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Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_6 | Pages 100 - 100
1 Jul 2020
El-Husseiny M Masri BA Duncan C Garbuz D
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Fully constrained liners are used to treat recurrent dislocations or patients at high risk after total hip replacements. However, they can cause significant morbidities including recurrent dislocations, infections, aseptic loosening and fractures. We examine long term results of 111 patients with tripolar constrained components to assess their redislocation and failure rate.

The purpose of this study was to assess survivorship, complications and functional outcomes at a minimum 10 years after the constrained tripolar liners used in our institute.

We retrospectively identified 111 patients who had 113 revision tripolar constrained liners between 1998 and 2008. Eighty-nine were revised due to recurrent dislocations, 11 for pseudotumor with dysfunctional abductors, and 13 for periprosthetic infection with loss of soft tissue stabilizers. All patients had revision hip arthroplasty before the constrained liner was used: 13 after the first revision, 17 after the second, 38 after the third, and 45 had more than 3 revisions. We extracted demographics, implant data, rate of dislocations and incidence of other complications. Kaplan Meier curves were used to assess dislocation and failure for any reason. WOMAC was used to assess quality of life.

At 10 years, the survival free of dislocation was 95.6% (95%CI 90- 98), and at 20 years to 90.6% (95% CI 81- 95.5). Eight patients (7.1%) had dislocations of their constrained liners: 1 patient had simultaneous periprosthetic infection identified at the time of open reduction, and 1 patient sustained stem fracture 3 months prior to the liner dislocation. At 10 years, the survival to any further surgery was 89.4% (95% CI 82–93.8), and at 20 years, this was 82.5 (95% CI 71.9–89.3). Five patients (4.4%) had deep infection: 4 of these had excision arthroplasty due to failure to control infection, while 1 patient was treated successfully with debridement, exchange of mobile components and intravenous antibiotics. Two patients (1.8%) had dissociated rings that required change of liner, ring and head. Two patients (1.8%) had periprosthetic femoral fractures that were treated by revision stems and exchange of constrained liners. The mean WOMAC functional and pain scores were 66.2 and 75.9 of 100, respectively.

Constrained tripolar liners in our institute provided favourable results in the long term for recurrent dislocation hip arthroplasty with dysfunctional hip stabilizers. Infection in these patients can prove to be difficult to treat due to their poor soft tissue conditions from repeated surgeries. Comparing long terms results from other types of constrained liners is essential to evaluate these salvage liners.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_6 | Pages 99 - 99
1 Jul 2020
El-Husseiny M Masri BA Duncan CP Garbuz D
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High complication rates and poor outcomes have been widely reported in patients undergoing revision of large head metal-on-metal arthroplasty. A previous study from our centre showed high rates of dislocation, nerve injury, early cup loosening and pseudotumor recurrence. After noting these issues, we implemented the following changes in surgical protocol in all large head MOM revisions: One: Use of highly porous shells in all cases. Two: Use of largest femoral head possible. Three: Low threshold for use of dual mobility and constrained liners when abductors affected or absent posterior capsule. Four: Use of ceramic head with titanium sleeve in all cases. Five: Partial resection of pseudotumor adjacent to sciatic and femoral nerves.

The purpose of the present study is to compare the new surgical protocol above to our previously reported early complications in this group of patients

We specifically looked at (1) complications including reoperations, (2) radiologic outcomes, and (3) functional outcomes. Complication rates after (Group 1), and before (Group 2) modified surgical protocol were compared using Chi-square test, assuming statistical significance p < 0 .05.

Major complications occurred in 4 (8.3%) of 48 patients who had modified surgical technique, compared to 12 (38%) of 32 revisions prior to modification (p < 0 .05). Two hips of 48 (4.17%) endured dislocations in Group 1, compared to 9 of 32 (28%) in Group 2 (p < 0 .05). Four patients of 48 had repeat revision in Group 1: 2 for recurrence of pseudotumor, 1 for dislocation, and 1 for infection, compared to 6 patients who had 7 repeat revisions of 32 patients in Group 2: 3 for acetabular loosening, 3 for dislocation, and 1 for recurrence of pseudotumor (p=0.1). None of 48 revisions in Group 1 had acetabular loosening, compared to 4 of 32 in Group 2 (p=0.02). Two patients had nerve injury in Group 2, compared to none in Group 1 (p=0.16). The mean WOMAC pain score was 87.1 of 100 and the function score was 88.4 of 100 in Group 1, compared to a mean WOMAC pain score of 78 of 100 (p=0.6) and a function score of 83 of 100 in Group 2 (p=0.8).

Modification of the surgical techniques described in the introduction has resulted in a significant decrease in complications in revision of large head MOM total hips. We continue to use this protocol and recommend it for these difficult cases.


The Bone & Joint Journal
Vol. 101-B, Issue 6_Supple_B | Pages 123 - 126
1 Jun 2019
El-Husseiny M Masri B Duncan C Garbuz DS

Aims

We investigated the long-term performance of the Tripolar Trident acetabular component used for recurrent dislocation in revision total hip arthroplasty. We assessed: 1) rate of re-dislocation; 2) incidence of complications requiring re-operation; and 3) Western Ontario and McMaster Universities osteoarthritis index (WOMAC) pain and functional scores.

Patients and Methods

We retrospectively identified 111 patients who had 113 revision tripolar constrained liners between 1994 and 2008. All patients had undergone revision hip arthroplasty before the constrained liner was used: 13 after the first revision, 17 after the second, 38 after the third, and 45 after more than three revisions. A total of 75 hips (73 patients) were treated with Tripolar liners due to recurrent instability with abductor deficiency, In addition, six patients had associated cerebral palsy, four had poliomyelitis, two had multiple sclerosis, two had spina bifida, two had spondyloepiphyseal dysplasia, one had previous reversal of an arthrodesis, and 21 had proximal femoral replacements. The mean age of patients at time of Tripolar insertions was 72 years (53 to 89); there were 69 female patients (two bilateral) and 42 male patients. All patients were followed up for a mean of 15 years (10 to 24). Overall, 55 patients (57 hips) died between April 2011 and February 2018, at a mean of 167 months (122 to 217) following their tripolar liner implantation. We extracted demographics, implant data, rate of dislocations, and incidence of other complications.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_13 | Pages 72 - 72
1 Oct 2018
El-Husseiny M Masri BA Duncan CP Garbuz DS
Full Access

Background

Fully constrained liners are used to treat recurrent dislocations or patients at high risk after total hip replacements. However, they can cause significant morbidities including recurrent dislocations, infections, aseptic loosening and fractures. We examine long term results of 111 patients with tripolar constrained components to assess their redislocation and failure rate.

Questions/purposes

The purpose of this study was to assess survivorship, complications and functional outcomes at a minimum 10 years after the constrained tripolar liners used in our institute.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_13 | Pages 73 - 73
1 Oct 2018
El-Husseiny M Masri BA Duncan CP Garbuz DS
Full Access

Background

High complication rates and poor outcomes have been widely reported in patients undergoing revision of large head metal-on-metal arthroplasty. A previous study from our center showed high rates of dislocation, nerve injury, early cup loosening and pseudotumor recurrence. After noting these issues, we implemented the following changes in surgical protocol in all large head MOM revisions: 1. Use of highly porous shells in all cases 2. Use of largest femoral head possible 3. Low threshold for use of dual mobility and constrained liners when abductors affected or absent posterior capsule 4. Use of ceramic head with titanium sleeve in all cases 5. Partial resection of pseudotumor adjacent to sciatic and femoral nerves.

Questions/purposes

The purpose of the present study is to compare the new surgical protocol above to our previously reported early complications in this group of patients

We specifically looked at (1) complications including reoperations; (2) radiologic outcomes; and (3) functional outcomes. Complication rates after (Group 1), and before (Group 2) modified surgical protocol were compared using Chi-square test, assuming statistical significance p<0.05.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_19 | Pages 10 - 10
1 Apr 2013
Elnikety S El-Husseiny M Kamal T Gregoras M Talawadekar G Jeer P
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Introduction

The transtibial approach is widely used for femoral tunnel positioning in ACL reconstruction. Controversy exists over the superiority of this approach over others. Few studies reflected on the reproducibility rates of the femoral tunnel position in relation to the approach used.

Methods

We reviewed AP and Lat X-ray radiographs post isolated ACL reconstruction for 180 patients for femoral tunnel position, tibial tunnel position and graft inclination angle. All patients had their operations performed by one surgeon in one hospital between March 2006 and Sep 2010. All operations were performed using one standard technique using transtibial approach for femoral tunnel positioning. Two orthopaedic fellows, with similar experiences, reviewed blinded radiographs. A second reading was done 8 weeks later. Pearson inter-observer and intra-observer correlation analyses were done using SPSS. Mean age was 29 years (range 16–54).


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XLII | Pages 3 - 3
1 Sep 2012
Elnikety S El-Husseiny M Kamal T Gregoras M Talawadekar G Jeer PJS
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The transtibial approach is widely used for femoral tunnel positioning in ACL reconstruction. Controversy exists over the superiority of this approach over others. Few studies reflected on the reproducibility rates of the femoral tunnel position in relation to the approach used.

We reviewed AP and Lat X-ray radiographs post isolated ACL reconstruction for 180 patients for femoral tunnel position, tibial tunnel position and graft inclination angle. All patients had their operations performed by one surgeon in one hospital between March 2006 and Sep 2010. All operations were performed using one standard technique using transtibial approach for femoral tunnel positioning.

Two orthopaedic fellows, with similar experiences, reviewed blinded radiographs. A second reading was done 8 weeks later. Pearson inter-observer, intra-observer correlation and Bland-Altman agreements plots statistical analyses were done.

Mean age was 29 years (range 16–54), Pearson intra-observer correlation shows substantial to perfect agreement while Pearson's inter-observer correlation shows moderate to substantial agreement.

Previous literature proved that optimal femoral tunnel position for the best clinical and biomechanical outcome is for the centre of the tunnel to be at 43% from the lateral end of the width of the femoral condyles on the AP view and at 86% from the anterior end of the Blumensaat's line on the lateral view. In our study 85% of the femoral tunnels were within +/− 5% of the optimal tunnel position on the AP views, and more than 70% of the femoral tunnels were within +/−5% of the optimal tunnel position on the Lateral view. Interobserver and intraobserver corelations show moderate to substantial agreement, Bland-Altman agreement plots show substantial agreements for interobserver and intraobserver measurements. These results were found to be statistically significant at 0.01

Based on our results we conclude that using one standardised transtibial technique for ACL reconstruction can result in high reproducibility rates of optimal femoral tunnel position. Further studies are needed to validate our results and to study the reproducibility rates for different approaches and techniques.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 135 - 135
1 Sep 2012
El-Husseiny M Pendegrass C Haddad F Blunn G
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Introduction

Intraosseous transcutaneous amputation prostheses (ITAP) provide an alternative means of attaching artificial limbs for amputees. Conventional stump-socket devices are associated with soft tissue complications including; pressure sores and tissue necrosis. ITAP resolves these problems by attaching the exo-prosthesis transcutaneously to the skeleton. The aim of this study is to increase the attachment of dermal fibroblasts to titanium alloy in vitro. Fibronectin (Fn) and laminin 332 (Ln) enhance early cell growth and adhesion. We hypothesize that silanized dual coatings of fibronectin and laminin (SiFnLn) will be more durable when compared with adsorbed dual coating (AdFnLn), and will enhance early fibroblast growth and adhesion compared to single coatings.

Methods

The kinetics of dual single and dual protein coating attachment onto titanium alloy was quantified on silanized 10mm diameter discs using radiolabelled Fn (125I-Fn) and Ln (125I-Ln). Sixty discs were polished, sterilized and silanized. Coating durability was assessed when soaked in fetal calf serum (FCS) for 0, 1, 24, 48 and 72hrs. Data was compared to un-silanized Ti discs with the same coatings. Five thousand human dermal fibroblasts were seeded on discs (n = 6) of Ti polished alone (Pol), Ti with adsorbed fibronectin (AdFn), Ti with adsorbed laminin (AdLn), Ti adsorbed dual coating (AdFnLn), Ti silanized (Si), Ti silanized with fibronectin (SiFn), Ti silanized with laminin (SiLn), Ti silanized with a dual coating (SiFnLn) for 24hrs. In order to measure cell adhesion fibroblasts were fixed, vinculin stained using mouse vinculin antibody and alexa fluor. Axiovision Image Analysis software was used to measure cell area, vinculin focal adhesion markers per cell and per unit cell area. Data was analysed in SPSS and significance was assumed at the 0.05 level.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 136 - 136
1 Sep 2012
El-Husseiny M Pendegrass C Elnikety S Haddad F Blunn G
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Introduction

Following amputation, residual stumps used to attach the external prostheses can be associated with sores, infection and skin necrosis. These problems could be overcome by off loading the soft tissues. Intraosseous transcutaneous amputation prostheses (ITAP) attach external implants directly to residual bone reducing these complications. However, a tight seal at the skin implant interface is crucial in preventing epithelial down-growth and infection. Fibronectin (Fn) and laminin 332 (Ln), enhance early cell growth and adhesion of keratinocytes. Silanization to titanium alloy (Ti) allows these proteins to bond to the metal directly. We hypothesize that silanized dual coatings of fibronectin and laminin (SiFnLn) will be more durable than absorbed proteins and that keratinocyte adhesion will be increased compared with Ti controls and single silanized proteins.

Methods

10 mm diameter Ti alloy discs were polished, sterilized and silanized. The kinetics of silanized single and dual protein coating attachment onto titanium alloy was quantified using radio-labelled Fn(125I-Fn) and Ln(125I-Ln). Coating durability was assessed when soaked in fetal calf serum (FCS) for 0, 1, 24, 48, 72hrs. Data was compared to un-silanized Ti discs with the same amount of adsorbed proteins. In order to study cell attachment 20 × 103 keratinocytes were seeded on the discs (n = 6): silanized (Si), silanized fibronectin (SiFn), silanized laminin (SiLn), silanized dual coating (SiFnLn) for 1, 4 and 24hrs. Adhesion of cells was assessed using mouse vinculin antibody for 2hrs and alexafluor for 1hr which stains focal adhesions responsible for attaching cells to surfaces. Axiovision Image Analysis software was used to measure cell area, vinculin markers per cell unit and per unit cell area on 15 cells per disc. Data was analysed in SPSS and significance was assumed at the 0.05 level.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 439 - 439
1 Sep 2012
El-Husseiny M Patel S Hossain F Haddad F
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AIM

Failure of a primary anterior cruciate ligament (ACL) reconstruction is associated with poor functional outcomes even after revision surgery. The aim of this study is to identify early predictors for failure, so that it may aid in recognition of at-risk patients.

METHOD

An observational study was conducted of 623 patients undergoing primary ACL reconstruction by a single surgeon over a 72 month period. Patient and procedure related parameters including age, gender, BMI, time to surgery, graft size, fixation methods, meniscal and chondral injuries, meniscal surgery, radiological parameters and post-operative IKDC scores. Logistic regression modeling was employed to identify those factors which were statistically significant for failure.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 135 - 135
1 Sep 2012
Elnikety S El-Husseiny M Kamal T Talawadekar G Triggs N Richards H Smith A
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Introduction

“No routine post-operative follow up appointments” policy has been implemented in NHS hospitals in different specialties for uncomplicated surgical procedures. In trauma and orthopaedics few studies to date reviewed this practice and reflected on the patients' opinions.

Methods

A total of 121 patients were recruited over 2 years, each patient had post operative follow up by the hand therapist for 3 months. 50 patients post Trapeziectomy and 71 patients post single digit Dupuytren's fasciectomy were prospectively surveyed for their opinion on their post operative care and whether they would have liked to be reviewed by the surgeon in a routine post operative follow up appointment or not. All operations were done by one surgeon in one hospital. All patients were reviewed by a hand therapist within 2 weeks post operatively and treatment protocols were followed with all the patients. During their final appointment with the hand therapist all patients completed a questionnaire.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XVI | Pages 7 - 7
1 Apr 2012
Elnikety S Singh BI Kamal T El-Husseiny M Brooks CH Wetherell RG
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In this study we reviewed all Total Elbow Replacements (TER) done in our hospital over eight years period (1997 – 2005), 21 patients (16 females, 5 males) were available for follow up and four were lost (two died and two moved out of the region) with average age of 65 years (range 44 – 77), all procedures were done by two upper limb surgeons (CHB & RGW). 16 patients (14 females, 2 males) had the procedure for Rheumatoid Arthritis and 5 patients (3 males, 2 females) undergone the procedure for post-traumatic arthritis.

The average follow up was 61 months (range 12 – 120 months), the Mayo Clinic performance index, the DASH scores and activities of daily living (adopted from Secec Elbow Score) assessment tools were used. In addition, all patients were assessed for loosening using standard AP and lateral radiographs. Sixteen patients had Souter-Starthclyde prosthesis whilst three had Kudo and two had Conrad-Moorey prosthesis.

All procedures were done through dorsal approach and all were cemented, the ulnar nerve was not transposed in any of the cases. The average elbow extension lag was 27 degrees (range 15 – 35) with flexion up to 130 degrees (range 110 – 140). Supination was 65 degrees (range 15 – 90) and pronation was 77 (range 55 – 90). The average DASH score was 51.3 (range 19 – 95), the Mayo elbow score was 82 (range 55 – 100) and the average Activities of daily living Secec Score was 17 (range 10 – 20).

There were four complications, three ulnar nerve paresis which recovered and one wound complication which needed a flap cover. Two needed revision surgery, one for a periprosthetic fracture and one for loosening. Two patients showed radiological signs of loosening but were asymptomatic. The survival rate with revision as the end point is 95% for aseptic loosening and 90% for any other reason.

Our study proves TER has good medium term results with good functional outcome and high patient satisfaction rate.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 4 | Pages 564 - 569
1 Apr 2012
Pendegrass CJ El-Husseiny M Blunn GW

The success of long-term transcutaneous implants depends on dermal attachment to prevent downgrowth of the epithelium and infection. Hydroxyapatite (HA) coatings and fibronectin (Fn) have independently been shown to regulate fibroblast activity and improve attachment. In an attempt to enhance this phenomenon we adsorbed Fn onto HA-coated substrates. Our study was designed to test the hypothesis that adsorption of Fn onto HA produces a surface that will increase the attachment of dermal fibroblasts better than HA alone or titanium alloy controls.

Iodinated Fn was used to investigate the durability of the protein coating and a bioassay using human dermal fibroblasts was performed to assess the effects of the coating on cell attachment. Cell attachment data were compared with those for HA alone and titanium alloy controls at one, four and 24 hours. Protein attachment peaked within one hour of incubation and the maximum binding efficiency was achieved with an initial droplet of 1000 ng. We showed that after 24 hours one-fifth of the initial Fn coating remained on the substrates, and this resulted in a significant, three-, four-, and sevenfold increase in dermal fibroblast attachment strength compared to uncoated controls at one, four and 24 hours, respectively.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 175 - 175
1 May 2011
Patel S Hossain F El-Husseiny M Haddad F
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Introduction: Rupture of the anterior cruciate ligament (ACL) is a serious injury associated with symptomatic instability of the knee. There is an increasing trend for confirmation of diagnosis with magnetic resonance imaging (MRI) before proceeding to reconstruction. The overall sensitivity and specificity of diagnosis using this modality is more than 95%. It is however observer-dependent. We have developed a simple 4 point recognition card to increase the pick-up rate of this injury for professionals without specific radiological training such as orthopaedic trainees. The aim of this study was to determine how much improvement could be achieved using this card and whether any change was sustained.

Methods: 20 participants (orthopaedic trainees surgeons and medical students) were shown 20 MRI scans of the knee (10 with complete ACL ruptures and 10 with normal ACLs) and asked which scans were demonstrative of ACL pathology. Each participant was then randomly allocated to either having verbal teaching in the standard fashion about detection of ACL injuries [Group 1] or given written cards detailing a 4 point recognition plan for recognising ACL injuries on MRI [Group 2]. A repeat test of MRI scans was performed on each participant immediately after the teaching session and at 3 weeks.

Results: The mean time taken to teach Group A was 14 mins and Group B was 11 mins (p < 0.05). The mean number of correct diagnoses was 2.7/10 in Group A and 3.1/10 in Group B pre-intervention (p > 0.05). Immediately following intervention, there were 6.1 correct diagnoses in Group A and 8.2 in Group B (p < 0.05). At 3 weeks, there were 3.4 correct diagnoses in Group A and 7.9 in Group B (p < 0.05). The difference in number of correct diagnoses at 3 weeks compared to immediately following intervention was significant in Group A (p < 0.05), but not in Group B (p > 0.05).

Conclusions: The results support the use of the 4 point recognition card as to tool for increasing the pick-up of ACL injuries on MRI. It offers advantages over standard teaching Methods: since it takes less time to teach and the necessary information is retained to a greater degree than with traditional teaching methods.


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 2 | Pages 151 - 157
1 Feb 2011
El-Husseiny M Patel S MacFarlane RJ Haddad FS

Bacterial infection in orthopaedic surgery can be devastating, and is associated with significant morbidity and poor functional outcomes, which may be improved if high concentrations of antibiotics can be delivered locally over a prolonged period of time. The two most widely used methods of doing this involve antibiotic-loaded polymethylmethacrylate or collagen fleece. The former is not biodegradable and is a surface upon which secondary bacterial infection may occur. Consequently, it has to be removed once treatment has finished. The latter has been used successfully as an adjunct to systemic antibiotics, but cannot effect a sustained release that would allow it to be used on its own, thereby avoiding systemic toxicity.

This review explores the newer biodegradable carrier systems which are currently in the experimental phase of development and which may prove to be more effective in the treatment of osteomyelitis.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 503 - 503
1 Oct 2010
El-Husseiny M Haddad F Potty A Rayan F
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Background: Medial plica syndrome is the most common symptomatic plica. The size and shape of the plica have an important impact on impingement on the femoral condyle and hence, symptoms. The validity of the classification systems of such injuries is essential for prospective studies. The study was designed to assess the reproducibility and reliability of Iino and Jee classification systems of medial plica syndrome. The agreement among multiple surgeons for medial plica syndrome has not been established before.

Methods: We validated both classification systems independently from the original authors at our institution. Arthroscopic videos from 30 patients were reviewed by 6 consultant surgeons, 6 registrars and 6 house officers. Intra- and inter-observer reliability and reproducibility were assessed. Each observer scored the videos on two separate occasions and classified the medial plica according to its type (A, B, C and D) for Iino classification and (1, 2, 3 and 4) for Jee classification system.

Results: The results were subjected to weighted kappa analysis. Intra-observer agreements were 0.76 for consultants, 0.64 for registrars and 0.60 for house officers for Iino classification system. They were 0.81 for consultants, 0.75 for registrars and 0.71 for house officers for Jee classification system. Total unanimity (18 observers assigned same grade for medial plica) was achieved in 23% (7 of 30) with Iino system and 40%(12 of 30) for Jee system. Inter-observer agreement was 0.63 for the first reading and 0.68 for the second reading for Iino system. They were 0.72 for the first reading and 0.80 for the second reading for Jee system. Validity analysis showed a kappa value of 0.78 (substantial agreement).

Conclusions: Jee classification system showed a better inter and intra-observer agreement compared to Iino’s system. Consultants had a better intra-observer agreement compared to their registrars. We have shown that substantial agreement can be found between individuals with no specialist training. Such reliability is crucial for multi-centre clinical research studies involving arthroscopic knee surgery. Jee’s classification system did not consider femoral condyle impingment which has an important effect on symptoms. Both systems should be used in prospective studies to evaluate the state of the medial plica.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 281 - 281
1 May 2010
El-Husseiny M Coleman N
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The study was designed to assess the reproducibility and reliability of Mirels scoring system and the conventional scoring system for impending pathological fractures. The results of both classification systems influence the choice of therapeutic procedures offered to these patients.

Blinded plain antero-posterior radiographs from forty-seven patients with bone metastases were scored by eight independent observers (four orthopaedic surgeons and four radiologists with varying clinical experience). Each observer scored the radiographs as per the Mirels and the conventional systems. After twelve weeks, the radiographs were scored again by the same observers. Inter– and intra-observer agreement was assessed based on the weighted kappa coefficient values for both systems.

For intra-observer reproducibility, kappa values for the conventional system had a mean of 0.495 (SD 0.12) showing a moderate agreement, while Mirels scoring system had a mean of 0.386 (SD 0.143) showing a fair agreement. For inter-observer reliability, kappa values for the conventional scoring system were 0.322 for the first test and 0.47 for the second test giving fair and moderate agreements respectively. For Mirels’ scoring system, kappa coefficient for inter-observer reliability was 0.183 for the first test and 0.218 for the second giving poor and fair agreements respectively.

The conventional scoring system showed a better inter and intra-observer agreement compared to Mirels’ scoring system. Consultants had a better intra-observer agreement compared to their registrars. We also found that radiologists, in our study, had better intra-observer agreement compared to orthopaedic surgeons. Radiographs should be scored cautiously by experienced doctors in a multi-disciplinary setting to achieve the best decision of whether to proceed with a prophylactic surgery or not.