In this study we try to evaluate the results of intramedullary nailing in the treatment of fractures of diaphysis of humerus. During the time period of 2002 to 2006 46 patients were admitted in our clinic with fracture of the diaphysis of the humerus and 23 patients were treated surgically with intramedullary nailing. 14 patients were directly submitted to intramedullary nailing, 6 patients after unsuccessful conservative treatment and 3 patients due to nonunion after internal fixation. Average age was 51 years old. In 5 patients open reduction was applied while bone grafts were not used in any case. In all cases bone healing was obtained within 6 to 20 weeks (average 11 weeks). Final functional outcome was evaluated with Constant Score and according to it 10 patients demonstrated excellent score (>
75), 7 satisfactory (50–75) and 6 poor(<
50). Postoperative evaluation was based on clinical findings such as pain, range of motion and rehabilitation. As far as complications are concerned 2 cases with severe stiffness of the shoulder were observed and 1 case with malunion. There were no cases with non-union, sterile necrosis or neurological impairment. Intramedullary nailing shows significant advantages such as limited damage to soft tissues, satisfactory retention of osteoporotic fractures, immobility of complex fractures and allows immediate postoperative mobilization.