rates of infection, nonunion, and the time to union. Patients treated with spanning frames had significantly greater incidence of malunion compared with patients treated with sparing frames. In both groups, the outcome reporting score was very low; 60% of reports involving infection, nonunion or malunion scored 0 points.


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 4 | Pages 495 - 502
1 Apr 2007
Hadjipavlou A Tosounidis T Gaitanis I Kakavelakis K Katonis P

Vertebral haemangiomas are usually asymptomatic and discovered fortuitously during imaging. A small proportion may develop variable degrees of pain and neurological deficit. We prospectively studied six patients who underwent eight surgical procedures on 11 vertebral bodies. There were 11 balloon kyphoplasties, six lumbar and five thoracic. The mean follow-up was 22.3 months (12 to 36). The indications for operation were pain in four patients, severe back pain with Frankel grade C paraplegia from cord compression caused by soft-tissue extension from a thoracic vertebral haemangioma in one patient, and acute bleeding causing Frankel grade B paraplegia from an asymptomatic vascular haemangioma in one patient. In four patients the exhibited aggressive vascular features, and two showed lipomatous, non-aggressive, characteristics. One patient who underwent a unilateral balloon kyphoplasty developed a recurrence of symptoms from the non-treated side of the vertebral body which was managed by a further similar procedure.

Balloon kyphoplasty was carried out successfully and safely in all patients; four became asymptomatic and two showed considerable improvement. Neurological recovery occurred in all cases but bleeding was greater than normal. To avoid recurrence, complete obliteration of the lesion with bone cement is indicated. For acute bleeding balloon kyphoplasty should be combined with emergency decompressive laminectomy. For intraspinal extension with serious neurological deficit, a combination of balloon kyphoplasty with intralesional alcohol injection is effective.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 156 - 156
1 Mar 2006
Gaitanis L Gaitanis I Zindrick M Voronov L Paxinos O Hadjipavlou A Patwardhan A Lorenz M
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Purpose: A retrospective study comparing the fusion rate and, the incidence of junctional spinal stenosis between a rigid (Wiltse) and a semirigid (Varifix) posterior spinal fusion system.

Material & Methods: 92 patients, mean age 52.3 year old, underwent posterior fusion with semirigid Varifix system (rod diameter 5.0 mm), and 89 patients, mean age 49.8 year old, with rigid Wiltse system (6.5 mm). The mean follow-up was 4.8 years (range 2–9) for Varifix group and 11.7 years (range 9–17) for Wiltse group. Preoperative diagnosis was spinal stenosis (n=56), disc degenerative disease (n=43), degenerative spondylolisthesis (n=37), post-laminectomy instability (n=34), and isthmic spondylolisthesis (n=11). In all patients autologous iliac crest bone graft was used. Spinal fusion was confirmed by A-P, lateral, and flexion-extension radiographic studies, or by direct surgical exploration and observation. Pain intensity was recorded using the Visual Analogue Scale (VAS).

Results: Successful fusion was achieved in 92.4% in the semirigid group and in 93.2% for the rigid group. There was no statistical difference in fusion rate between these two groups (p=0.82). Eight patients with pseudoarthrosis were treated by anterior fusion and 5 by repaired posterior fusion, with a fusion rate of 100%. Postoperative infection was diagnosed in 5 patients (5.4%) in the semirigid group and in 4 patients (4.5%) in the rigid group. They were treated by debridement, irrigation, and intravenous antibiotics. Hardware removal because of pain was performed in 9 patients (9.8%) in the semirigid group, and 17 patients (19.1%) in rigid group. Removal of hardware resulted in improvement in pain in all patients. Junctional spinal stenosis was diagnosed in 2 patients (2.2%) in semirigid group and in 7 patients (7.9%) in rigid group. There was a trend for higher incidence of adjacent level stenosis in rigid group (p=0.07).

Conclusion: Biomechanical studies have shown that the stiffness of spinal construct depends on rod diameter and a decrease in rod rigidity can increase the risk of implant failure. In our study we didn’t find any difference in the fusion rate and in complication rate between these two systems. The increased percentage of the junctional spinal stenosis in rigid group may be explained by the longer follow-up in this group. According to our data the semirigid system may be better tolerated than the rigid system.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 150 - 150
1 Mar 2006
Gaitanis I Carandang G Ghanayem A Voronov L Phillips F Havey R Zindrick M Hadjipavlou A Patwardhan A
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Purpose: The purpose of this biomechanical study was to assess: (1) the effect of thoracic vertebral compression fracture (VCF) on kyphosis and physiologic compressive load path, and (2) the effect of balloon kyphoplasty and spinal extension on restoration of normal geometric and loading alignment.

Methods: Six fresh human thoracic specimens, each consisting of three adjacent vertebrae were used. In order to create a VCF, IBTs were placed transpedicularly into the middle VB and cancellous bone was disrupted by inflation of IBTs. After cancellous bone disruption the specimens were compressed using bilateral loading cables until a fracture was observed. Fracture reduction by spinal extension, and then by balloon kyphoplasty was performed under a physiologic compressive preload of 250 N. The vertebral body heights, kyphotic deformity, and location of compressive load path were measured on video-fluoroscopy images.

Results: The VCF caused anterior VB height loss of 3715%, middle-height loss of 3416%, segmental kyphosis increase of 147.0 degrees, and vertebral kyphosis increase of 135.5 degrees (p< 0.05). The compressive load path shifted anteriorly by 20% of A-P endplate width in the fractured and adjacent VBs (p=0.01). IBT inflation alone restored anterior VB height to 918.9%, middle-height to 9114%, and segmental kyphosis to within 5.65.9 degrees of pre-fracture values. The compressive load path returned posteriorly in all three VBs (p=0.00): the load path remained anterior to the pre-fracture location by 9–11% of the A-P endplate width. The extension moment fully restored the compressive load path to its pre-fracture location. Under this moment, the anterior and middle VB heights were restored to 858.6% and 749.4% of pre-fracture values, respectively. The segmental kyphosis was fully restored to its pre-fracture value; however, the middle height and kyphotic deformity of the fractured VB remained smaller than the pre-fracture values (p< 0.05).

Conclusions: An anterior shift of the compressive load path in VBs adjacent to VCF can induce additional flexion moments. The eccentric loading may contribute to the increased risk of new VB fractures adjacent to an uncorrected VCF deformity. Extension moment could fully correct the segmental kyphosis but could not restore the middle height of the fractured vertebral body. Balloon kyphoplasty reduced the VCF deformity and partially restored the compressive load path to normal alignment.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 286 - 287
1 Mar 2004
Hadjipavlou A Nader R Crow W VanSonnenberg E Nauta H
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Aims:This study: a)revisits the effectiveness of preoperative embolization alone for hypervascular lesions of the thoracolumbar spine and b) compares its action with intraoperative cryotherapy alone or in conjunction with embolization. Methods:14 patients underwent 15 surgeries for hypervascular spinal tumors. Ten of the surgeries were augmented by preoperative embolization alone. Four surgeries involved intraoperative cryocoagulation, and one surgery used a combination of preoperative embolization and intraoperative cryocoagulation for tumor resection. When cryocoagulation was used, its extend was controlled by intraoperative ultrasound or by establishing physical separation of the spinal cord from the tumor. Results:Among cases treated with embolization alone, 50% still had intraoperative blood-loss in excess of 3 liters. Mean blood-loss was of 2.8 liters/patient. One patient bled excessively (over 8000ml) terminating the surgery prematurely and resulted in suboptimal tumor resection. All procedures using cryo-coagulation achieved adequate hemostasis with average blood-loss of only 500 ml/patient by far better than embolization (P< 000.1). Conclusions:Preoperative embolization alone may not always be satisfactory for surgery of hypervascular tumors of the thoracolumbar spine. Although experience with cryocoagulation is limited, its use, with or without embolization, suggests its effectiveness in limiting blood-loss. Cryocoagulation may also assist resection by preventing tumor spillage, facilitating more radical excision of the tumor and enabling spinal reconstruction that eventually may contribute to improve survival. The extent of cryocoagulation could be controlled adequately with ultrasound. Somatosensory evoked potentials may provide early warning of cord cooling. No new neurological deþcits were attributable to the use of cryocoagulation.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 312 - 312
1 Mar 2004
Joseph C Kontakis G Katonis P Stergiopoulos K Hadjipavlou A
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Aims: In this study we assessed the results of the hemi-arthroplasty for shoulder fractures in patients with a follow-up 2 to 7 years. Methods: Twenty six patients (20 women and 6 men, mean age 64.7±8.2 years [range 41 to 78 years]), with a fracture of the upper humerus requiring hemiarthroplasty, were followed-up 2–7 years after surgery. Ten Coþeld, nine Global and seven Aequalis prosthesis were implanted, all cemented. All the procedures were performed 0–17 days after the injury (mean 5.5±4.6 days). The clinical outcome was assessed using the Constant-Murley scale. Results: The mean score, at their last follow up, was 70.4±16.4% (39–96%). The mean ßexion of the arm was 150û (30û–175û), the mean abduction was 145û (30û–170û), the mean external rotation was 30û (10û–45û) and the internal rotation corresponded with a position of the dorsum of the hand at the L3 vertebrae. The patients in our series achieved the optimum clinical result during the þrst 6 months after the operation. No statistical signiþcant improvement occurred after this period. Six months after the injury 20 out of the 26 patients (76.9%) had the same activity level as they had prior to the fracture. At their last follow up eighteen patients (69.2%) had no any pain and 7 (27%) patients had some mild pain at the end of their daily activities and 1 patient (3.8%) had pain even with mild activities. Conclusions: Shoulder hemiarthroplasty seems to be a worthwhile procedure in modern orthopaedic surgeonsñ armamentarium, giving predictable results presuming careful selection of the patients, restoration of the individual anatomy of the shoulder and aggressive rehabilitation program during the þrst 6 months after surgery.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 324 - 324
1 Mar 2004
Joseph C Kontakis G Katonis P Maris T Voloudaki A Hadjipavlou A
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Aims: The objective of this study was to assess whether anatomical placement of the prosthesis, in shoulder hemi-arthroplasty for fracture of the humeral head, is important to the clinical outcome. Methods: Sixteen patients, with a fracture of the upper humerus treated with hemi-arthroplasty, were followed-up 45.7±15.1 (20–72) months after surgery. The results were assessed using the Constant-Murley scale. The mean score was 75.8±15.7% (54–96%). At the time of their last follow up they underwent CT of the fractured and sound humerus, in order to be measured differences in humeral length and retroversion using special software. Correlation between these differences and the clinical outcome, as it was measured with the Constant-Murley scale, was performed. Results: The mean difference in retroversion was 8.7 degrees and the mean difference in length was 0.65cm, between fractured and sound humerus in our patients. We have achieved a very good þnal outcome (Constant score more than 71%) in patients with difference in retroversion less than 10 degrees and difference in length less then 14mm, between fractured and sound humerus. Conclusions: Restoration of the humeral length and retroversion is very important in shoulder hemiarthroplasty for fracture of the humeral head. Only small differences from the optimum length are well tolerated while only big differences from the optimum retroversion are likely to affect signiþcantly the clinical outcome. We attribute the very good clinical outcome in our series to the quality of the anatomical reconstruction that was performed despite the fact that our sample is small and we cannot have powerful statistics.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 370 - 371
1 Mar 2004
Hadjipavlou A Gaitanis I Crow W Lander P Katonis P Kontakis G
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Purpose: To describe the percutaneous transpedicular biopsy technique as a novel way of approaching lesion of the thoracic and lumbar spine, to determine the amount of bone retrievable through the pedicle and its diagnostic yield. Material and Methods: Seventy-nine patients underwent 84 biopsies. Seventy-seven procedures were performed with ßuoroscopic guidance arid seven with CT guidance. Seventy-one biopsies underwent under local anesthesia and ten under general anesthesia. Age range of patient was from 3 to 81 years. Results: Adequate specimens for correct diagnosis were obtained in 80 of the 84 patients with the following diagnoses. Pyogenic spondylodiscitis 31, tuberculosis 4, coccidiomycosis 2, echinococcus cyst 1, blastomycosis 1, brucella 4, primary neoplasm 7, metastatic neoplasms 16, osteoporotic fractures 8, osseous repair for insufþciency fractures 5, Pagetñs disease 1. The 4 negative biopsies subsequently proven to be Ç false negative È and were related to faulty biopsy techniques. Conclusion: Pitfalls can be avoided when adhering to the details of our technique. These pitfalls can occur while retrieving the instrumentation without simultaneous withdrawal of the guiding pin; crushing pathological soft tissue against sclerotic or normal bone; or when encountering a sclerotic lesion distal to normal bone without using a sequential type of biopsy specimen-retrieval technique. Any type of bleeding is controllable. The approach is a safe, efþcacious and cost effective and avoids so the problems such low diagnostic yield nerve root injury, pneumothorax and hematoma encountered with conventional needle technique


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 222 - 222
1 Mar 2003
Gaitanis I Tzermiadianos M Katonis P Thalassinos I Muffoletto A Hadjipavlou A
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Aim: Presentation of the application of the transcervical system of posterior spinal fusion Varigrip in spinal infections showing its rapid and safe application and also its stability to the spinal level where it is applied to.

Patients and Methods: 22 patients (13 men / 9 women) with mean age 50, 6 years (18–79) and mean follow up time is 34,6 months (9–62) were included in our study. In 10 patients the level was in lumbar spine and in 12 in thoracic spine. In their admission 16 patients had neurological deficit and 22 mean pain score according to VAS 8, 4 (6–10). ESR was increased in 14 patients, CRP in 20 and 7 patients had also increased WBC. All 22 patients had increased signal of Tc” and 69Ga in the level of the lesion and also pathological signal in MRI (Tl, T2 and Tl with Gadolinium). All the patients underwent posterior spinal fusion using Varigrip system and 17 of these underwent in the same time somatectomy and anterior fusion.

Results: Pathologic organism was isolated to all the patients. In 20 patients the tissue culture of the lesion isolated the pathologic organism and the other 2 patients came to us with positive blood cultures from other hospitals. 6 months postoperatively 21 patients referred pain score according to VAS 2,4 (1–4) and 1 patient had no improvement (5–7). 1 patient died of PE, another of chest infection and one of head injury. 1 patient had recurrence of the infection in another level, 1 had herpeszoster and 1 had infection of the surgical wound. All the patients had neurological improvement postoperatively.

Conclusions: The method is characterized as safe because of avoidance of the neurological structures. It can be applied also safely to patients with osteoporosis. Its application is rapid so the surgical time is minimum and also it doesn’t need image intensifier during the surgical procedure. It can be applied easily either in thoracic or lumbar spine and it provides stability of the spine.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 220 - 220
1 Mar 2003
Papadokostakis G Katonis P Gaitanis I Hadjipavlou A
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Aim: The aim of our study is to show if there is any relation between scoliosis in the lumbar spine and osteoporosis in postmenopausal women.

Materials and Methods: In 46 postmenopausal women who, according to WHO’s criteria (T-score < −2,5 ), had osteoporosis in lumbar spine and hip and in 40 post-menopausal women with established osteoporosis (T score < −2,5 and at least and vertebral fracture) was estimated clinical and radiological the presence or not scoliotic bow in the lumbar spine. The bone density was measured with DEXA method in the lumbar spine and in the hip and the scoliosis was measured radiologically with Cobb’s method. To all patients has been done full biochemical examination to exclude secondary osteoporosis cases. The radiological examination included face and lateral x-ray of the lumbar and thoracic spine and that was done to detect vertebral fractures and to exclude women with other degenerative lesions. Also were excluded from our study women with primary or metastatic tumors in the spine.

Results: Out of 46 women who had osteoporosis 32 (69%) had scoliotic lumbar bow and in 23 (50%) patients the bow was more than 10 degrees. Out of 40 women who had established osteoporosis 26 (65%) had scoliotic lumbar bow and in 22 patients (55%) the bow was more than 10 degrees. In contrast in the control group of 25 normal postmenopausal women 5 women (20%) had scoliotic lumbar bow and in 2 women (8%) the bow was more than 10 degrees. Also in the group with the 32 osteopenic women (34%) had scoliotic lumbar bow and in 8 women (25%) the bow was more than 10 degrees. Finally in the group of 32 postmenopausal women with degenerative lesions without osteoporosis 13 (31%) had scoliotic lumbar bow and only in 6 (18%) the bow was more than 10 degrees.

Conclusions: After the statistical analysis of the results is evident that postmenopausal women who have osteoporosis have also scoliosis in the lumbar spine.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 222 - 222
1 Mar 2003
Gaitanis I Katonis P Kakavelakis K Papadomihelakis K Hadjipavlou A
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Aim: Presentation of the technique, the mistakes and the results of a new minimal invasive surgical procedure for reduction and augmentation of pathological fractures of the vertebrae in spine.

Patients and Methods: 12 patients (2 men / 10 women) with mean age 68 years (54–73) with pathological vertebral underwent kyphoplasty. The mean pain according to VAS was 7, 3 (6–10) and the mean follow up time is 8 months (5–14). 11/12 patients (20 vertebrae) had osteoporotic vertebral and 1/12 (1 vertebra) had metastatic lesion. 8/21 vertebrae were in thoracic spine and 13/21 in lumbar spine. In 20/21 the procedure was transcervical to the vertebra and in 1/21 was out of the cervix. 11/12 patients had kyphotic deformity in the plain x-ray and 18/21 vertebrae had decreased their height. To all patients was spilled PMMA.

Results: 10/12 patients referred degrease of their pain in the first 48 hours and 2/12 in the 5th postoperative day. Correction of the kyphotic deformity was observed in 11/12 and reduction of the reduction of the fracture was occurred in 16/21 vertebrae. Leakage of PMMA was occurred in 5/21 vertebrae; in 2/5 the leakage was in the canal, in 1/5 in the intervertebral space and in 2/5 out of the vertebrae. 1/12 patient 2 moths postperatively had another vertebral fracture in a lower vertebra that was deled again with kyphoplasty. None of the patients had neurological deficit postoperatively. According to Oswestry questionnaire all the patients referred return to all their before fracture daily activities.

Conclusions: Kyphoplasty in pathological vertebral fractures has as a result the immediate decrease of the pain and the return of the patient to his/her daily activities. Also there is correction of the kyphotic deformity decreases the possibility of a new vertebral fracture and the establishment of chronic back pain.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 220 - 220
1 Mar 2003
Aligizakis A Katonis P Papoutsidakis A Galanakis I Stergiopoulos K Hadjipavlou A
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Aim: The purpose of this prospective study was to assess the functional outcome of conservative treatment with early ambulation of thoracolumbar burst spinal fractures, using the Load Shearing classification.

Material – Methods: From 1997 to 2001, 60 consecutive patients with single-level thoracolumbar spinal injury, with no neurological impairment, were classified according to the Load Shearing scoring and were managed non-operatively. A custom-made thoracolumbosacral orthosis was worn by all patients for six months, and early ambulation was recommended. Several radiological parameters were evaluated; the Denis Pain and Work Scale was used to assess the clinical outcome. The average follow-up period was 42 months (range, 24 to 55 months).

Results: During this period the spinal canal occupation was significantly reduced. Other radiological parameters, such as Cobb’s angle and anterior vertebral body compression, showed loss of fracture reduction, which was statistically insignificant. However, the functional outcome was satisfactory in 55 of 60 patients with no complications recorded on completion of treatment. Conclusions: Load Sharing scoring is a reliable and easy-to-use classification for the conservative treatment and prognosis of thoracolumbar spinal fractures. Because of the three characteristics of the fracture site this classification can also predict the structural results of the spinal injury, such as posttraumatic kyphosis, and thereby the functional outcome in conservatively treated patients.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 220 - 221
1 Mar 2003
Katonis P Thalassinos I Papoutsidakis A Alpantaki P Gaitanis I Hadjipavlou A
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Aim: The evaluation of the results of the posterior application of the combination of the implants Varifix (transcervical screws)/Varigrip (new generation under compression hook with middle line pedicle fixation) to the imstable thoracic and lumbar vertebral fractures.

Patients and Methods: During the years 1999–2001, 30 patients have been operated on with the combination of the implants Varifix/Varigrip to the unstable thoracic (T3–T10: 4), thoracolumbar (T11–L2:21) and lumbar (L3–L5:5) vertebral fractures. Mean age was 33, 5 years and sex variation was 22 men and 8 women. Road traffic accidents were the most common cause and the thoracic and lower limp injuries were the most common (17%) accompanied injuries. For the fracture type and the treatment indications the combination of Gertzbein & Gaines classification was used.

Results: The evaluation of the results was with radiological and clinical examination. Mean surgical time was 170 min (120–240) and the mean blood loss was 500ml (350–800). According to special questionnaire, 25 of the 30 patients (83, 5%) were free of pain and able to return to their previous activities. There was no deterioration in the 24 patients who were in Frankel E neurological condition and the mean post surgical improvement according to Frankel classification was 1, 4 points. In the radiological evaluation (compression percentage, Gardner ankle, conquest of the spinal canal) there was statistical significant difference (p < 0, 05, p < 0, 01, p < 0, 05) between pro and post surgical values. Two patients with acute infection were dealt with surgical cleaning, washing and closing of the wound in second time surgery. One failure of the hook in one patient with osteoporosis was dealt with removal of it.

Conclusions: TheVarifix/Varigrip combination has nearly the same surgical results with traditional partial implants. The satisfactory reduction during the operation in the 30 patients was preserved during the follow up time. The posterior Varigrip system acts with cross link splinting and provides multidirectional spinal stability when it is used alone or supporting the system Varifix for avoiding the detachment or break of the transcervical screws. We suggest the use of these systems for all the unstable thoracic and lumbar injuries because of their safe fixation and easy application.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 221 - 221
1 Mar 2003
Katonis P Muffoletto A Papadopoulos C Thalassinos I Hohlidakis S Hadjipavlou A
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Aim: Of Calveston (USA) and Crete (HELLAS). We studied immediate and long-term outcome of 50 patients who underwent subaxial lateral mass fixation of the cervical spine between January 1997 and March 2001.

Patients and Methods: Intraopeartive fluoroscopy and somatosensory evoked potential monitoring were employed in all patients. Immediate postoperative CT scans were performed to determine screw trajectory and placement. Follow up ranged from 1 to 5 years.

Results: Postoperative CT scans showed that 113 of 210 screws (54%) had unicorticate and 46% had bicorticate purchase. Forty-five screws (31 %) had suboptimal trajectory, but only 7 of these screws minimally penetrated the foramen transversarium without resultant vascular or neurological sequelae.

The overall fusion success rate in our series was 90%, while pseudoarthrosis occurred in 5 patients (10%), with screw breakage in 1 patient (2%). Two of these patients had bone graft supplementation and in other 2 patients was done anterior fusion.

Conclusions: Results of this study show that the recommended drilling technique and trajectory (15–25 degrees postal to the sagital plane, 20–30 degrees lateral I the axial plane), supplemented bone grafting and intraoperative SEP monitoring are all associated to good screw placement, fusion and neurological outcome and are recommended for all lateral mass fusion procedures.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 218 - 219
1 Mar 2003
Galanakis I Aligizakis A Katonis P Vavouranakis H Stergiopoulos K Hadjipavlou A
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Aim: The purpose of this prospective study was an evaluation of results in primary treatment of flexor tendon laceration in zone II. Special emphasis has been given to the postoperative rehabilitation program.

Material and Methods: Nineteen patients, (23 fingers), with laceration of the flexor tendons in zone II were treated operatively. Twelve males and seven females were included in the study. Their mean age was 28 (range, 16 to 50) years. In twelve cases a concomitant laceration of the digital nerve was present, hi all cases primary repair of all injured tendons and nerves was performed and a dorsal splint was applied. On third to fifth postoperative day an exercise program commenced involving passive flexion-active extension of the injured fingers. Eighteen (22 fingers) of 19 patients completed the follow-up.

Results: The results were estimated according to Strickland’s original classification system. In fifteen cases the result was excellent, in five good, and in two fair. Conclusions: After primary repair of injured flexor tendons, close follow-up, early protected motion and unrestricted motion of the interphalangeal joints affers the best chance of restoring optimal function to the hand.


The Journal of Bone & Joint Surgery British Volume
Vol. 68-B, Issue 3 | Pages 431 - 438
1 May 1986
Lander P Hadjipavlou A

A new dynamic classification of Paget's disease is proposed, incorporating both the radiographic phases of bone remodelling and the scintigraphic findings. Osteolytic, mixed and osteoblastic phases are associated with increased scintigraphic activity, while the osteosclerotic phase of remodelling is associated with normal or diminished activity and an osteoblastic radiographic appearance. Abnormal modelling of bone leading to deformity is produced by accelerated apposition or absorption at the periosteal and endosteal envelopes of the bone. In 112 patients with symptoms from Paget's disease, 527 lesions were classified. The most frequent remodelling phase was the mixed one and the most common modelling state was bone expansion with endosteal and periosteal apposition. Of 88 patients treated medically, 12 had lesions which progressed to increased bone formation without a change in modelling, and the active lesions in seven patients became inactive. Prolonged treatment with disodium etidronate led to progressive osteopenia in 11 patients.