Aims

Periprosthetic joint infections (PJIs) are rare, but represent a great burden for the patient. In addition, the incidence of methicillin-resistant Staphylococcus aureus (MRSA) is increasing. The aim of this rat experiment was therefore to compare the antibiotics commonly used in the treatment of PJIs caused by MRSA.

We report the kinematic and early clinical results of a patient- and observer-blinded randomised controlled trial in which CT scans were used to compare potential impingement-free range of movement (ROM) and acetabular component cover between patients treated with either the navigated ‘femur-first’ total hip arthroplasty (THA) method (n = 66; male/female 29/37, mean age 62.5 years; 50 to 74) or conventional THA (n = 69; male/female 35/34, mean age 62.9 years; 50 to 75). The Hip Osteoarthritis Outcome Score, the Harris hip score, the Euro-Qol-5D and the Mancuso THA patient expectations score were assessed at six weeks, six months and one year after surgery. A total of 48 of the patients (84%) in the navigated ‘femur-first’ group and 43 (65%) in the conventional group reached all the desirable potential ROM boundaries without prosthetic impingement for activities of daily living (ADL) in flexion, extension, abduction, adduction and rotation (p = 0.016). Acetabular component cover and surface contact with the host bone were > 87% in both groups. There was a significant difference between the navigated and the conventional groups’ Harris hip scores six weeks after surgery (p = 0.010). There were no significant differences with respect to any clinical outcome at six months and one year of follow-up. The navigated ‘femur-first’ technique improves the potential ROM for ADL without prosthetic impingement, although there was no observed clinical difference between the two treatment groups.

Cite this article: Bone Joint J 2015; 97-B:890–8.

Femoral stem version has a major influence on impingement and early post-operative stability after total hip arthroplasty (THA).

The main objective of this study was to evaluate the validity of a novel radiological method for measuring stem version. Anteroposterior (AP) radiographs and three-dimensional CT scans were obtained for 115 patients (female/male 63/72, mean age 62.5 years (50 to 75)) who had undergone minimally invasive, cementless THA. Stem version was calculated from the AP hip radiograph by rotation-based change in the projected prosthetic neck–shaft (NSA*) angle using the mathematical formula ST = arcos [tan (NSA*) / tan (135)]. We used two independent observers who repeated the analysis after a six-week interval. Radiological measurements were compared with 3D-CT measurements by an independent, blinded external institute.

We found a mean difference of 1.2° (sd 6.2) between radiological and 3D-CT measurements of stem version. The correlation between the mean radiological and 3D-CT stem torsion was r = 0.88 (p < 0.001). The intra- (intraclass correlation coefficient ≥ 0.94) and inter-observer agreement (mean concordance correlation coefficient = 0.87) for the radiological measurements were excellent.

We found that femoral tilt was associated with the mean radiological measurement error (r = 0.22, p = 0.02).

The projected neck–shaft angle is a reliable method for measuring stem version on AP radiographs of the hip after a THA. However, a highly standardised radiological technique is required for its precise measurement.

Cite this article: Bone Joint J 2015; 97-B:306–11.

There is a complex interaction among acetabular component position and the orientation of the femoral component in determining the maximum, impingement-free prosthetic range of motion (ROM) in total hip arthroplasty (THA). Regarding restrictions in ROM, femoral antetorsion is one of the most important parameters. But, ROM is also influenced by parameters like the deviation between the femoral shaft and the mechanical axis in a sagittal projection. This deviation is best described as “Femoral Tilt” (FT). This study analysis the incidence of FT in clinical practice and its consequences on post-operative ROM. Based on these results, the effects of changes in FT on ROM-based cup optimisation are assessed by a using a virtual ROM analysis.

For studying the incidence of FT, 40 (16 male, 24 female) postoperative computerised tomography (CT) scans were analysed using a 3D CT planning software. The implant models were superimposed onto the image data to determine their exact position. The anatomical orientations were determined by planning anatomical landmarks and coordinate directions (i.e. mechanical axis, posterior condyle axis). Descriptive statistics were calculated for FT. Effects of changes in FT and CCD on ROM were analysed by calculating zones of compliance. FT was varied between 2.1° and 9.3° for 135°.

The overall range of post-operative values for femoral tilt was 5.7° ± 1.8° (mean ± standard deviation, minimum 1.7°, maximum 10.2°). The zone of compliance significantly depended on FT (difference more than 200%). The optimum cup position changed from 35° radiographic inclination/30° anteversion to 39°/30° when FT was increased from 2.1° to 9.3°.

Within this study, it was demonstrated that FT has a significant effect on postoperative ROM in THAs. First of all, it was shown that clinically FT values lie in a range between 2.1° and 9.3° (95% CI), where we used a long-shaft stem type with a relatively low possibility to influence sagittal tilt angles. FT may significantly change zones of compliance up to 200% as well as optimised cup positions. Thus, standard combined anteversion formulas, which were proposed in the literature to implement femur first approaches for THA, do only particularly address an optimisation of post-operative ROM. Instead, a sophisticated virtual ROM analysis based on a navigated femur-first approach would enable accurate ROM estimations as parameters like FT are hard to be assessed intra-operatively.

Background

For some time, optimized perioperative pathway protocols have been implemented in orthopedic surgery. In our hospital an accelerated clinical pathway has been successfully in effect for several years, focused on safely decreasing patients' length of stay and increasing their function at the time of discharge. The aim of the present project was to evaluate whether a further optimization is even more promising regarding early postoperative outcome parameters.

Orientation of the native acetabular plane as defined by the transverse acetabular ligament (TAL) and the posterior labrum was measured intra-operatively using computer-assisted navigation in 39 hips. In order to assess the influence of alignment on impingement, the range of movement was calculated for that defined by the TAL and the posterior labrum and compared with a standard acetabular component position (abduction 45°/anteversion 15°).

With respect to the registration of the plane defined by the TAL and the posterior labrum, there was moderate interobserver agreement (r = 0.64, p < 0.001) and intra-observer reproducibility (r = 0.73, p < 0.001). The mean acetabular component orientation achieved was abduction of 41° (32° to 51°) and anteversion of 18° (−1° to 36°). With respect to the Lewinnek safe zone (abduction 40° ±10°, anteversion 15° ±10°), 35 of the 39 acetabular components were within this zone. However, there was no improvement in the range of movement (p = 0.94) and no significant difference in impingement (p = 0.085).

Alignment of the acetabular component with the TAL and the posterior labrum might reduce the variability of acetabular component placement in total hip replacement. However, there is only a moderate interobserver agreement and intra-observer reliability in the alignment of the acetabular component using the TAL and the posterior labrum. No reduction in impingement was found when the acetabular component was aligned with the TAL and the posterior labrum, compared with a standard acetabular component position.

Introduction: Osteochondral lesions of the talus (OCL III–IV°) need both extensive debridement for revitalisation and osteochondral reconstruction of the joint surface. This can be achieved by autologous cancellous bone-grafting and combination with a cell-free bioresorbable collagen-I/III scaffold. Our first results with this technique are presented.

Methods: 25 patients (13 female, 12 male, mean age 30.9 years) with 26 osteochondral lesions of the talus (OCL III–IV°, 15 right, 11 left, 24 medial, 2 lateral, 1 bilateral case) were treated by minimal-invasive debridement, autologous cancellous bone-grafting and application of a porcine collagen-I/III scaffold (ChondroGide^®) and evaluated prospectively by clinical scoring and MRI. The average follow-up was 23.2 (6–36) months. The mean defect size was 2.0 cm², the mean depth 0.7 cm. 14 defects have had at least one (1–3) operation on the defect before. By the use of a distractor a malleolar osteotomy could be avoided in all cases.

Results: The AOFAS-score increased from 67.4 ± 12.2 to 89.5 ± 7.4 points (p< 0.01, t-test). On a visual 10-point scale pain decreased significantly from 6.2 to 1.7 while subjective ankle function improved from a mean of 4.4 ± 1.9 to 7.2 ±1.5. The results were rated excellent in 10/26 cases (38.4%), good in 14/26 (53.8) and fair in 2/26 (7.8%) cases. MRI follow-ups showed a complete or nearly complete defect filling. In two ankles a second-look arthroscopy unveiled the defects filled completely by a regenerative tissue with a smooth surface and good bonding. Full-core biopsies showed a mixed, mostly fibrocartilagenous tissue.

Conclusion: By combination of cancellous bone-grafting with a cell-free collagen-I/III scaffold typical osteochondral lesions of the talus can be adressed effectively in a minimal-invasive one-step procedure. By utilizing mesenchymal stem cells (MSC) for an autogenous reparation process the use of expensive cultured chondrocytes is not necessary. The results concerning clinical functional improvement, pain reduction and patients’ satisfaction as well as defect filling in MRI are promising.

Introduction: Revitalizing of the necrotic subchondral bone is the therapeutic paradigm in OCL/OD of the talus. Bone-marrow stimulation includes K-wire drilling or open debridement and cancellous bone grafting. Our results presented here are based on retrograde core-drilling and autologous cancellous bone-grafting of the talar dome guided by fluoroscopy and arthroscopy. Performed as a minimal-invasive technique, no additional harvesting site for bone-grafting is necessary.

Methods: 38 patients (16 female, 25 male) with 41 symptomatic focal osteochondral lesions (ICRS I–III°) of the talus (3 bilateral) were treated by fluoroscopicguided retrograde coredrilling and autologous cancellous bone-grafting from the drilling cylinder. The results were evaluated retrospectively by use of the Ogilvie-Harris-Score (OHS), subjective clinical ratings on a visual analogue scale (VAS (0–10 max.)) and MRI. The patient’s mean age was 33.2 (±15.4) years. 27 patients (66%) reported a trauma history (sprain, compression). Most defects were located in the medial talus (36/41), 4 were lateral and 1 central. 34 cases were primary interventions. In 14 cases the growth plate of the distal tibial epiphysis was detectable.

Results: The follow-up was 7–54 months with a mean of 29 (±13) months. The arthroscopic findings according to ICRS classified 12/41 as I°, 22/41 as II° and 7/41 as III° lesions. Preoperatively there were 11 poor, 25 fair, 4 good and 1 excellent ratings in the OHS-score turning into 1/9/13/18 postoperatively. There were 75.6% (31/41) overall good/excellent results. Good or excellent results were predominantly seen in grade I with 91.6% (11/12) and in grade II with 77.3% (17/22), whereas grade III showed success only in 42.8% (3/7). Open growth plates resulted good or excellent results in 85.7% (12/14 cases). First-line treatments showed a markedly better outcome of 82.3% (28/34) of good/ excellent results compared to 42.8% (3/7) of second-line treatments. Gender or trauma history did not influence the score results. Pain intensity on a VAS significantly reduced from 7.5 (±1.5) to 3.7 (±2.6). The subjective functional status on the VAS revealed a remarkable increase from 4.6 (±2.3) to 8.2 (±2.0), (p< 0.01). In MRI controls two patients showed a progression into demarcation (IV°) associated with a fair or poor score result.

Conclusion: Our results indicate that fluoroscopic-guided retrograde core-drilling and autologous cancellous bone grafting is an appropriate operative option for talar OCL in minor grades I + II. Performed as a minimal-invasive technique, the subchondral necrosectomy and combined bone-grafting provide extended revitalization properties for OCL healing. Tending to success rates of only 42% in lesions III°, this technique can not generally be recommended here.

In a prospective and randomised clinical study, acetabular cups were implanted free-hand (control group n=25) or with computer assistance using an image-free navigation system (study group n=25). Total hip replacement was performed in lateral position and through minimally invasive anterior approach (MicroHip). The cup position was measured postoperatively on pelvic CT using the CT-planning software.

An average inclination of 42.3° (range: 35°–56°; SD±8.0°) and an average anteversion of 24.0° (range: −5° to 54°; SD±16.0°) were found in the control group, and an average inclination of 45.0° (range: 40°–50°; SD±2.8°) and an average anteversion of 14.4° (range: 5°–25°; SS±5.0°) in the computer-assisted study group. The deviations from the desired cup position (45° inclination, 15° anteversion) were significantly lower in the computer-assisted study group (p< 0.001 each). While only 10/25 of the cups in the control group were within the Lewinnek safe zone, 18/25 of the cups in the study group were placed in this target region (p=0.003). We saw no disadvantage compared to previous studies in supine position with standard approach.

Introduction: Restoration of neutral alignment of the leg is an important factor affecting the long-term results of total knee arthroplasty (TKA). Recent developments in computer-assisted surgery have focused on systems for improving TKA. To verify that computer assistance improves the leg alignment and the component orientation, we present a single center study with 1000 patients.

Materials and Methods: In a prospective study two groups of 500 patients each undergoing TKA had operations using either a computer-assisted image free navigation system or a conventional technique. Alignment of the leg and the orientation of components were determined on post-operative long-leg coronal and lateral films.

Results: The mechanical axis of the leg was significantly better in the computer-assisted group (97%, within ±3° varus/valgus) compared with the conventional group (78,5%, within ±3° varus/valgus). The coronal alignment of the femoral component was also more accurate in the computer-assisted group.

Discussion: Computer-assisted TKA gives a better correction of alignment of the leg and orientation of the components compared with the conventional technique. Potential benefits in the long-term outcome and functional improvement require further investigation.

Soft tissue management is a critical factor in total knee arthroplasty especially in valgus knees. The stepwise release has been based upon surgeon’s experience until now. Computer assisted surgery gained increasing scientific interest in recent times and allows the intraoperative measurement of leg axis and gap size in extension and flexion.

We therefore aimed to analyse the effect of the sequential lateral soft tissue release and the resulting change in the a.p. limb axis on the one hand and the tibiofemoral gaps on the other hand as well in extension as in flexion in 8 cadaveric knees. Measurements were obtained using a CT-free navigation system.

In extension the highest increase compared to the previous release step was found for the first (iliotibial band, p=0.002), second (popliteus muscle, p=0.0003), third (LCL, 0.007) and the sixth (entire PCL, p=0.001) release step. In 90° flexion all differences of the lateral release steps were statistically significant (p< 0.004). Massive progression of the lateral gap in flexion was found after the second (popliteus muscle, p=0.004) and third (LCL, 0.007) release step.

Computer assisted surgery allows to measure the effect of each release step of the sequential lateral release sequence and helps the surgeon to asses the result better.

Abstract: Although the unconstrained pyrocarbon prosthesis (Ascension®) has been presented as a new alternative in the treatment of idiopathic arthritis of the proximal interphalangeal joint of the hand a few years ago, there is still a lack of studies analyzing the results of this implant.

In this study 10 patients (13 implants), that were tretated with this type of prosthesis between february 2002 and january 2005 were studied. All but one patient were satisfied with the postoperative situation and would agree to another operation.

A significant pain reduction was observed. The average ROM was 58degrees. Five patients demonstrated a free extension, two patients had a swan neck defomity, which could be actively compensated for, and the remaining six patients had an extension deficit of 30–45degrees. The average flexion was 76° (+/−12°).

X-ray examination was unremarkable in eight patients with a regular position of the endoprosthesis. However, in five patients significant radiolucent lines (> = 1mm) were observed. So far, a luxation of the prosthesis has not occurred and all implants are still in-situ. However, a dorsal tenoarthrolysis had to be performed in 3 patients.

The results of this study show a high rate of patient satisfaction with a significant pain reduction. The radiological results have to be closely monitored in the future.

Long-term results with a higher number of patients are necessary. A central registry for finger implants is recommended.

Introduction: Bone-marrow stimulating techniques like microfracturing for focal chondral defects of the knee joint are widespread utilizing mesenchymal stem cells (MSC) for an autogenous reparation process. Microfracturing shows good results for smaller defects up to 2cm² while larger defects tend to an early secondary degeneration. Autologous Matrix Induced Chondrogenesis (AMIC®) combines microfracturing with application of a porcine collagen type-I/III bilayer matrix to host the MSC and to stabilize the blood clot.

Methods: 32 patients (25m, 7f, mean age 37.4y (18–52y)) with 35 focal chondral defects of the knee joint (ICRS III–IV°) of the condyle, trochlea and/or patella were treated by standardized microfracturing and application of a collagen matrix (Geistlich Biomaterials, Wolhusen, Switzerland). The outcome was evaluated prospectively by clinical scores and MRI with a follow-up of 6 to 24 months. The mean defect size was 3.86 cm² (1.0 – 6.8 cm²). 22 patients (68%) had at least one operation (1–8) on the knee before. 9 defects were caused by trauma. All 7 patients with osteochondritis dissecans had an autologous bone grafting. In 5 patients an ACL stabilization was performed simultaneously.

Results: All patients considered their knee as abnormal (ICRS III° (70%)) or severely abnormal (ICRS IV° (30%)) preoperatively according to the ICRS functional status. The Cincinnati-Score improved from 52.9 to 81.1 points while the Lysholm-Score rose from 60.4 to 85.9 points (each p< 0.001). Pain decreased significantly from 6.1 to 2.2 (10=max.) on the visual analogue scale. 4 biopsies (4–21 months) revealed reasonable results with regard to surface formation, filling and integration in the Brittberg score (∅10.25 pts., 12 pts.=max.) The MRI follow-ups showed an adequate filling of the defect, no prolonged effusion occured.

Conclusion: Microfracturing in combination with a collagen matrix (AMIC®) is a minimal invasive, effective technique for the repair of focal cartilage defects of the knee joint. Not using cultured chondrocytes it can be performed cost-effectively as a single-step procedure. Both primary and secondary treatments are possible. The first results concerning clinical functional improvement, pain reduction and patients’ satisfaction as well as defect filling in MRI are promising.

AIM: Total hip replacement is the most successful procedure since 3 decades. In the last years a lot of new helpful implants were introduced to the market, minimal invasive procedures are presented in increasing numbers and the technique of navigation is introduced. On the other hand there is no scientific proof of the benefit of these procedures. The objective of this study was to collect data about the different procedures and the common used implants.

METHOD: In a countrywide anonymous survey, 250 German trauma surgery and orthopaedic surgery departments were asked about their MIS procedures and their treatment strategies.(August 2006)

RESULTS: 112 of the questionnaires have been returned so far. We found 82% of the surgeons doing minimal invasive THR, 18% are doing more than 50% of all procedures in MIS technique, while 45% of the colleagues report, that the patients never ask for the procedure. Most of the surgeons (58%) define “minimal invasive” as the preservation of muscle, tendons and soft tissue, 1% as the preservation of bone and 41% as the length of skin incision (6–12cm). The most common MIS approach is the lateral (45%), followed by the anterior approach (25%) and the modified Watson-Jones approach (21%) and the MIS dorsal approach (19%) (Some use more than 1 approach). For standard procedure (not minimal invasive) there is most used the Kocher approach (51%), followed by Bauer approach (29%) and Smith-Petersen/Watson-Jones (19%). 23% use navigation and 51% are convinced, there is no sense in that.

66% do not use articular resurfacing, 33% are using short implants.

CONCLUSION: While the technique of MIS in THR is whidespread in Germany, an exact definition is still missing. Patients don’t expect MIS as much as surgeons perform it. Out of the variety of approaches a standard still has to be defined.

For minimal invasive procedure there is most used a lateral approach, for standard procedure the Kocher approach. New implants are used by every third surgeon, navigation by every fourth surgeon.

Introduction: Previous reports have described the potentially compromising effect of a high tibial osteotomy (HTO) on the results of a subsequent total knee arthroplasty (TKA). Although the reasons are not clear, some authors reported of problems in soft tissue balancing in TKA following a previous HTO.

Method: In a prospective study 22 patients with an average interval of 5.8 years after closed wedge HTO, were operated for TKA. All surgeries were performed with the BrainLAB CT-free navigation system and measurements of the extension and flexion gap were assessed. The intraoperative data were compared to a control group of 100 consecutive computer assisted TKA without previous HTO.

Results: In the study group a highly significant shift towards a medial opening of the flexion gap between the posterior condylar line and the tibial resection (study group 0.4° +/− 4.7° medial opening vs. control group 3.4° +/− 3.3° lateral opening, p< 0.001) was observed. 45% in the study group showed a medial opening of the flexion gap compared to 11% in the control group.

Conclusion: Surgeons should be aware of difficulties in soft-tissue balance in TKA following HTO, especially for the flexion gap configuration and the axial femoral component orientation. The computer assisted technique is helpful to identify soft tissue imbalance.

Introduction Correct postoperative leg alignment and stability of total knee prothesis over the full range of movement is one critical factor for successful TKA. This can only be achieved by correct implantation of prothesis and soft tissue handling. Still arthrotomy, surgical approach and handling of patella are discussed controversially.

Materials and Methods In a cadaver specimen study we evaluated the influence of everted or subluxated patella on limb axis during balancing of the knee in three different standard surgical approaches. For each approach we operated five knees. Leg alignment was visualised by Ci CT-free DePuy/BrainLAB navigation system. First, physiological leg alignment was measured. Then the different approaches were performed and a.p. leg axis was first measured and compared as well with everted as with subluxed patella in extension and second in 90 degrees flexion.

Results Eversion of patella leads to an alteration in leg axis compared to subluxed patella of 0.58 degrees (SD: 0.03, range: 0.54–0.6) limb axis in valgus direction in full extension. In 90 degrees flexion we found a mean deviation of leg axis of 0.48 degrees (SD: 0.11, range: 0.38–0.6) with everted patella compared to subluxed patella.

Discussion The surgeon has to be aware of this falsifying influence of everted patella to the a.p. limb axis.

In a prospective randomised clinical study acetabular components were implanted either freehand (n = 30) or using CT-based (n = 30) or imageless navigation (n = 30). The position of the component was determined post-operatively on CT scans of the pelvis.

Following conventional freehand placement of the acetabular component, only 14 of the 30 were within the safe zone as defined by Lewinnek et al (40° inclination sd 10°; 15° anteversion sd 10°). After computer-assisted navigation 25 of 30 acetabular components (CT-based) and 28 of 30 components (imageless) were positioned within this limit (overall p < 0.001). No significant differences were observed between CT-based and imageless navigation (p = 0.23); both showed a significant reduction in variation of the position of the acetabular component compared with conventional freehand arthroplasty (p < 0.001). The duration of the operation was increased by eight minutes with imageless and by 17 minutes with CT-based navigation.

Imageless navigation proved as reliable as that using CT in positioning the acetabular component.

Restoration of neutral alignment of the leg is an important factor affecting the long-term results of total knee arthroplasty (TKA). Recent developments in computer-assisted surgery have focused on systems for improving TKA.

In a prospective study two groups of 80 patients undergoing TKA had operations using either a computer-assisted navigation system or a conventional technique. Alignment of the leg and the orientation of components were determined on post-operative long-leg coronal and lateral films.

The mechanical axis of the leg was significantly better in the computer-assisted group (96%, within ±3° varus/valgus) compared with the conventional group (78%, within ±3° varus/valgus). The coronal alignment of the femoral component was also more accurate in the computer-assisted group.

Computer-assisted TKA gives a better correction of alignment of the leg and orientation of the components compared with the conventional technique. Potential benefits in the long-term outcome and functional improvement require further investigation.