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The Bone & Joint Journal
Vol. 99-B, Issue 5 | Pages 623 - 631
1 May 2017
Blaney J Harty H Doran E O’Brien S Hill J Dobie I Beverland D

Aims

Our aim was to examine the clinical and radiographic outcomes in 257 consecutive Oxford unicompartmental knee arthroplasties (OUKAs) (238 patients), five years post-operatively.

Patients and Methods

A retrospective evaluation was undertaken of patients treated between April 2008 and October 2010 in a regional centre by two non-designing surgeons with no previous experience of UKAs. The Oxford Knee Scores (OKSs) were recorded and fluoroscopically aligned radiographs were assessed post-operatively at one and five years.


The Bone & Joint Journal
Vol. 98-B, Issue 3 | Pages 341 - 348
1 Mar 2016
Ogonda L Hill J Doran E Dennison J Stevenson M Beverland D

Aims

The aim of this study was to present data on 11 459 patients who underwent total hip (THA), total knee (TKA) or unicompartmental knee arthroplasty (UKA) between November 2002 and April 2014 with aspirin as the primary agent for pharmacological thromboprophylaxis.

Patients and Methods

We analysed the incidence of deep vein thrombosis (DVT) and pulmonary embolism (PE) then compared the 90-day all-cause mortality with the corresponding data in the National Joint Registry for England and Wales (NJR).


The Bone & Joint Journal
Vol. 96-B, Issue 2 | Pages 201 - 209
1 Feb 2014
Napier RJ Bennett D McConway J Wilson R Sykes AM Doran E O’Brien S Beverland DE

In an initial randomised controlled trial (RCT) we segregated 180 patients to one of two knee positions following total knee replacement (TKR): six hours of knee flexion using either a jig or knee extension. Outcome measures included post-operative blood loss, fall in haemoglobin, blood transfusion requirements, knee range of movement, limb swelling and functional scores. A second RCT consisted of 420 TKR patients randomised to one of three post-operative knee positions: flexion for three or six hours post-operatively, or knee extension.

Positioning of the knee in flexion for six hours immediately after surgery significantly reduced blood loss (p = 0.002). There were no significant differences in post-operative range of movement, swelling, pain or outcome scores between the various knee positions in either study. Post-operative knee flexion may offer a simple and cost-effective way to reduce blood loss and transfusion requirements following TKR.

We also report a cautionary note regarding the potential risks of prolonged knee flexion for more than six hours observed during clinical practice in the intervening period between the two trials, with 14 of 289 patients (4.7%) reporting lower limb sensory neuropathy at their three-month review.

Cite this article: Bone Joint J 2014;96-B:201–9.


The Bone & Joint Journal
Vol. 95-B, Issue 2 | Pages 181 - 187
1 Feb 2013
Liddle AD Pandit H O’Brien S Doran E Penny ID Hooper GJ Burn PJ Dodd CAF Beverland DE Maxwell AR Murray DW

The Cementless Oxford Unicompartmental Knee Replacement (OUKR) was developed to address problems related to cementation, and has been demonstrated in a randomised study to have similar clinical outcomes with fewer radiolucencies than observed with the cemented device. However, before its widespread use it is necessary to clarify contraindications and assess the complications. This requires a larger study than any previously published.

We present a prospective multicentre series of 1000 cementless OUKRs in 881 patients at a minimum follow-up of one year. All patients had radiological assessment aligned to the bone–implant interfaces and clinical scores. Analysis was performed at a mean of 38.2 months (19 to 88) following surgery. A total of 17 patients died (comprising 19 knees (1.9%)), none as a result of surgery; there were no tibial or femoral loosenings. A total of 19 knees (1.9%) had significant implant-related complications or required revision. Implant survival at six years was 97.2%, and there was a partial radiolucency at the bone–implant interface in 72 knees (8.9%), with no complete radiolucencies. There was no significant increase in complication rate compared with cemented fixation (p = 0.87), and no specific contraindications to cementless fixation were identified.

Cementless OUKR appears to be safe and reproducible in patients with end-stage anteromedial osteoarthritis of the knee, with radiological evidence of improved fixation compared with previous reports using cemented fixation.

Cite this article: Bone Joint J 2013;95-B:181–7.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IX | Pages 9 - 9
1 Mar 2012
Pagoti R O'Brien S Doran E Beverland D
Full Access

A prospective study of 276 TKA's performed in patients with valgus knee deformity ≥ 10° using a Modified Surgical Technique.

MATERIALS AND METHODS

Bone cuts were used to balance the valgus knee and soft tissue release was confined to the postero-lateral capsule in severe deformity. The aim was to restore a “functional mechanical axis” as opposed to a “neutral” mechanical axis. All surgeries were performed between Jan2003 and Apr2007, under the care of a single surgeon using an LCS rotating platform. All patients had full length radiographs and outcome scores collected prospectively.

RESULTS

The mean coronal alignment of the lower limb was corrected from 15.9°(10-45°) to 3.8°. 94% patients had their coronal alignment restored to = 7°. Sixteen knees with postoperative valgus ≥8° were analysed as a separate group. The mechanical axis deviation was corrected from 52.3mm to 8.8mm. The distal femoral cut was made at 5° valgus in 131 knees(47.5%), 6° in 111 knees(40.2%) and 7° in 24 knees(8.7%).78 knees(28%) were balanced only with bone cuts. 198 knees(72%) had release of posterolateral capsule. 16 knees(5.8%) also had release of IT band. Lateral patellar release was performed in 39 knees (14%) and 23 knees had patella contouring. 93%knees had central patello-femoral alignment postoperatively. One spinout was managed by closed reduction and a second patient had revision of tibial tray for collapse. Patellar subluxation occurred in two patients. The oxford knee score and the American Knee Society clinical score improved from 48.5 to 26 and 21.04 to 86.03 respectively.


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 12 | Pages 1581 - 1585
1 Dec 2007
McConway J O’Brien S Doran E Archbold P Beverland D

Between April 1992 and July 2005, 310 posterior lip augmentation devices were used for the treatment of recurrent dislocation of the hip in 307 patients who had received primary total hip replacements (THRs) using Charnley/Charnley Elite components with a cemented acetabulum. The mean number of dislocations before stabilisation with the device was five (1 to 16) with a mean time to this intervention from the first dislocation of 3.8 years (0 days to 22.5 years). The mean age of the patients at this reconstruction was 75.4 years (39 to 96).

A retrospective clinical and radiological review was carried out at a mean follow-up of six years and nine months (4.4 months to 13 years and 7 months). Of the 307 patients, 53 had died at the time of the latest review, with a functioning THR and with the posterior lip augmentation device in situ. There were four revisions (1.3%), one for pain, two for deep infection and one for loosening of the acetabular component. Radiolucent lines around the acetabular component increased in only six cases after insertion of the device which was successful in eliminating instability in 302 patients, with only five further dislocations (1.6%) occurring after its insertion.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_II | Pages 123 - 123
1 Feb 2004
Sloan S Thompson N Doran E Brown J
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We report the result of 46 patients (30 female, 16 male) with periprosthetic femoral fractures who underwent insertion of the Kent Hip Prosthesis. Average age was 73 years (range 43–96years) and follow-up ranged from one to seven years (average, 4 years). The primary implants involved were as follows: Charnley (26), Austin Moore (6), Howse (5), Custom (4), Exeter (1), DHS (1), Thompson (1) and Richards (1). Average time to fracture from insertion of the primary implant ranged from 3 weeks to 20 years (average, 8 years). Forty cases were post-primary implant fractures (38 traumatic, 2 atraumatic) and 6 occurred intraoperatively. Using the Johanssen classification there were 12 type I, 30 type II and two type III fractures. Of the 46 cases, prior to fracture, 42 were living in their own home, 24 were mobile unaided and 20 had thigh and/or groin pain. Thirty-two had a loose stem and/or cup assessed at the time of surgery. Operating time was on average 143 mins (65–235mins). At latest follow-up, 43 were living in their own home, 5 were walking unaided and 10 had ongoing pain. In 34 cases complete union was achieved. There were no cases on non-union. Three patients required revision surgery for broken stems. Three patients sustained wound infections and there were six posterior dislocations. All of the complications were treated satisfactorily. We conclude that the Kent Hip Prosthesis is a useful option in the management of periprosthetic femoral fractures.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 71 - 71
1 Jan 2004
Bailie G Doran E Nixon J
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Introduction: The Spotorno cementless femoral stem relies on proximal press-fit at time of surgery and subsequent osseointegration for long-term fixation. The aim of the study is to assess the long-term survivorship and clinical outcome of the Spotorno stem used in primary hip replacement surgery in younger patients.

Materials and Methods: 74 patients were identified who had undergone 90 THRs using the Spotorno CLS stem between January 1987 and May 1992. There was variation in the acetabular components used. 5 patients (6 hips) were lost to follow-up, leaving a study group of 84 hips. The patients were assessed using the Harris Hip Score and the Oxford Hip Score.

Results: Mean age at operation was 40.1years (range 23–65years). Commonest diagnoses were primary osteoarthritis, developmental dysplasia of the hip and rheumatoid arthritis. Mean duration of follow-up was 12.25 years (range 8½ – 15yrs 3months). At most recent follow-up, the mean Oxford Hip Score was 23.8 and mean Harris Hip Score was 81. Taking revision for any cause as an end point, 19 hips from the initial group of 84 had undergone some form of revision surgery at most recent review. 15 of the 19 hips that failed had aseptic loosening of the acetabular component, which was the Mecring component, and underwent revision of acetabulum only. Four stems were revised, 2 for loosening and 2 for infection. 80 out of 84 of stems originally implanted remained intact at most recent review, which represents a stem survivorship of 95.2% at mean 12.25yrs follow-up when used in young patients.

Conclusion: Our findings indicate excellent long-term survival of this titanium alloy stem when used in patients under 65years. We attribute this to stem design and the principle of proximal press-fit fixation. Careful consideration must be given to acetabular component selection in cementless total hip arthroplasty.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_I | Pages 8 - 8
1 Mar 2002
Mohan B Nixon PJ Doran E Kumar A
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In Musgrave Park Hospital, Belfast, younger patients requiring THR were treated by custom-made titanium alloy femoral prosthesis. The identifit hips, which were used initially, were intraoperatively customised by preparing a silicon mould of the endosteal cavity and immediate computer assisted fabrication. The Xpress hips used measurements from preoperative marker x-rays allowing creation of templates and subsequent computer analysis to mill a stem prior to surgery.

7 identifit and 51 Xpress primary uncemented custom THRs were inserted in 50 patients between May 92 and June 96. The average age for the indentifit cases was 47 years (range 24–72) and the Xpress cases 39 years (range 23–51). The Xpress cases were followed up to an average of 47 months (range 12–74 months) and identifit cases to an average of 59 months (range 14–77 months). The indications for arthroplasty were osteoarthrosis in 15 hips, CDH in 14, dysplasia in 11, AVN in 4, rheumatoid arthritis in 3 and other diagnosis in 11. Clinical assessments were made using the Oxford score and the Modified Harris Hip score. The postoperative radiographs were evaluated for subsidence of the prosthesis; and adaptive osseous changes like osteolysis, hypertrophic cortical remodelling, sclerotic radiolucent line formation around the prosthesis and formation of a bone pedestal below the tip of the prosthesis.

The average post-op Oxford hip score for those patients not revised was 32.5 /60 (range 12–51).

16 of the 51 Xpress hips underwent revision and 2 were awaiting revision, which is a failure rate of 35.3%. Of the identifit hips 1 out of the 7 was revised (14.3%). Overall 32.8% was the rate of failure. The average duration from primary operation to revision was 47 months for Xpress hips and 90 months for the identifit hips. Of the Xpress hips, revision was done for acetabular component in 1, femoral component in 4, both components in 1, acetabular liner + femoral head in 1 and acetabular liner + femoral component in 9. The 1 revision in the identifit hip was for recurrent dislocation.

The reasons for revision in the Xpress hips were dislocation in 2 cases, loose femoral component in 13 cases and infection in 1.

Average subsidence of the femoral component was 6mm (range 0–25.9) and this did not have significant correlation with predicting outcome. Pedestal formation (intramedullary formation of bone beneath the tip of the femoral stem) was seen in 87%, sclerotic rediolucent lines were seen in 64%, osteolysis was found in 31% and hypertrophic cortical remodelling was seen in 31%. These also did not reach significance in predicting outcome.

Thus even though the idea of an uncemented custom THR is attractive, especially in the younger age group, the failure rate was found to be unacceptably high. On the basis of these data we have discontinued the use of this custom made non-porous uncemented femoral prosthesis.