Introduction: Surgical treatment options of malignant tumors of the pelvis were traditionally very limited, and often resulted in an amputation. With development of neo/-adjuvant therapies, limb-salvage surgery has become the treatment of choice. Still, the treatment remains challenging, and options for pelvic reconstruction after resection such as allografts, radiated autografts, saddle-prosthesis, custom made prosthesis and modular reconstruction systems are all associated with high complication rates. Aim of our retrospective study was to evaluate the results after reconstruction of the pelvis with a custom-made pelvic megaprosthesis.

Materials and Methods: From 1977 to 2008, a total of 92 patients with malignant tumors or metastases of the pelvis were treated by resection and reconstruction with custom-made pelvic megaprostheses at our institution. Mean age was 56.2 years [17–77] with 43 male patients and 59 female. We treated 45 primary tumors and 47 metastases. Primary tumors included chondrosarcoma (45,4%), Ewing’s sarcoma (18,2%), malignant fibrous histiocytoma (9,1%), osteosarcoma (4,5%) and others. In the group with metastases we found renal cell carcinoma (52,4%), mamma-carcinoma (14,3%), thyroid carcinoma (9,5%), oropharyngeal carcinomas (9,5%), and others. Wide resection was performed in 11 patients, marginal-resection in 47, and intralesional-resection in 34 patients. Depending on the bone defect after tumor resection, pelvic megaprostheses were implanted either in the superior part of the iliac wing, the sacrum and/or the lower lumbar spine.

Results: Patients were reassessed repeatedly at two different time points resulting in a mean follow-up of 3,6 years [range 0,5 to 8,4years]. A total of 55 patients were available for follow-up, 29 had died and 6 Patients were not available for evalutation (living abroad). In the group with malignant tumors 50% of the patients were alive after 5 years; 50% of patients with metastasis survived at least 2 years. The local recurrence rate was 15%. In 2 of these patients local re-resection was possible, and 5 patients were treated with secondary external hemi-pelvectomy. Aseptic failure of the megaprosthesis was observed in 3%. The MSTS-Score showed good results in 34%, fair results in 42% and poor results in 23%. We found infections in 14%. Nerve palsy occurred in 11%, thombosis in 5%, and dislocation of the prosthesis in 15% of patients.

Discussion: Our study demonstrates that reconstruction of pelvic bone defects after tumor resection with custom-made megaprosthesis allows limb-salvage surgery with satisfying functional results. In spite of the relatively high complication rates-which are comparable or even favorable to other reconstruction techniques-we consider the custom-made megaprosthesis our treatment of choice to reconstruct pelvic bone defects.

Background: A total hip arthroplasty system with 3-dimensional interconnecting surface topography was developed for optimum osseous integration and long term stability. The present study was performed to assess long-term implant survival and function.

Methods: We prospectively studied a consecutive series of 100 cementless total hip arthroplasties in 94 patients using the ESKA GHE cementless spongy metal hip replacement. Study end-point was implant revision, and both function as well as satisfaction with treatment outcome was assessed after a mean follow-up of 18 years.

Results: Mean age at the time of operation was 47 years [range 18–65]. Seven patients were lost to follow-up. 11 patients had died for unrelated reasons at 14.1 ± 4.3 years after surgery with all 14 hip replacements in situ. Consequently, at a mean follow-up of 18 years [15.3 – 20.3], 74 patients (74 hips) could be included in the final analysis. Survival with aseptic loosening as the endpoint was 95% for the femoral component and 85% for the acetabular component. Two cups had to be revised for recurrent dislocation, resulting in a total implant survival at follow-up of 95% for the femoral component and 81% for the acetabular component.

Very good functional results were obtained with an improvement of the mean Merle d’Aubigné score from 9.5 ± 2.0 at baseline to 15.0 ± 3.1 at follow-up, and 86% excellent or good results (McNab score). Satisfaction with treatment outcome was high, and 96% of patients would recommend the performed procedure to a friend.

Conclusion: Excellent survival rates were observed in a young patient population after cementless hip arthroplasty with the GHE spongy metal hip replacement at a mean follow-up of eighteen years. Thus, modern cementless hip replacement shows long-term survival and might be favourable in young and active patients.

Sclerosing epitheloid fibrosarcoma (SEF) is an extremely rare soft tissue sarcoma arising from connective tissue cells of mesenchymal origin. SEF mostly occurs in extraosseous sites in the soft tissue; however two cases of primary localization in the bone have been described. Despite benign cytological features the clinical course is complicated by a high local recurrence rate and late metastases. SEF represents a clinically challenging entity especially because no standardized treatment regimens are available.

We report a 16-year old female patient who showed persistent load-dependent pain focused on the right proximal tibia. Radiological evaluation revealed an osteolytic lesion and the diagnosis of a benign bone cyst was consented. The tumor was surgically removed. Only after recurrence of the tumor and repeated histopathological analysis diagnosis of SEF could be established.

Because of the bone localization of the tumor the patient underwent standardized neoadjuvant chemotherapy analogous to the European-American EURAMOS-1 protocol for the treatment of osteosarcoma followed by tumor resection and endoprothesis. Histopathological analysis of the resected tumor showed > 90% vital tumor cells suggesting no response to the neoadjuvant chemotherapy. Therefore, therapy was reassigned to the CWS protocol of the German Society for Pediatric Oncology and Hematology (GPOH) for treatment of soft tissue sarcoma. To date, the patient is alive and no metastases of the primary tumor can be detected.

SEF represents a taunting clinical entity due to deceptive histopathological features and rare occurrence. Localization in the bone represents an additional challenge with regards to the therapeutical approach. Standardized treatment regimens are currently not available for SEF. This case report, to our knowledge, is the first outlining a therapeutic approach in detail. Our data suggest that SEF may be resistant to a chemotherapy regimen containing Cisplatin, Doxorubicin and Metho-trexate despite close association to the bone, possibly indicative of the soft tissue histogenesis of this tumor. The response to the soft tissue sarcoma targeting CWS chemotherapy remains to be determined.

Goal: Evaluation of prognostic factors on the long term survival of soft tissue sarcomas after resection.

Methods: Between 1991–2003

a) 29 synovial sarcomas males:femals 15:14 (mean age 36),

R0 resection was archived by 71% of the synovialsarcomas, 60% of leiomyosarcomas and 73% of MFHs’. The histological garding of synovialsarcomas was: G1: 0%, G2:21%, G3:73% and Gx: 6%. The histological garding of leiomyosarcomas was: G1:7%, G2:20%, G3:73% with 11 primary recurrences and the grading of the MFHs’ was G1: 7,7%, G2: 15,4%, G3: 69,2% und Gx: 7,7%.

Results:

Synovial sarcomas:

After a follow-up of 8 (2–14) years the overall survival was 57%, after R0-resection 65% and after R1 resection 0%. The survival of G2 und G3 was 67% and 53% respectively. The survival of T1 and T2-tumors was 100% and 39% respectively. The 2- and 4 year survival of patients with primary metastases and local recurrence was 50% und 28%. 55% of the patients developed local recurrence.

Scores for function and quality of life after treatment were 79% (37%–100%) for synovial- and 76% (53%–93%) for leiomyosarcomas and 76% (44%–100%) for MFHs

Conclusions: The investigated soft tissue sarcomas are highly malignant tumors. Bad prognostic factors for reduced long term survival are T2-tumors and G3-tumors (except MFHs’), local recurrence, metastases at the time of diagnosis and tumors after R1-resection, requiring aggressive multimodal treatment with chemotherapy, radiation and wide or even radical surgery.

Osteochondrosis juvenilis is caused by a dysfunction of endochondral ossification. Several epiphyses and apophyses can be affected, but osteochondrosis juvenilis of the medial malleolus has not been reported. We describe a 12-year-old boy with bilateral pes planovalgus who was affected by this condition. Conservative management was successful. The presentation, aetiology and treatment are described and the importance of including it in the differential diagnosis is discussed.

In orthopedic surgery, sterilization of bone used for reconstruction of osteoarticular defects caused by malignant tumors is carried out in different ways. At present, to devitalize tumor-bearing osteochondral segments, mainly extracorporal irradiation or autoclaving is used. Both methods have substantial disadvantages, e.g. loss of biomechanical and biological integrity of the bone. In particular integration at the autograft-host junction after reimplantation is often impaired due to alterations of the osteoinductivity following irradiation or autoclaving. As an alternative approach, high hydrostatic pressure (HHP) treatment of bone is a new technology, now being used in preclinical testing to inactivate tumor cells without alteration of biomechanical properties of bone, cartilage and tendons. The aim of this study was to investigate the influence of HHP on fibronectin (FN), vitronectin (VN), and type I collagen (col. I) as major extracellular matrix proteins of bone tissue, accountable among others for the osteoinductive properties of bone.

Fibronectin, vitronectin and type I collagen were subjected to HHP (300 and 600 MPa) prior to the coating of cell culture plates with these pre-treated proteins. Following the biological properties were measured by means of cell proliferation, adherence, and spreading of the human osteosarcoma cell line (Saos-2) and primary human osteoblast-like cells.

Up to 600 MPa all tested matrix proteins did not show any changes, regarding the biological properties adherence, spreading and proliferation.

We anticipate that, in orthopedic surgery, HHP can serve as a novel, promising methodical approach, by damaging normal and tumor cells without alteration of osteoinductive properties, thus facilitating osteointegration of the devitalized bone segment in cancer patients after reimplantation.

Introduction Besides great advances in hip-alloarthroplasty there are still numerous indications for joint saving procedures as correction osteotomies. Often these procedures include complex 3D rearrangements of the proximal femur, which are for the surgeon technically very demanding because of the (1) complexity of a precise 3D planning of the fragment position and as a second step (2) the exact operative realization of the plan.

The project aim was to minimize these two major problems by using computer assisted techniques for exact intraoperative virtual 3D planning including a detailed biomechanical analysis (as change of head offset, torsion, leg length etc.).

Methods A new key feature is that we extended our former developed geometry based approach using 2 fluoro frames from different angles of the proximal femur to inversely reconstruct the femoral head sphere and additionally mark the head-neck axis and the anatomical femur axis. For navigation a passive infrared based optical system was used with a Polaris-camera, a C-arm calibration kit and PC-based developed software. For in vitro evaluation complex osteotomies were performed on 8 femora under simulated OR conditions.

Results The evaluation showed that the difference between the planning and real surgical outcome for the wedge size was less then 3 and for the femur head center position less then 4.1 mm. No implant penetrated the femur neck isthmus, but in 2 femora the position of the plate resulted in a lateral space of maximal 2 mm between the OT-planes, which was by higher plate tensioning completely compensable. The planning process as well as the operative execution was practicable and time efficient.

Discussion The used method demonstrated from a clinical view point a high accuracy. With the described approach it is for the surgeon directly visible during the planning process what biomechanical impacts his planned procedure will have on the femur head offset, torsion, leg length etc.

So without changing the standard operative procedure the method can be of high clinical importance to improve the accuracy of the planning and the consecutive operative realization for a precise fragment positioning and the plate location without penetrating the isthmus of the femoral neck. So it can potentially help to reduce intraoperative complications and the use of the fluoroscope to minimally 4 frames for the whole procedure.

We have to deal with an increasing number of patients who are suffering from a femoral neck fracture. In Ger-many in 1996 135.000 patients with this kind of fracture were treated. These fractures are usually found in old people and have a high complication rate:

Osteonecrosis of the femoral head: 12–43% (Kyle 1994)

Pseudarthrosis: 16–28% (Rogmark 2002)

The indications for a total hip replacement are:

– age > 65years

– presence of osteoporosis (also under 65)

– daily activity possible (otherwise hemialloarthroplasty)

– comorbidity such as osteoarthritis

We have to consider several aspects:

The mortality rate is lower if we use a hip replacement (THR ~6%, osteosynthesis ~10%) The complication rate is lower if we use hip replacement (THR ~2%, osteosynthesis ~5%) In 30% of cases we have to change from osteosynthesis to a total hip replacement due to secondary complications of osteosynthesis in mobile patients If we look at this data, we must conclude that total hip replacement is the goldstandard in the treatment of femoral neck fractures (with Garden III and IV) in the population older than 65 years. Hemialloarthroplasty is only indicated for patients who are more or less immobilized.

The aim of the study was to evaluate changes in clinical results after extracorporeal shock wave therapy (ESWT) on calcified lesions of the shoulder.

963 patients with calcifying tendinitis were treated with high energy shock waves. The mean energy flux density was 0. 28 mJ/mm2. To evaluate the effect we used the visual analogue scale (VAS) and the Roles-Maudsley-score to analyse the effect on activity of daily living, and pain perception. ESWT was indicated after non operative treatment failed.

At 12 months after ESWT, 73. 6% of patients reported excellent and good results, 26% scored satisfactory and poor, using the Roles-Maudsley-Score. The positive effect of the ESWT on pain perception after 12 months was statistically significant (p< 0. 001). The difference between pain perception before and after ESWT persisted in the follow up interval. No decrease was shown after 2 years. In all cases no severe side effects were observed except small petechial haemorrhages.

High energy shock wave therapy is indicated to treat calcifying tendinitis which is resistant to any other non-operative treatment. The decrease in pain perception persists over a period of more than two years. Absence of side effects and its effectiveness suggest that ESWT is indicated prior to surgical intervention.

The cranial cup is now a standardised implant in acetabular revision surgery. In order to illustrate the positive results of a standardised implant in acetabular revision surgery in comparison to other possibilities of reconstruction, we analysed results of all data in our study group.

Aseptic loosening of implants often causes segmental and cavitary acetabular deficiency. Experiences gained in radical tumour surgery with reconstruction by custommade endoprostheses induced the development of the cranial cup for revision total hip arthroplasty. This new cementless revision cup has an oval shape and a special cranial flap, as well as an intramedullary rod if necessary.

This type of cranial cup has been used since 1993. From 9/97 to 1/99, we implanted 30 cranial cups in revision hip surgery and collected all data of these patients prospectively. Clinical and x-ray follow-up was documented on a regular basis.

Acetabular deficiency occurred twice in type 1, five times in type 2, twenty-two times in type 3 and once in type 4. The AAOS D’Antonio score was used. Cranial cups were implanted without cranial flap in 10 cases, with cranial flap in 20 cases and once using the intramedullary rod additionally. Only 28 patients were included in our last examination because one patient had died and one was bedridden because of a reason other than the hip. The Harris hip score increased from an average of 32 points preoperatively to 63 points postoperatively. Twenty-one patients are satisfied or very satisfied with their surgery. Radiograph examinations showed an average inclination angle of 42.5° in all cranial cups.

Up to now there have been complications in four patients who suffered luxations, but only one required a change of inlay. One intraoperative injury of the urinary bladder had to be revised later. Three implants showed a change of position in x-ray. One was the patient with the urinary bladder injury and possible septic loosening, the second was a patient with extreme osteoporosis, and the third was a patient who did not receive an intramedullary rod for a type 4 lesions. Currently, these three patients do not have any complaints.

We have always achieved primary stability. Morselised bone autografts or bone substitute materials were used to fill remaining defects. An intramedullary rod should be used in pelvis discontinuity and is obligatory to achieve the necessary stability. Developed from the experiences of custom-made tumour endoprostheses, the cranial cup with all possible variations is an appropriate intraoperative variable implant in revision acetabular surgery.

For younger patients many surgeons recommend femoral neck endoprostheses as alternative to stemmed implants in THA. Due to metaphyseal anchorage several advantages are quoted, e.g. preservation of the femoral diaphysis for a revision implant. Determinant factor for long-term implant stability is the load transmission to the bone. Because so far only few information about the load transfer of femoral neck endoprostheses exist, a photoelastic analysis was performed. Aim of the study was the comparison of bony strain pattern before and after implantation of a femoral neck endoprosthesis.

‘Composite-femurs’ (Pacific Research Labs) were used due to of their mechanical characteristics close to human femurs but better reproducibility. Three femurs were coated with photoelastic material. The femurs were loaded prior and post implantation of a femoral neck endoprosthesis type Cigar (ESKA Implants). Test load consisted of the resulting hip joint force and muscle forces (abductors, tractus iliotibialis). Load was applied statically by a universal testing machine and additional weights. Bony strain was measured along the medial, ventral, lateral and dorsal cortex. Statistical analysis of the implant related strain alterations was based on a 99% confidence interval.

The unresected femurs showed an excellent match of bony strain patterns. Implantation of femoral neck endoprostheses caused highly significant strain changes at the trochanteric region. Greatest differences were observed at the lateral cortex. Above the implant’s traction screw former areas of tension changed to compression. Along the medial cortex below the resection plane strain reductions were measured but disappeared at the latest at 40 mm below. No significant changes in strain were detected at the ventral and dorsal cortex.

Implant related bony strain alterations were limited to the trochanteric region of the femur. A marked strain alteration at the lateral trochanteric aspect was measured. Whether this is of clinical importance can not be answered yet.